An Efficacy and Safety Study of Omega-3-acid Ethyl Ester in Chinese Subjects With Hypertriglyceridemia.

NCT ID: NCT04756180

Last Updated: 2021-03-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

248 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-10-31

Study Completion Date

2019-04-30

Brief Summary

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The primary objective was to investigate the effect of 12-week treatment of Omacor on fasting serum triglycerides (TG) in Chinese subjects with hypertriglyceridemia (HTG). The secondary objectives were to investigate the safety and tolerability and effect of Omacor on lipid parameters after 12 weeks treatment.

Detailed Description

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This was a multicenter, randomized, double-blind, parallel-group study of twice daily treatment of Omacor or matching placebo in subjects with moderate or severe HTG.

Conditions

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Hypertriglyceridemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Double Blinded

Study Groups

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Omacor

Omacor 2gm/day for first 4 week followed by 4gms/day for 8 weeks

Group Type EXPERIMENTAL

Omega-3-acid ethyl ester or Placebo

Intervention Type DRUG

Omega-3-acid ethyl ester 2 gm/day for first 4 week followed by 4gm/day for 8 week

Placebo

Omacor Placebo 2gm/day for first 4 week followed by 4gms/day for 8 weeks

Group Type PLACEBO_COMPARATOR

Omega-3-acid ethyl ester or Placebo

Intervention Type DRUG

Omega-3-acid ethyl ester 2 gm/day for first 4 week followed by 4gm/day for 8 week

Interventions

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Omega-3-acid ethyl ester or Placebo

Omega-3-acid ethyl ester 2 gm/day for first 4 week followed by 4gm/day for 8 week

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Baseline fasting serum TG level \> 200mg/dL and \<1000mg/dL, in subjects treated for HTG.
* If on previous statin therapy, the treatment should have been kept stable in the last 3 months before entering the study.
* Able and willing to give written informed consent.

Exclusion Criteria

* Subjects taking fish oil capsules 8 weeks prior to inclusion in this study.
* Known allergy to the active ingredient, or fish, soya, corn or olive oild (placebos).
* Pregnant of lactating females.
* Known increased risk of hemorrhage such as recent surgery, gastrointestinal hemorrhagic disease.
* Significant hepatic disease.
* Significantly reduced renal function.
* Alcohol consumption \>30g for male and 20g for female daily.
* Concomitant use of other investigational drugs.
* Subject related to the investigator.
* Subject expected to be not compliant.
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Abbott

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Pooi Lee Chin

Role: STUDY_DIRECTOR

Abbott

Other Identifiers

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PUFA3001

Identifier Type: -

Identifier Source: org_study_id

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