Analysis of Volatile Organic Compounds in Exhaled Air and Sweat: Interest in Rapid Screening for COVID-19 Infection.
NCT ID: NCT04817371
Last Updated: 2022-08-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
192 participants
INTERVENTIONAL
2021-03-01
2022-09-30
Brief Summary
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The study of volatile organic compounds (VOC) detected in exhaled air or in sweat, is an innovative research area for respiratory diseases. The analysis of VOC can be done either by the technique of the mass spectrometry which allows the identification of each VOC in the exhaled air or by the technique of electronic nose, simpler and faster, which provides an idea of the general profile of the VOC without identifying them. The VOC have shown their interest in some situations, such as diagnostic or prognostic tool in patients followed for thoracic tumorous pathology or bronchial or pulmonary vascular diseases.
Moreover, it has recently been shown that properly trained dogs would be able to detect an olfactory signature of SARS-CoV-2 infection with a specificity greater than 90%; this olfactory signature corresponds to VOCs detectable by the flair of dogs (Nosaïs-Covid19 study).
Validation of the diagnostic value of VOC analyzes by non-invasive and rapid methods (electronic nose analysis or mass spectrometry; detection by the scent of dogs) for the rapid detection and early diagnosis of a SARS-CoV-2 infection warrants the performance of this clinical study.
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
OTHER
NONE
Study Groups
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Symptomatic patients with positive PCR
Patients with symptoms of COVID-19 and whose PCR result is positive
Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Symptomatic patients with positive PCR for other respiratory virus
Patients with symptomatic respiratory disease of infectious origin with negative RT-PCR for SARS-CoV-2 and positive RT-PCR for other respiratory viruses
Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Asymptomatic patients or healthy volunteers
Patients or healthy volunteers with negative RT-PCR and negative serology
Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Volunteers or patients vaccinated against COVID-19
Volunteers or patients vaccinated against COVID-19 (complete vaccination scheme)
Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Interventions
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Volatile Organic Compounds analysis (e-noses)
VOC analysis in exhaled air with e-noses.
Canine odor detection of Volatile Organic Compounds
VOC analysis in sweat by trained dogs.
Volatile Organic Compounds analysis (mass spectrometry)
VOC analysis in exhaled air with mass spectrometry.
Volatile Organic Compounds analysis in sweat (mass spectrometry)
VOC analysis in sweat with mass spectrometry.
Eligibility Criteria
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Inclusion Criteria
* Patients managed at the Foch Hospital with RT-PCR screening for SARS-CoV-2 infection
* Healthy volunteers among the hospital staff, asymptomatic, for whom an RT-PCR SARS-CoV-2 is indicated or recommended.
* Healthy hospital volunteers vaccinated against COVID (full vaccination schedule completed)
* At least 18 years of age;
* Fluency in the French language;
* Have signed a consent form;
* Be affiliated with a health insurance plan.
Exclusion Criteria
* Patient deprived of liberty by judicial or administrative decision
18 Years
ALL
Yes
Sponsors
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Hopital Foch
OTHER
Responsible Party
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Principal Investigators
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Philippe Devillier, PhD
Role: PRINCIPAL_INVESTIGATOR
Hopital Foch
Locations
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Foch hospital
Suresnes, , France
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2021_0013
Identifier Type: -
Identifier Source: org_study_id
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