Cruz HBR Registry - Post-market Registry to Evaluate the Safety and Efficacy of the Supraflex Cruz Stent

NCT ID: NCT04138238

Last Updated: 2023-07-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

1200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-19

Study Completion Date

2022-05-31

Brief Summary

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This is a prospective, multicenter, open-label, single-arm registry. The primary objective of this registry is to confirm the results of the Supraflex Cruz stent in real life all-comer patients (800 patients as in the Supraflex arm of the TALENT trial) and demonstrate that the Supraflex Cruz stent is not inferior to the BioFreedom stent in High Bleeding Risk (HBR) patients (400 patients) with respect to device oriented composite endpoint (DOCE) at 12 months. All patients will be followed up to 12 months after the index procedure.

Detailed Description

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Conditions

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Coronary Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Supraflex Cruz Sirolimus-eluting Stent

Supraflex Cruz Sirolimus-eluting Stent

Intervention Type DEVICE

Patient implanted with at least one Supraflex Cruz sirolimus-eluting stent as a part of planned clinical care

Interventions

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Supraflex Cruz Sirolimus-eluting Stent

Patient implanted with at least one Supraflex Cruz sirolimus-eluting stent as a part of planned clinical care

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Patients ≥ 18 years old
2. De novo or re-stenotic significant stenosis in at least one native coronary artery
3. Patients with silent ischemia, stable angina, unstable angina or non-STEMI eligible for PCI (no limitation of the number of treated lesions and vessels, except higher tercile of Syntax score assessed by the site)
4. Target lesions suitable for PCI with Drug-eluting Stent (DES) diameter between 2.00 and 4.50 mm
5. Total lesion length should be from 15 to 120 mm
6. Patient is willing and capable to sign the written informed consent and comply with all requirements of the registry
7. Planned staged procedures are allowed within 3 months using Supraflex Cruz stent only

Exclusion Criteria

1. SYNTAX Score \> 32
2. Hemodynamic instability or cardiogenic shock
3. Known hypersensitivity or contraindication to any component of the study stent or the eluting drug, to media contrast, to dual antiplatelet therapy (DAPT) medication required by current practice
4. Subject is pregnant, nursing or is a woman with child-bearing potential
5. Any co-morbid condition with life expectancy \< 1 year or that may result in protocol non-compliance
6. Patients who are participating in another drug or device investigational study, which has not reached its primary endpoint
7. Patients under judicial protection, tutorship or curatorship
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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European Cardiovascular Research Center

NETWORK

Sponsor Role collaborator

Sahajanand Medical Technologies Limited

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Prof. Christoph K Naber, PD. Dr. Med.

Role: PRINCIPAL_INVESTIGATOR

Klinikum Wilhelmshaven

Locations

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Centre Hospitalier Haguenau

Haguenau, , France

Site Status

Hôpital Privé Jacques Cartier

Massy, , France

Site Status

CHRU de Montpellier

Montpellier, , France

Site Status

Hôpital Privé Claude Galien

Quincy-sous-Sénart, , France

Site Status

Clinique Saint Hilaire

Rouen, , France

Site Status

CHU de Toulouse - Rangueil

Toulouse, , France

Site Status

Kerckhoff Heart Center

Bad Nauheim, , Germany

Site Status

Heart and Diabetes Center Nordrhine Westfalia

Bad Oeynhausen, , Germany

Site Status

Segeberg Kliniken

Bad Segeberg, , Germany

Site Status

Charité Campus Mitte

Berlin, , Germany

Site Status

Charité Campus Benjamin Franklin

Berlin, , Germany

Site Status

Charité Campus Virchow

Berlin, , Germany

Site Status

St Johannes Hospital

Dortmund, , Germany

Site Status

Herzzentrum Dresden - Universitätklinikum an der TU Dresden

Dresden, , Germany

Site Status

Praxisklinik Dresden

Dresden, , Germany

Site Status

HELIOS Klinikum Erfurt

Erfurt, , Germany

Site Status

University Hospital Erlangen

Erlangen, , Germany

Site Status

Elizabeth Krankenhaus

Essen, , Germany

Site Status

UKSH

Kiel, , Germany

Site Status

Universität Leipzig - Herzzentrum

Leipzig, , Germany

Site Status

Städtische Kliniken Neuss, Lukaskrankenhaus

Neuss, , Germany

Site Status

Universitätsklinikum

Regensburg, , Germany

Site Status

Klinikum Wilhelmshaven

Wilhelmshaven, , Germany

Site Status

University and Hospital Fribourg

Fribourg, , Switzerland

Site Status

Kantonsspital St. Gallen

Sankt Gallen, , Switzerland

Site Status

University Hospital Zurich

Zurich, , Switzerland

Site Status

Countries

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France Germany Switzerland

Other Identifiers

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SMT CT 2019-20/108

Identifier Type: -

Identifier Source: org_study_id

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