Study Results
Results pending
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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Recruitment Status
COMPLETED
Clinical Phase
PHASE3
Total Enrollment
60 participants
Study Classification
INTERVENTIONAL
Study Start Date
2022-04-11
Study Completion Date
2025-06-10
Brief Summary
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Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of metformin treatment at a dose of 1700 mg / day in adults with Huntington's disease.
The study consists of a screening period (2 to 4 weeks), followed by a 52-week double-blind treatment period and a follow-up visit (one month after the end of treatment).
The study consists of a screening period (2 to 4 weeks), followed by a 52-week double-blind treatment period and a follow-up visit (one month after the end of treatment).
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Detailed Description
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Multicenter, randomized, double-blind, placebo-controlled, parallel group study to assess the efficacy and safety of treatment with metformin at a dose of 1700 mg / day in adults with HD.
A total recruitment of 60 patients is expected, which will be randomized in a 1: 1 ratio. 30 patients will receive metformin 1700 g / day, or placebo, for 52 weeks.
Patients will begin taking low doses of metformin, to facilitate tolerance and decrease intestinal discomfort. Half the daily dose (425 mg twice daily) will be administered over four weeks, along with the main meals. Patients who tolerate this dose well will continue with treatment by taking 850mg twice daily. Patients who don´t tolerate the initial dose (425 mg twice daily) will be withdrawn from the study.
A total recruitment of 60 patients is expected, which will be randomized in a 1: 1 ratio. 30 patients will receive metformin 1700 g / day, or placebo, for 52 weeks.
Patients will begin taking low doses of metformin, to facilitate tolerance and decrease intestinal discomfort. Half the daily dose (425 mg twice daily) will be administered over four weeks, along with the main meals. Patients who tolerate this dose well will continue with treatment by taking 850mg twice daily. Patients who don´t tolerate the initial dose (425 mg twice daily) will be withdrawn from the study.
Conditions
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Huntington Disease
Study Design
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Allocation Method
RANDOMIZED
Intervention Model
PARALLEL
Primary Study Purpose
TREATMENT
Blinding Strategy
DOUBLE
Participants
Investigators
Double-blind
Study Groups
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Metformin
Therapeutic group: Biguanidines (antidiabetic) Administration way: Oral Initial dose: 425 mg twice daily Maximum dose: 850 mg, twice daily Treatment duration: 12 months
Group Type
EXPERIMENTAL
Metformin
Intervention Type
DRUG
Metformin oral: 425 mg twice daily (initial dose) and 850 twice daily (maximum dose)
Placebo
Therapeutic group: NA Administration way: Oral Initial dose: 425 mg twice daily Maximum dose: 850 mg, twice daily Treatment duration: 12 months
Group Type
PLACEBO_COMPARATOR
Placebo
Intervention Type
DRUG
425 mg twice daily (initial dose) and 850 twice daily (maximum dose)
Interventions
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Metformin
Metformin oral: 425 mg twice daily (initial dose) and 850 twice daily (maximum dose)
Intervention Type
DRUG
Placebo
425 mg twice daily (initial dose) and 850 twice daily (maximum dose)
Intervention Type
DRUG
Other Intervention Names
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Biguanides (oral antidiabetic)
Not appicable
Eligibility Criteria
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Inclusion Criteria
1. Symptomatic positive clinical diagnosis of Huntington disease.
2. Presence of 36 CAG repeats (or more) in the hunting gene based on centralized CAG analysis.
3. Men or women between 21-65 years of age, inclusive, with an onset of HD at 18 years of age or older.
4. Women of childbearing potential (women who are not postmenopausal children or who have not undergone surgical sterilization at times) will need to be using a contraceptive method for 30 days before beginning study treatment, and will have contact with at least two methods of birth control throughout the duration of the study and up to 30 days after taking the last dose of treatment.
5. A sum of \> 4 points on the UHDRS-TMS scale and a diagnostic confidence level of 4.
6. Scale of independence ≥ 75%.
7. Score on the UHDRS-TFC scale ≥ 8 at the screening visit.
8. They must be trained and willing to provide written informed consent prior to any procedure related to the study to be performed at the screening visit. Patients with a legal guardian must be determined according to local requirements.
9. They must be trained and will require taking oral medication and will need to be determined to comply with the specific study procedures.
10. They must be able to travel to the study center and, in the judgment of the investigator, demonstrate that it is probable that they can continue traveling during the study.
11. Availability and willingness of a caregiver, informant, or family member to provide information during study visits that evaluate PBA-s. It is recommended that the caregiver be someone who cares for the patient at least 2 to 3 times a week and at least 3 hours per occasion. The suitability of the caregiver must be judged by the investigator.
2. Presence of 36 CAG repeats (or more) in the hunting gene based on centralized CAG analysis.
3. Men or women between 21-65 years of age, inclusive, with an onset of HD at 18 years of age or older.
4. Women of childbearing potential (women who are not postmenopausal children or who have not undergone surgical sterilization at times) will need to be using a contraceptive method for 30 days before beginning study treatment, and will have contact with at least two methods of birth control throughout the duration of the study and up to 30 days after taking the last dose of treatment.
5. A sum of \> 4 points on the UHDRS-TMS scale and a diagnostic confidence level of 4.
6. Scale of independence ≥ 75%.
7. Score on the UHDRS-TFC scale ≥ 8 at the screening visit.
8. They must be trained and willing to provide written informed consent prior to any procedure related to the study to be performed at the screening visit. Patients with a legal guardian must be determined according to local requirements.
9. They must be trained and will require taking oral medication and will need to be determined to comply with the specific study procedures.
10. They must be able to travel to the study center and, in the judgment of the investigator, demonstrate that it is probable that they can continue traveling during the study.
11. Availability and willingness of a caregiver, informant, or family member to provide information during study visits that evaluate PBA-s. It is recommended that the caregiver be someone who cares for the patient at least 2 to 3 times a week and at least 3 hours per occasion. The suitability of the caregiver must be judged by the investigator.
Exclusion Criteria
1. The participant has taken metformin in the last three months before the start of the study.
2. The participant has diabetes of any kind.
3. The participant is pregnant or lactating.
4. The participant has a medical condition other than HD (metabolism, kidney function, liver function, heart problems, etc.), or any contraindication against metformin.
5. The participant has an uncontrolled psychiatric condition.
6. Participant is allergic to metformin or any of the other ingredients of this medicine.
7. The participant has kidney problems \[creatinine clearance \<60 ml / min calculated using Cockcroft-Gault formula\] or liver problems.
8. The participant is dehydrated, from prolonged or severe diarrhea, or has vomited several times.
9. The participant has a serious infection.
10. The participant has been treated for heart failure or has recently had a heart attack, has severe circulation problems, or is having difficulty breathing.
11. The participant drinks\> 6 units / day of alcohol (alcoholism).
12. Participants diagnosed with oncological disease.
13. Participants with a suicidal propensity, with an affirmative answer in items 4 or 5 in the C-SSRS at the screening visit.
2. The participant has diabetes of any kind.
3. The participant is pregnant or lactating.
4. The participant has a medical condition other than HD (metabolism, kidney function, liver function, heart problems, etc.), or any contraindication against metformin.
5. The participant has an uncontrolled psychiatric condition.
6. Participant is allergic to metformin or any of the other ingredients of this medicine.
7. The participant has kidney problems \[creatinine clearance \<60 ml / min calculated using Cockcroft-Gault formula\] or liver problems.
8. The participant is dehydrated, from prolonged or severe diarrhea, or has vomited several times.
9. The participant has a serious infection.
10. The participant has been treated for heart failure or has recently had a heart attack, has severe circulation problems, or is having difficulty breathing.
11. The participant drinks\> 6 units / day of alcohol (alcoholism).
12. Participants diagnosed with oncological disease.
13. Participants with a suicidal propensity, with an affirmative answer in items 4 or 5 in the C-SSRS at the screening visit.
Minimum Eligible Age
21 Years
Maximum Eligible Age
65 Years
Eligible Sex
ALL
Accepts Healthy Volunteers
No
Sponsors
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Instituto de Investigacion Sanitaria La Fe
OTHER
Sponsor Role
lead
Responsible Party
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Responsibility Role
SPONSOR
Principal Investigators
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Carmen Peiró, Phd, MD
Role: STUDY_CHAIR
Instituto de Investigación Sanitaria La Fe
Locations
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Hospital General Universitario Dr. Balmis
Alicante, Alicante, Spain
Site Status
Hospital General Universitario de Elche
Elche, Alicante, Spain
Site Status
Hospital Universitari Son Espases
Palma de Mallorca, Balearic Islands, Spain
Site Status
Hospital Universitario Mare de Déu de la Mercé
Barcelona, Barcelona, Spain
Site Status
Hospital Universitario Burgos
Burgos, Castille and León, Spain
Site Status
Complejo Hospitalario de Albacete
Albacete, Castille-La Mancha, Spain
Site Status
Hospital Universitario Ramón y Cajal
Madrid, Madrid, Spain
Site Status
Hospital Universitario Central de Asturias
Oviedo, Principality of Asturias, Spain
Site Status
Hospital Universitario y Politécnico La Fe
Valencia, València, Spain
Site Status
Countries
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Spain
References
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Other Identifiers
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TEMET-HD
Identifier Type: -
Identifier Source: org_study_id
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