Brain Aneurysms: Utility of Cisternal Urokinase Irrigation

NCT ID: NCT04792944

Last Updated: 2021-03-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

247 participants

Study Classification

OBSERVATIONAL

Study Start Date

2007-01-01

Study Completion Date

2020-12-31

Brief Summary

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Despite the efforts made in its treatment, aneurysmal subarachnoid haemorrhage continues to induce high mortality and morbidity rates. Today there are treatment protocols in all hospitals. The vast majority prefer, whenever possible, the endovascular route, given its lesser aggressiveness and morbidity.

Although embolization prevents aneurysm' rebleeding, it does remove the subarachnoid blood clot. Therefore, it does not modify the evolution, incidence and severity of vasospasm.

The idea is to carry out a 10-year retrospective study classifying patients into five groups based on the type of treatment received, analyzing the results' differences. The aim is to improve what is done as much as possible and to be able to propose potential areas for improvement. Besides, this study will be the basis of a future prospective study, prepared without the current one's biases and errors.

Detailed Description

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Aneurysmal subarachnoid hemorrhage continues to have very high morbidity and mortality rates, despite the years elapsed and repeated attempts to reduce it.

Stabilizing the aneurysm by embolization or surgical clipping leaves unresolved the vasospasm, responsible for ischemic brain damage, causing neurological sequelae and cognitive impairment.

It has long been known that the deoxyhemoglobin liberated from the extravasated red blood cells retained in the subarachnoid clot is the leading cause of vasospasm. Different routes have been tried to minimize its deleterious effects, such as copious lavage of the skull base cisterns, lysing the subarachnoid clot with urokinase or rtPA, administration of vitamin C, iron chelators, or superoxydodismutase-like drugs.

The volume of subarachnoid hemorrhage was soon correlated with the vasospasm severity. Once this fact was known in the 1980s and 1990s, cisternal lavage was used extensively during aneurysms' surgical clipping. Clots located in the subarachnoid space were lysed with urokinase or rtPA (recombinant tissue plasminogen activator), showing positive effects, particularly evident for the most severe bleeds, those with Fisher's grades of 3 or higher.

However, the introduction of embolization changed the treatment paradigm. As the craniotomy is not carried out, the cisterns are not usually washed, which controls the rebleeding but not the vasospasm. To date, we are not aware of any study that compares the effect on vasospasm of embolization versus clipping of aneurysms with lavage of the cisterns using thrombolytic agents.

In the Neurosurgery Department of our Hospital, two periods can be identified in which the treatment of brain aneurysms has been carried out differently. In the first period between 2007 and 2011, the aneurysms were primarily subjected to embolization, and only if there was no indication for endovascular treatment, surgical clipping was performed. In the second period, between 2012 and 2018, they were operated on an emergency basis with clip application and the skull base cisterns washed with urokinase. Embolization was considered if the surgical clipping was judged too risky.

The aim is to analyze these two periods and compare the mortality, morbidity, and vasospasm rates, the need for a cerebrospinal fluid diversion (temporary and definitive), and the final neurological and cognitive status for the different therapeutic approaches.

Conditions

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Subarachnoid Hemorrhage, Aneurysmal Vasospasm, Cerebral Hydrocephalus

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Study Groups

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No treatment

Those are the patients that do not receive any treatment for the aneurysm, neither endovascular nor surgical

No interventions assigned to this group

External ventricular drain only with neither embolization nor clipping

These patients will be treated with an external ventricular drain only with neither embolization nor clipping

External ventricular drain

Intervention Type PROCEDURE

Insertion of an external ventricular drain to treat acute hydrocephalus

Embolization

These patients will be treated endovascularly

Endovascular treatment

Intervention Type PROCEDURE

Aneurysm treatment through endovascular methods

Programmed surgical clipping

These patients will be treated no on an emergency basis with surgical clipping of an aneurysm that has bled

Clipping

Intervention Type PROCEDURE

Surgical clipping of brain aneurysms

Emergency surgical clipping with cisternal urokinase administration

These patients with undergo emergency surgical clipping with cisternal urokinase administration

Urokinase

Intervention Type DRUG

Washing the subarachnoid clot induced by a subarachnoid haemorrhage aneurysmal bleeding with urokinase after aneurysm clipping

Clipping

Intervention Type PROCEDURE

Surgical clipping of brain aneurysms

Patients with incidental brain aneurysm discovery with no SAH and programmed aneurysm clipping

This group will include patients with incidental brain aneurysm discovery with no SAH and programmed aneurysm clipping

Clipping

Intervention Type PROCEDURE

Surgical clipping of brain aneurysms

Interventions

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Urokinase

Washing the subarachnoid clot induced by a subarachnoid haemorrhage aneurysmal bleeding with urokinase after aneurysm clipping

Intervention Type DRUG

Endovascular treatment

Aneurysm treatment through endovascular methods

Intervention Type PROCEDURE

Clipping

Surgical clipping of brain aneurysms

Intervention Type PROCEDURE

External ventricular drain

Insertion of an external ventricular drain to treat acute hydrocephalus

Intervention Type PROCEDURE

Other Intervention Names

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Aneurysm clipping plus cisternal lavage with Urokinase

Eligibility Criteria

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Inclusion Criteria

* \>18 years of age
* harbour one or more saccular brain aneurysms
* with or without subarachnoid hemorrhage (SAH)
* multiple aneurysms

Exclusion Criteria

* absence of brain fusiform, traumatic or mycotic aneurysms
* SAH due to other causes (trauma, anticoagulation, antiplatelet medication, arteriovenous malformation, or tumor)
* any medical, neurological, or psychiatric condition that would impair patient's evaluation
* past medical history of bleeding disorders or liver diseases altering the coagulation
* anticoagulation
* platelet count \<10x109/L
* prothrombin time \>15 seconds
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Valencia

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Teresa V Moratal, Nurse

Role: STUDY_CHAIR

Hospital General Universitario Valencia

Locations

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Hospital General Universitario de Valencia

Valencia, , Spain

Site Status

Countries

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Spain

References

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Reference Type DERIVED
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Other Identifiers

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CEIm 17-07-2019

Identifier Type: -

Identifier Source: org_study_id

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