Multicentric Non-randomized Investigation of RESISTANT Camouflage Stent-system

NCT ID: NCT02011984

Last Updated: 2015-02-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

120 participants

Study Classification

OBSERVATIONAL

Study Start Date

2013-12-31

Study Completion Date

2017-02-28

Brief Summary

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Non-randomized multicenter post-market study to confirm the long-term safety and effectiveness of the CE-approved Camouflage-coated self-expandable RESISTANT Camouflage stent system for revascularization of de novo stenotic lesions in the superficial femoral artery in 100 compliant patients suitable for stent angioplasty.

The CE-approved device will be used according to its intended use. Beyond the standard of care no further interventions are scheduled. Therefore, this trial is subject to the exception to the rule §23b of the German Medical Device Act (MPG), which includes the national implementation of EC directive 93/42/EEC.

Detailed Description

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The aim of this non-randomized post-market clinical follow-up study is to confirm long-term safety and effectiveness of the CE-approved Camouflage-coated self expandable RESISTANT Camouflage stent system for revascularization of de novo stenotic lesions in superficial femoral artery in 120 compliant patients suitable for stent angioplasty. The primary end point is the target lesion revascularization after 12 months. Further follow-ups are scheduled at discharge, 30 days, 6 and 24 months.

Conditions

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Peripheral Artery Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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peripheral artery disease

de novo stenotic lesions in superficial femoral artery

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Age of 18 to 95 years
* Male or non-pregnant female
* De novo lesions\>70% or occlusions in the SFA (Superficial Femoral Artery) arteries suitable for stent angioplasty
* Max. 1 lesion within each leg should be treated as study lesions
* Lesions length range from ≥3 cm to ≤18 cm
* A patent inflow artery free from significant lesions (\>50 % stenosis) as confirmed by angiography. Treatment of target lesion acceptable after successful treatment of inflow artery lesions.
* Reference vessel diameter ≥3 mm and ≤ 7 mm
* Successful guide wire passage of the lesion
* Symptomatic peripheral artery disease (Rutherford stage 2 to 5)
* Patient is willing to provide informed consent and comply with the required follow-up visits, testing schedule, and medication regimen

Exclusion Criteria

* Patients for whom an anti-platelet therapy, anticoagulants or thrombolytics are contraindicated
* Patients presenting a lasting intraluminal thrombosis at the lesion after a thrombolytic therapy
* Perforation at the location of the angioplasty characterized by secretion of the contrast medium
* Aneurysm of the artery to be treated
* All common contraindications for a PTA (Percutaneous Transluminal Angioplasty)
* Contraindications for stent angioplasty
* Hypersensitivity/allergy to nickel-titanium
* Hypersensitivity/allergy to any of the components of the delivery \& dilation system
* Severe renal insufficiency (creatinine\>2.0 mg/dL or glomerular filtration rate \< 60 ml/min/1.73)
* Uncorrected bleeding disorder
* Major gastrointestinal bleeding within the last 6 months.
* Ipsilateral intervention other than target vessel
* Untreated ipsilateral iliac artery stenosis \>70 %
* Previous stenting or prior surgery of the SFA
* In-stent restenosis
* Acute myocardial infarct within 72 h
* Less than one patent crural artery
* Popliteal stenosis \> 70 %
* Manifest hyperthyroidism
* Acute onset of symptoms
* Leg-threatening ischemia
* Multimorbid patient with poor general condition
* Pregnant woman or becoming pregnant in \< 2 yrs
* Living more than 100 km apart from the study center
* Patient actively participating in another investigational device or drug study
* History of hemorrhagic stroke within 3 months
* Previous or planned surgical or interventional procedure within 30 days of the procedure
* Acute or sub-acute thrombus in target vessel
* Acute vessel occlusion or sudden symptom onset
* Lesions in target area requiring atherectomy (or ablative devices), cutting balloons, cryoplasty balloons, or any other advanced device to facilitate angioplasty balloon or stent delivery
* Use of adjunctive therapies (i.e. laser, atherectomy, cryoplasty, scoring/cutting balloon, etc.)
Minimum Eligible Age

18 Years

Maximum Eligible Age

95 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eucatech AG

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Giese, Phd

Role: STUDY_CHAIR

Eucatech AG

Locations

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Uniklinikum Freiburg, Abteilung Röntgendiagnostik

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Site Status RECRUITING

Uniklinikum Gießen und Marburg, Diagnostische und Interventionelle Radiologie

Marburg, Hesse, Germany

Site Status RECRUITING

Augusta-Krankenhaus, Klinik für Gefäßchrirugie

Düsseldorf, North Rhine-Westphalia, Germany

Site Status RECRUITING

Heinrich Braun Klinikum Zwickau, Radiologie und Neuroradiologie

Zwickau, Saxony, Germany

Site Status RECRUITING

CCP - Istituto di Cura "Città di Pavia"

Pavia, Lombardy, Italy

Site Status RECRUITING

Countries

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Germany Italy

Central Contacts

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Claudia Marx, MD

Role: CONTACT

00497621167333 ext. 20

Facility Contacts

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Wulf Euringer, M.D.

Role: primary

0049 761 270 ext. 38580

Mykhaylo Burbelko, M.D.

Role: primary

0049 6421 58 ext. 65912

Ralf Kolvenbach, Prof.

Role: primary

0049 211 9043 ext. 301

Jörg Thalwitzer, M.D.

Role: primary

0049 375 ext. -4854/-4855

Cesare Massa Saluzzo, M.D.

Role: primary

0039 3349419996

Other Identifiers

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ECT024ResiCSfaRegV10

Identifier Type: OTHER

Identifier Source: secondary_id

recam2013_eucatech

Identifier Type: -

Identifier Source: org_study_id

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