MedDataX Logo

Long-term Prognosis of Emergency Aneurysmal Subarachnoid Hemorrhage

NCT ID: NCT04785976

Last Updated: 2023-12-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

RECRUITING

Total Enrollment

5000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2012-04-01

Study Completion Date

2032-04-01

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Rupture of intracranial aneurysms can lead to extensive subarachnoid hemorrhage (SAH), a potentially fatal neurological emergency with mortality rates ranging from 8 to 67%. At present, surgical clipping (SC) and endovascular coiling (EC) are two main treatments for aneurysmal subarachnoid hemorrhage (aSAH), in recent years, the improvements in surgical equipment and techniques have already greatly improved the postoperative safety of patients. However, considering individual differences between patients, some still at risk due to possible complications during hospitalization or after discharge from the hospital, it will no doubt generate a large healthcare burden.

This prospective, observational clinical trial (LongTEAM) is to improve the diagnosis and treatment effect and efficiency in this field, reducing mortality, medical costs, and medical burden, while opening up new avenues for interdisciplinary clinical practice and scientific research exploration.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aneurysmal Subarachnoid Hemorrhage

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Surgical clipping

Surgical clipping and endovascular coiling

Intervention Type PROCEDURE

Surgical clipping: Apply aneurysm clip to clip the ruptured aneurysm. Endovascular coiling：Also called endovascular embolization, to block blood flow into an aneurysm.Preventing blood flow into an aneurysm helps to keep it from rupturing.

Endovascular coiling

Surgical clipping and endovascular coiling

Intervention Type PROCEDURE

Surgical clipping: Apply aneurysm clip to clip the ruptured aneurysm. Endovascular coiling：Also called endovascular embolization, to block blood flow into an aneurysm.Preventing blood flow into an aneurysm helps to keep it from rupturing.

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Surgical clipping and endovascular coiling

Surgical clipping: Apply aneurysm clip to clip the ruptured aneurysm. Endovascular coiling：Also called endovascular embolization, to block blood flow into an aneurysm.Preventing blood flow into an aneurysm helps to keep it from rupturing.

Intervention Type PROCEDURE

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* All patients admitted to the emergency department of the investigator with aneurysmal subarachnoid hemorrhage are included in their prospective registry.

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Peking University International Hospital

OTHER

Sponsor Role collaborator

Beijing Tiantan Hospital

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

yuanli Zhao

Director of Department of Cerebrovascular Neurosurgery

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Fa Lin, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Yuanli Zhao, MD

Role: STUDY_CHAIR

Beijing Tiantan Hospital

Jizong Zhao, MD

Role: STUDY_CHAIR

Beijing Tiantan Hospital

Runting Li, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Xiaolin Chen, MD

Role: STUDY_DIRECTOR

Beijing Tiantan Hospital

Yu Chen, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Junlin Lu, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Zhipeng Li, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Heze Han, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Debin Yan, MD

Role: PRINCIPAL_INVESTIGATOR

Beijing Tiantan Hospital

Shuo Wang, MD

Role: STUDY_CHAIR

Beijing Tiantan Hospital

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

Site Status RECRUITING

The First People's Hospital of Neijiang

Neijiang, Sichuan, China

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

China

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Runting Li, MD

Role: CONTACT

Phone: +8615753166690

Email: [email protected]

Xiaolin Chen, MD

Role: CONTACT

Phone: +8613810624845

Email: [email protected]

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Runting Li, MD

Role: primary

Xiaolin Chen, MD

Role: backup

Qian Wu, MD

Role: primary

References

Explore related publications, articles, or registry entries linked to this study.

Tang X, Zhu B, Liu M, Lin F, Li R, Song W, Xue J, Zhou L, Chen X. Increased triglyceride-glucose index is associated with adverse functional outcome for patients with aneurysmal subarachnoid hemorrhage after surgical clipping and endovascular coiling: insights from a large cohort study. Front Neurol. 2025 Sep 10;16:1622819. doi: 10.3389/fneur.2025.1622819. eCollection 2025.

Reference Type DERIVED
PMID: 41001201 (View on PubMed)

Yang Y, Zhu B, Lin F, Li R, Chen X. Association between geriatric nutritional risk index and clinical outcome of elderly aneurysmal subarachnoid hemorrhage patients: insights from a large cohort study. Neurosurg Rev. 2025 Feb 4;48(1):169. doi: 10.1007/s10143-025-03209-6.

Reference Type DERIVED
PMID: 39903290 (View on PubMed)

Li R, Lin F, Chen Y, Lu J, Yang J, Han H, Yuan K, Wang K, Yan D, Li R, He S, Li Z, Zhang H, Chen X, Ma L, Zhao Y, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Li Y, Wang S, Chen X, Zhao Y. The effect of sex differences on complications and 90-day outcomes after aneurysmal subarachnoid hemorrhage: a propensity score-matched analysis. Neurosurg Rev. 2022 Oct;45(5):3339-3347. doi: 10.1007/s10143-022-01836-x. Epub 2022 Jul 23.

Reference Type DERIVED
PMID: 35870093 (View on PubMed)

Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y. A 90-Day Prognostic Model Based on the Early Brain Injury Indicators after Aneurysmal Subarachnoid Hemorrhage: the TAPS Score. Transl Stroke Res. 2023 Apr;14(2):200-210. doi: 10.1007/s12975-022-01033-4. Epub 2022 May 14.

Reference Type DERIVED
PMID: 35567655 (View on PubMed)

Li R, Lin F, Chen Y, Lu J, Han H, Ma L, Zhao Y, Yan D, Li R, Yang J, He S, Li Z, Zhang H, Yuan K, Wang K, Hao Q, Ye X, Wang H, Li H, Zhang L, Shi G, Zhou J, Zhao Y, Zhang Y, Li Y, Wang S, Chen X, Zhao Y. Elevated blood hemoglobin on admission as an independent predictor of unfavorable outcomes in patients with aneurysmal subarachnoid hemorrhage. Neurosurg Rev. 2022 Aug;45(4):2689-2699. doi: 10.1007/s10143-022-01780-w. Epub 2022 Apr 2.

Reference Type DERIVED
PMID: 35366711 (View on PubMed)

Yang J, Lu J, Li R, Lin F, Chen Y, Han H, Yan D, Li R, Li Z, Zhang H, Yuan K, Li H, Zhang L, Shi G, Zhou J, Wang S, Zhao Y, Chen X. Application of Intracranial Pressure-Directed Therapy on Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage. Front Aging Neurosci. 2022 Mar 14;14:831994. doi: 10.3389/fnagi.2022.831994. eCollection 2022.

Reference Type DERIVED
PMID: 35360218 (View on PubMed)

Lin F, Chen Y, He Q, Zeng C, Zhang C, Chen X, Zhao Y, Wang S, Zhao J. Prognostic Value of Elevated Cardiac Troponin I After Aneurysmal Subarachnoid Hemorrhage. Front Neurol. 2021 May 31;12:677961. doi: 10.3389/fneur.2021.677961. eCollection 2021.

Reference Type DERIVED
PMID: 34135855 (View on PubMed)

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

KY 2020-11-26

Identifier Type: -

Identifier Source: org_study_id