A U.S Post Approval Study Evaluating the SYNERGY XLV (MEGATRON) Stent System

NCT ID: NCT04807439

Last Updated: 2023-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-04-14

Study Completion Date

2023-08-18

Brief Summary

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This is a post-market, standard of care, real-world observational study to assess the clinical outcomes of the SYNERGY XLV (MEGATRON) Coronary Stent System for the treatment of subjects with atherosclerotic lesion(s) ≤ 28 mm in length (by visual estimate) in native coronary arteries ≥3.50 mm to ≤5.00 mm in diameter (by visual estimate). This Post Approval study is a cohort associated with the Evolve 4.5/5.0 (SYNERGY LV) Post Approval Study, which is registered under ClinicalTrials.gov ID: NCT03875651.

Detailed Description

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Conditions

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Atherosclerosis Heart Diseases, Coronary Coronary Artery Disease Cardiovascular Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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SYNERGY XLV (Megatron) Coronary Stent System

The SYNERGY Everolimus-Eluting Platinum Chromium Coronary Stent System (SYNERGY Stent System), manufactured by BSC, is a device/drug combination product comprised of two regulated components: a device (Coronary Stent System) and a drug product (a formulation of everolimus contained in a bioabsorbable polymer coating).

SYNERGY XLV (Megatron) Coronary Stent System

Intervention Type DEVICE

The SYNERGY MEGATRON Everolimus-Eluting Platinum Chromium Coronary Stent System is indicated for improving luminal diameter in patients, including those at high risk for bleeding, with diabetes mellitus, with symptomatic heart disease, stable angina, unstable angina, non-ST elevation MI or documented silent ischemia due to atherosclerotic lesions in native coronary arteries \>3.50 mm to \<5.00 mm in diameter in lesions \<28 mm in length.

Interventions

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SYNERGY XLV (Megatron) Coronary Stent System

The SYNERGY MEGATRON Everolimus-Eluting Platinum Chromium Coronary Stent System is indicated for improving luminal diameter in patients, including those at high risk for bleeding, with diabetes mellitus, with symptomatic heart disease, stable angina, unstable angina, non-ST elevation MI or documented silent ischemia due to atherosclerotic lesions in native coronary arteries \>3.50 mm to \<5.00 mm in diameter in lesions \<28 mm in length.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient requires treatment with a SYNERGY XLV (Megatron) stent

Exclusion Criteria

* Planned treatment with a non-SYNERGY stent
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Robert C Stoler, MD

Role: PRINCIPAL_INVESTIGATOR

Baylor Heart and Vascular Hospital

Locations

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Yale University

New Haven, Connecticut, United States

Site Status

Clearwater Cardiovascular Consultants

Clearwater, Florida, United States

Site Status

Beth Israel Deaconness Medical Center

Boston, Massachusetts, United States

Site Status

North Kansas City Hospital

Kansas City, Missouri, United States

Site Status

Wake Medical Center

Raleigh, North Carolina, United States

Site Status

Oregon Health Sciences University

Portland, Oregon, United States

Site Status

Baylor Heart and Vascular Hospital

Dallas, Texas, United States

Site Status

Inova Fairfax Hospital

Fairfax, Virginia, United States

Site Status

Countries

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United States

Other Identifiers

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92226704

Identifier Type: -

Identifier Source: org_study_id

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