Efficacy and Safety Study of DHA-O in Adults With Hypertriglyceridemia

NCT ID: NCT01737099

Last Updated: 2014-04-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

93 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-11-30

Study Completion Date

2013-11-30

Brief Summary

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The purpose of this study is to investigate the efficacy and safety of DHA-O to lower elevated triglyceride levels in healthy adults with hypertriglyceridemia.

Detailed Description

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Conditions

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Hypertriglyceridemia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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DHA-O

Group Type EXPERIMENTAL

DHA-O

Intervention Type DIETARY_SUPPLEMENT

Fish oil

Group Type ACTIVE_COMPARATOR

Fish oil

Intervention Type DIETARY_SUPPLEMENT

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Interventions

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DHA-O

Intervention Type DIETARY_SUPPLEMENT

Fish oil

Intervention Type DIETARY_SUPPLEMENT

Placebo

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

* ages 18-79
* fasting TG levels, 150-499 mg/dL
* baseline DHA intake \<200mg/d
* active and in good health

Exclusion Criteria

* recent diagnosis of CHD or history of revascularization within 6mos of study
* use of lipid altering medications (other than stable statins)
* use of anticoagulants
* use of omega-3 products within 4 weeks of screening
* serum AST/ALT \>1.5x ULN and/or creatinine \>1.5 mg/dL at screening
* lipid altering foods or supplements
* women who are pregnant or of childbearing potential not using adequate birth control
* current use or history of drug or alcohol abuse
* inability to swallow capsules
Minimum Eligible Age

18 Years

Maximum Eligible Age

79 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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DSM Nutritional Products, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Kevin Maki, PhD

Role: PRINCIPAL_INVESTIGATOR

Biofortis Clinical Research, Inc.

Locations

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Biofortis Clinical Research

Addison, Illinois, United States

Site Status

Countries

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United States

References

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Maki KC, Yurko-Mauro K, Dicklin MR, Schild AL, Geohas JG. A new, microalgal DHA- and EPA-containing oil lowers triacylglycerols in adults with mild-to-moderate hypertriglyceridemia. Prostaglandins Leukot Essent Fatty Acids. 2014 Oct;91(4):141-8. doi: 10.1016/j.plefa.2014.07.012. Epub 2014 Jul 22.

Reference Type DERIVED
PMID: 25123060 (View on PubMed)

Other Identifiers

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2012-1048

Identifier Type: -

Identifier Source: org_study_id

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