Influence of Power and Wavelength on Photobiomodulation Therapy for Muscle Performance in Healthy Subjects

NCT ID: NCT04809415

Last Updated: 2022-10-21

Basic Information

• Recruitment Status: COMPLETED
• Clinical Phase: NA
• Total Enrollment: 42 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-05-01
• Study Completion Date: 2022-10-01

Brief Summary

In recent years, photobiomodulation has been studied as a means of increasing muscle performance in athletes and healthy individuals. This is possible due to the physiological changes that photobiomodulation therapy can promote. Moreover, given a large number of existing studies on the subject, some directions for future research have been established. For example, future research was established, the relationship between power and time because with high power, it will achieve the same energy with shorter application times. However, irradiation may not be offered for the minimum recommended time. Therefore, this study aims to compare different powers and, consequently, different application times for muscle performance in healthy individuals. For this, 42 participants will be recruited, males between 18 to 40 years old, without recent musculoskeletal injury or cardiorespiratory problems. The participants will participate in 3 evaluations containing functional and physiological variables and ten training sessions of lower limbs with previous photobiomodulation therapy application, comparing devices with a power of 0.864W and 1.864W. 0.864W and 1.2W. Lower limbs training will be composed of stiff and squat exercises twice a week, for five weeks. In the pre- and post-intervention evaluations, the following parameters will be evaluated isokinetic apparatus, body composition, and functionality of the vertical jump. For data analysis, we will use a normality test to verify the distribution and statistical tests will be used for intra and intra and intergroup comparisons, considering two factors in the comparisons time and group. A significance level of 5% will be adopted.

Detailed Description

It is a blinded randomized clinical trial. The volunteers will undergo pre-evaluation, 5 weeks of training associated with the LED application, being distributed in two applications per week, and a re-evaluation 24 hours after the last application, totaling a total of approximately 7 weeks. Thus, on the first day (Pre-test) volunteers will be submitted to anthropometric evaluation and evaluation by bioimpedance for analysis of detailed body composition. Then, the maximum voluntary contraction test (CVM) will be performed on the isokinetic dynamometer, together with the electromyographic evaluation. Before and after the evaluation with the isokinetic dynamometer, thermography will be collected. Still, will be evaluated the vertical jump test after 15 minutes of passive rest.

After the initial evaluations, the researcher will go apply the respective interventions, which consist of applying LEDs all over the quadriceps and hamstring bilaterally, while the sham group (GS) will receive the LED application off, without the emission of light. The application will occur for five weeks and will occur twice weekly, on days spaced for at least 48 hours. The same will be done in conjunction with the lower limb strength training protocol. It is noteworthy that although the therapy follows the same energy values, two different pieces of equipment will be used, thus changing the wavelength, total power and power density, and the consequent coverage time and area.

The tests performed at the time of pre-application of the LED (Pre-test) will be reapplied in the same order 24 hours after the last application of the interventions. After seven days of the last application, the isokinetic evaluation, electromyography, and vertical jump evaluation will be performed. In addition, at the end of the second and fourth weeks, the volunteer will carry out an evaluation with the isokinetic dynamometer, electromyography, plethysmography, and thermography.

Conditions

Low Level Laser Therapy; Photobiomodulation; Performance; Sport

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: TRIPLE

Study Groups

Sham Group (G-S)

The LED blanket will be positioned across the quadriceps and hamstring bilaterally, however, there will be no light emission. However, the volunteer will perform the strength training protocol.

Group Type: SHAM_COMPARATOR

Sham

Intervention Type: OTHER

Simulation of the application of photobiomodulation therapy.

300J Infrared Blanket LED Group (Blanket-300J)

The LED blanket with a wavelength of 940nm, energy of 300J, will be applied across the quadriceps and hamstrings bilaterally, just before the strength training protocol.

Group Type: EXPERIMENTAL

Photobiomodulation

Intervention Type: OTHER

Photobiomodulation consists of irradiation by light in order to achieve photochemical and photophysical outcomes.

300J Infrared Cluster LED Group (Cluster-300J)

The LED Cluster with a wavelength of 850 nm, energy of 300 J, will be applied to the quadriceps (5 points) and hamstrings (5 points), bilaterally, just before the strength training protocol.

Group Type: EXPERIMENTAL

Photobiomodulation

Intervention Type: OTHER

Photobiomodulation consists of irradiation by light in order to achieve photochemical and photophysical outcomes.

Interventions

Photobiomodulation

Photobiomodulation consists of irradiation by light in order to achieve photochemical and photophysical outcomes.

Intervention Type: OTHER

Sham

Simulation of the application of photobiomodulation therapy.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• healthy individuals;

Exclusion Criteria

• musculoskeletal injury in the last three months;
• cardiovascular diseases;
• use of anabolic, anti-inflammatory and analgesic drugs 72 hours before the evaluations;
• use of alcohol and illicit drugs during the collection period;

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 40 Years
• Eligible Sex: MALE
• Accepts Healthy Volunteers: Yes

Sponsors

University of Sao Paulo

OTHER

Sponsor Role: lead

Responsible Party

Rinaldo Roberto de Jesus Guirro

Professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Carlos E Girasol, Student

Role: PRINCIPAL_INVESTIGATOR

University of Sao Paulo

Locations

University of Sao Paulo

Ribeirão Preto, São Paulo, Brazil

Countries

Brazil

References

American College of Sports Medicine. American College of Sports Medicine position stand. Progression models in resistance training for healthy adults. Med Sci Sports Exerc. 2009 Mar;41(3):687-708. doi: 10.1249/MSS.0b013e3181915670.

Reference Type: BACKGROUND

PMID: 19204579 (View on PubMed)

Ferraresi C, Beltrame T, Fabrizzi F, do Nascimento ES, Karsten M, Francisco Cde O, Borghi-Silva A, Catai AM, Cardoso DR, Ferreira AG, Hamblin MR, Bagnato VS, Parizotto NA. Muscular pre-conditioning using light-emitting diode therapy (LEDT) for high-intensity exercise: a randomized double-blind placebo-controlled trial with a single elite runner. Physiother Theory Pract. 2015 Jul;31(5):354-61. doi: 10.3109/09593985.2014.1003118. Epub 2015 Jan 14.

Reference Type: BACKGROUND

PMID: 25585514 (View on PubMed)

Anders JJ, Lanzafame RJ, Arany PR. Low-level light/laser therapy versus photobiomodulation therapy. Photomed Laser Surg. 2015 Apr;33(4):183-4. doi: 10.1089/pho.2015.9848. No abstract available.

Reference Type: BACKGROUND

PMID: 25844681 (View on PubMed)

Other Identifiers

DifPower

Identifier Type: -

Identifier Source: org_study_id