Efficacy and Safety of Omega-3 Fatty Acids(Omacor®) for the Treatment of Immunoglobulin A Nephropathy

NCT ID: NCT00549692

Last Updated: 2012-09-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE3

Total Enrollment

152 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-11-30

Study Completion Date

2012-09-30

Brief Summary

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The purpose of this study is to compare omega-3 fatty acids with placebo for efficacy in retardation of increase of serum creatinine(SCr) in IgA Nephropathy

Detailed Description

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In the current clinical study, attempts are made to assess the safety and efficacy of omega-3 fatty acids by comparing between omega-3 fatty acids and the placebo in Korean patients with IgA nephropathy.

Conditions

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IgA Nephropathy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Omacor

Group Type EXPERIMENTAL

Omega-3 fatty acid ethylester90

Intervention Type DRUG

Dosage form :1g soft capsule Dosage : two capsules, twice a day.

Placebo Omacor

Group Type PLACEBO_COMPARATOR

Omega-3 fatty acid ethylester90

Intervention Type DRUG

Dosage form :1g soft capsule Dosage : two capsules, twice a day.

Interventions

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Omega-3 fatty acid ethylester90

Dosage form :1g soft capsule Dosage : two capsules, twice a day.

Intervention Type DRUG

Other Intervention Names

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Omacor®

Eligibility Criteria

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Inclusion Criteria

* Patient of both sexes age 18 or above
* Biopsy-proven IgA nephropathy
* Baseline serum creatinine ≥ 1.2mg/dl(Female),≥ 1.4mg/dl(Male)
* Able to give written informed consent

Exclusion Criteria

* Hypertension SBP\>160mmHg and/or DBP\>100mmHg
* Subject, who in the investigator's opinion, has a systemic disease that would contraindicate participation in this study
* Use of omega-3 fatty acids or analog supplement
* Pregnancy or breast feeding at time of entry or unwillingness to comply with measures for contraception
* Current or recent (within 30 days) exposure to any investigational drug
* Subject who has hypersensitivity to this agent as a previous illness
* Low platelet(\<100,000/㎕) or the subject who has a high risk of bleeding
* Use of corticosteroid during the treatment period or less than 3 months prior to the screening
* Use of anticoagulant during the treatment period or within 1 month or 6 half lives prior to screening
* Subject who in the investigator's opinion, would be confronted with a difficulty
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Pronova BioPharma ASA

INDUSTRY

Sponsor Role collaborator

Kuhnil Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Suhnggwon Kim, Professor

Role: STUDY_CHAIR

Seoul National University Hospital

Byung-Joo Park, MD,PhD,FISPE

Role: PRINCIPAL_INVESTIGATOR

Seoul National University College of Medicine

Locations

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Seoul National University Bundang Hospital

Seongnam, Kyeonggi-do, South Korea

Site Status

Seoul National University Hospital

Seoul, , South Korea

Site Status

Kyhung Hee University medical center

Seoul, , South Korea

Site Status

Samsumg Medical Center

Seoul, , South Korea

Site Status

Kangnam St. May's Hospital

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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06-OM-8301

Identifier Type: -

Identifier Source: org_study_id