Influence of Proprioceptive Reweighting Ability on Lower-limb Biomechanics During Functional Tasks
NCT ID: NCT04736511
Last Updated: 2025-12-03
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.
COMPLETED
NA
41 participants
INTERVENTIONAL
2021-02-15
2021-04-16
Brief Summary
Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.
The ability to dynamically reweight proprioceptive signals according to postural conditions is crucial for balance control.
The aim of this study is therefore to investigate the influence of proprioceptive reweighting on biomechanical determinants of ACL loads during functional tasks and unplanned side cutting manoeuvers.
Related Clinical Trials
Explore similar clinical trials based on study characteristics and research focus.
Proprioceptive Isokinetic Repositioning, Functional Testing, and a Self-reported Questionnaire Before and After Anterior Cruciate Ligament Reconstruction
NCT04058574
Definition of Biomechanical Indices Measurable During Sport Movements for the Prevention of Primary and Secondary ACL Injury
NCT03840551
Investigation of the Effects of Proprioceptive Exercises After Anterior Cruciate Ligament Surgery
NCT07333092
Can Sensorimotor Function Predict Graft Rupture After ACL Reconstruction
NCT04162613
Relationship Between Proprioceptive Flexibility and the Occurrence of Lower Limb Ligament Injury in Pivot-contact Sports
NCT07028723
Detailed Description
Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.
Several anatomical, biomechanical and sensorimotor risk factors have been clearly identified, however the implication of the central nervous system was recently highlighted. Indeed, it has been shown that individuals who will suffer of ACL ruptures exhibited a decreased functional connectivity between brain regions responsible for postural control and sensorimotor processing. Due to the unanticipated situations that occurred during game situations, the role of the brain (i.e neural control) is now advocated to explain sensorimotor errors leading to injuries during complex tasks such as faking an opponent. Muscle vibration is a reliable tool to assess proprioceptive integration during postural control. The ability to shift from one proprioceptive cue to another when postural conditions are changing is crucial. This dynamic reweighting process allow to obtain an optimal postural control. However, recent investigations revealed that this process is altered among symptomatic populations, elderly patients or even under fatigue conditions. More precisely, some individuals seem able to shift proprioceptive reliance while other doesn't. To our knowledge, no studies have investigated the link between proprioceptive reweighting and biomechanical determinants of ACL loads during functional tasks. Thus, the aim of this study is to compare lower-limb biomechanics during unanticipated side cutting manoeuvres and single leg drop vertical jump among young handball players according to their ability to reweight proprioceptive signals.
Conditions
See the medical conditions and disease areas that this research is targeting or investigating.
Study Design
Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.
NA
SINGLE_GROUP
BASIC_SCIENCE
NONE
Study Groups
Review each arm or cohort in the study, along with the interventions and objectives associated with them.
Healthy volunteers
Handball players
Star Excursion Balance Test
The subject will be in unipodal support (only one foot on the ground) on the tested lower limb in the center of the platform. Three lines forming a "Y" will be arranged according to the lower limb in charge in three directions : anterior (ANT), posteromedial (PM) and posterolateral (PL). The goal is then to reach the longest distance possible in all three directions with the tip of the foot in relief before returning to the starting position. The subject will have 4 training trials per direction on each lower limb then 3 trials will be recorded in order to keep the average.
Single leg Drop Vertical Jump
The subject will drop from a step and land on one leg, then jump as high as possible and stabilize again on the same leg. The height of the step is 30 cm. The subject will perform 3 consecutive jumps in the strictest respect of the instructions: drop to the level of the mark on the ground and bounce as high as possible while spending a minimum of time on the ground. The subject must stabilize for 3 seconds during the second contact with the ground so that the instructions and measurements are reproducible.
Unplanned sidestep cutting manoeuvre
The objective is to create an unanticipated playing situation, close to the daily actions of the subjects in the practice of handball. The subject will make sidestep cutting manœuvre in front of an opponent simulated by a dummy used during usual training.
The subject will sprint in a straight line and then at the force platform will make a rapid change of direction on the side of his shooting arm or will continue his run in a straight line. A light signal randomly will indicate to the player the direction in which he must carry out his manoeuvre. A computer reconstruction of the kinematics and dynamics (knee moment) will be performed.
Tendon vibration
The subject will be asked to stand, motionless in bipodal (both feet on the ground) support on a stable and unstable ground (foam). A tendon vibration (80Hz) will be randomly applied to the subject in the Achilles tendons or paravertebral muscles. This vibration will cause an alteration of proprioceptive information in the vibrated area leading to a disruption of postural balance. Thus, according to the amount of displacement of the center of pressure (CoP), the proprioceptive weighting ratio (dRPW) is calculated to deduce therefrom the weight assigned by the CNS to the various proprioceptive inputs during the postural task.
Interventions
Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.
Star Excursion Balance Test
The subject will be in unipodal support (only one foot on the ground) on the tested lower limb in the center of the platform. Three lines forming a "Y" will be arranged according to the lower limb in charge in three directions : anterior (ANT), posteromedial (PM) and posterolateral (PL). The goal is then to reach the longest distance possible in all three directions with the tip of the foot in relief before returning to the starting position. The subject will have 4 training trials per direction on each lower limb then 3 trials will be recorded in order to keep the average.
Single leg Drop Vertical Jump
The subject will drop from a step and land on one leg, then jump as high as possible and stabilize again on the same leg. The height of the step is 30 cm. The subject will perform 3 consecutive jumps in the strictest respect of the instructions: drop to the level of the mark on the ground and bounce as high as possible while spending a minimum of time on the ground. The subject must stabilize for 3 seconds during the second contact with the ground so that the instructions and measurements are reproducible.
Unplanned sidestep cutting manoeuvre
The objective is to create an unanticipated playing situation, close to the daily actions of the subjects in the practice of handball. The subject will make sidestep cutting manœuvre in front of an opponent simulated by a dummy used during usual training.
The subject will sprint in a straight line and then at the force platform will make a rapid change of direction on the side of his shooting arm or will continue his run in a straight line. A light signal randomly will indicate to the player the direction in which he must carry out his manoeuvre. A computer reconstruction of the kinematics and dynamics (knee moment) will be performed.
Tendon vibration
The subject will be asked to stand, motionless in bipodal (both feet on the ground) support on a stable and unstable ground (foam). A tendon vibration (80Hz) will be randomly applied to the subject in the Achilles tendons or paravertebral muscles. This vibration will cause an alteration of proprioceptive information in the vibrated area leading to a disruption of postural balance. Thus, according to the amount of displacement of the center of pressure (CoP), the proprioceptive weighting ratio (dRPW) is calculated to deduce therefrom the weight assigned by the CNS to the various proprioceptive inputs during the postural task.
Other Intervention Names
Discover alternative or legacy names that may be used to describe the listed interventions across different sources.
Eligibility Criteria
Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.
Inclusion Criteria
* Intensive training handball practice for at least two years, mastering the technical gesture of unplanned sidestep cutting manoeuvre
* Training volume of 5 hours minimum per week
* Signature of the consent (participants and parents for minors)
Exclusion Criteria
* Unfit to consent or refusal to participate in the study
* Obvious standing balance disorder or disabling neurological pathology
* Pain of the musculoskeletal system (joint, tendon or muscle) permanent or during exercise
* Fatigue (evaluation using the Borg scale) during the clinical examination (\> 6) prior to performing the sporting gesture
* Known skin allergy to any adhesive product
15 Years
25 Years
ALL
Yes
Sponsors
Meet the organizations funding or collaborating on the study and learn about their roles.
University Hospital, Brest
OTHER
Responsible Party
Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.
Principal Investigators
Learn about the lead researchers overseeing the trial and their institutional affiliations.
Olivier REMY-NERIS
Role: PRINCIPAL_INVESTIGATOR
CHRU BREST
Locations
Explore where the study is taking place and check the recruitment status at each participating site.
CHRU Brest
Brest, France, France
Countries
Review the countries where the study has at least one active or historical site.
References
Explore related publications, articles, or registry entries linked to this study.
Decker MJ, Torry MR, Wyland DJ, Sterett WI, Richard Steadman J. Gender differences in lower extremity kinematics, kinetics and energy absorption during landing. Clin Biomech (Bristol). 2003 Aug;18(7):662-9. doi: 10.1016/s0268-0033(03)00090-1.
Brumagne S, Cordo P, Verschueren S. Proprioceptive weighting changes in persons with low back pain and elderly persons during upright standing. Neurosci Lett. 2004 Aug 5;366(1):63-6. doi: 10.1016/j.neulet.2004.05.013.
Kiers H, Brumagne S, van Dieen J, van der Wees P, Vanhees L. Ankle proprioception is not targeted by exercises on an unstable surface. Eur J Appl Physiol. 2012 Apr;112(4):1577-85. doi: 10.1007/s00421-011-2124-8. Epub 2011 Aug 21.
Brumagne S, Diers M, Danneels L, Moseley GL, Hodges PW. Neuroplasticity of Sensorimotor Control in Low Back Pain. J Orthop Sports Phys Ther. 2019 Jun;49(6):402-414. doi: 10.2519/jospt.2019.8489.
Brumagne S, Janssens L, Knapen S, Claeys K, Suuden-Johanson E. Persons with recurrent low back pain exhibit a rigid postural control strategy. Eur Spine J. 2008 Sep;17(9):1177-84. doi: 10.1007/s00586-008-0709-7. Epub 2008 Jul 2.
Lubetzky AV, McCoy SW, Price R, Kartin D. Response to Tendon Vibration Questions the Underlying Rationale of Proprioceptive Training. J Athl Train. 2017 Feb;52(2):97-107. doi: 10.4085/1062-6050-52.1.06. Epub 2017 Jan 26.
Claeys K, Dankaerts W, Janssens L, Pijnenburg M, Goossens N, Brumagne S. Young individuals with a more ankle-steered proprioceptive control strategy may develop mild non-specific low back pain. J Electromyogr Kinesiol. 2015 Apr;25(2):329-38. doi: 10.1016/j.jelekin.2014.10.013. Epub 2014 Oct 31.
Bonnet CT, Lepeut M. Proximal postural control mechanisms may be exaggeratedly adopted by individuals with peripheral deficiencies: a review. J Mot Behav. 2011;43(4):319-28. doi: 10.1080/00222895.2011.589415. Epub 2011 Jul 6.
van den Hoorn W, Kerr GK, van Dieen JH, Hodges PW. Center of Pressure Motion After Calf Vibration Is More Random in Fallers Than Non-fallers: Prospective Study of Older Individuals. Front Physiol. 2018 Mar 26;9:273. doi: 10.3389/fphys.2018.00273. eCollection 2018.
Peterka RJ. Sensorimotor integration in human postural control. J Neurophysiol. 2002 Sep;88(3):1097-118. doi: 10.1152/jn.2002.88.3.1097.
Picot B, Lempereur M, Morel B, Forestier N, Remy-Neris O. Lack of Proprioceptive Strategy Modulation Leads to At-Risk Biomechanics for Anterior Cruciate Ligament in Healthy Athletes. Med Sci Sports Exerc. 2024 May 1;56(5):942-952. doi: 10.1249/MSS.0000000000003378. Epub 2024 Jan 8.
Pappas E, Shiyko MP, Ford KR, Myer GD, Hewett TE. Biomechanical Deficit Profiles Associated with ACL Injury Risk in Female Athletes. Med Sci Sports Exerc. 2016 Jan;48(1):107-13. doi: 10.1249/MSS.0000000000000750.
Zazulak BT, Hewett TE, Reeves NP, Goldberg B, Cholewicki J. The effects of core proprioception on knee injury: a prospective biomechanical-epidemiological study. Am J Sports Med. 2007 Mar;35(3):368-73. doi: 10.1177/0363546506297909. Epub 2007 Jan 31.
Mancini GB, Friedman HZ, Hramiec JE, DeBoe SF. Relation between graded, subcritical impairments of coronary flow reserve and regional myocardial dysfunction induced by isoproterenol infusion in dogs. Am Heart J. 1987 Apr;113(4):906-16. doi: 10.1016/0002-8703(87)90051-2.
Strand T, Tvedte R, Engebretsen L, Tegnander A. [Anterior cruciate ligament injuries in handball playing. Mechanisms and incidence of injuries]. Tidsskr Nor Laegeforen. 1990 Jun 30;110(17):2222-5. Norwegian.
Majewski M, Susanne H, Klaus S. Epidemiology of athletic knee injuries: A 10-year study. Knee. 2006 Jun;13(3):184-8. doi: 10.1016/j.knee.2006.01.005. Epub 2006 Apr 17.
Giroto N, Hespanhol Junior LC, Gomes MR, Lopes AD. Incidence and risk factors of injuries in Brazilian elite handball players: A prospective cohort study. Scand J Med Sci Sports. 2017 Feb;27(2):195-202. doi: 10.1111/sms.12636. Epub 2015 Dec 10.
Olsen OE, Myklebust G, Engebretsen L, Bahr R. Injury mechanisms for anterior cruciate ligament injuries in team handball: a systematic video analysis. Am J Sports Med. 2004 Jun;32(4):1002-12. doi: 10.1177/0363546503261724.
Petersen W, Braun C, Bock W, Schmidt K, Weimann A, Drescher W, Eiling E, Stange R, Fuchs T, Hedderich J, Zantop T. A controlled prospective case control study of a prevention training program in female team handball players: the German experience. Arch Orthop Trauma Surg. 2005 Nov;125(9):614-21. doi: 10.1007/s00402-005-0793-7.
Boden BP, Torg JS, Knowles SB, Hewett TE. Video analysis of anterior cruciate ligament injury: abnormalities in hip and ankle kinematics. Am J Sports Med. 2009 Feb;37(2):252-9. doi: 10.1177/0363546508328107.
Koga H, Nakamae A, Shima Y, Iwasa J, Myklebust G, Engebretsen L, Bahr R, Krosshaug T. Mechanisms for noncontact anterior cruciate ligament injuries: knee joint kinematics in 10 injury situations from female team handball and basketball. Am J Sports Med. 2010 Nov;38(11):2218-25. doi: 10.1177/0363546510373570. Epub 2010 Jul 1.
Krosshaug T, Slauterbeck JR, Engebretsen L, Bahr R. Biomechanical analysis of anterior cruciate ligament injury mechanisms: three-dimensional motion reconstruction from video sequences. Scand J Med Sci Sports. 2007 Oct;17(5):508-19. doi: 10.1111/j.1600-0838.2006.00558.x. Epub 2006 Dec 20.
Prodromos CC, Han Y, Rogowski J, Joyce B, Shi K. A meta-analysis of the incidence of anterior cruciate ligament tears as a function of gender, sport, and a knee injury-reduction regimen. Arthroscopy. 2007 Dec;23(12):1320-1325.e6. doi: 10.1016/j.arthro.2007.07.003.
Rizzo M, Holler SB, Bassett FH 3rd. Comparison of males' and females' ratios of anterior-cruciate-ligament width to femoral-intercondylar-notch width: a cadaveric study. Am J Orthop (Belle Mead NJ). 2001 Aug;30(8):660-4.
Zeng C, Gao SG, Wei J, Yang TB, Cheng L, Luo W, Tu M, Xie Q, Hu Z, Liu PF, Li H, Yang T, Zhou B, Lei GH. The influence of the intercondylar notch dimensions on injury of the anterior cruciate ligament: a meta-analysis. Knee Surg Sports Traumatol Arthrosc. 2013 Apr;21(4):804-15. doi: 10.1007/s00167-012-2166-4. Epub 2012 Aug 15.
Chaudhari AM, Lindenfeld TN, Andriacchi TP, Hewett TE, Riccobene J, Myer GD, Noyes FR. Knee and hip loading patterns at different phases in the menstrual cycle: implications for the gender difference in anterior cruciate ligament injury rates. Am J Sports Med. 2007 May;35(5):793-800. doi: 10.1177/0363546506297537. Epub 2007 Feb 16.
Hewett TE, Zazulak BT, Myer GD. Effects of the menstrual cycle on anterior cruciate ligament injury risk: a systematic review. Am J Sports Med. 2007 Apr;35(4):659-68. doi: 10.1177/0363546506295699. Epub 2007 Feb 9.
Wojtys EM, Huston LJ, Boynton MD, Spindler KP, Lindenfeld TN. The effect of the menstrual cycle on anterior cruciate ligament injuries in women as determined by hormone levels. Am J Sports Med. 2002 Mar-Apr;30(2):182-8. doi: 10.1177/03635465020300020601.
Hewett TE, Webster KE, Hurd WJ. Systematic Selection of Key Logistic Regression Variables for Risk Prediction Analyses: A Five-Factor Maximum Model. Clin J Sport Med. 2019 Jan;29(1):78-85. doi: 10.1097/JSM.0000000000000486.
Arundale AJH, Bizzini M, Giordano A, Hewett TE, Logerstedt DS, Mandelbaum B, Scalzitti DA, Silvers-Granelli H, Snyder-Mackler L. Exercise-Based Knee and Anterior Cruciate Ligament Injury Prevention. J Orthop Sports Phys Ther. 2018 Sep;48(9):A1-A42. doi: 10.2519/jospt.2018.0303.
Taylor JB, Waxman JP, Richter SJ, Shultz SJ. Evaluation of the effectiveness of anterior cruciate ligament injury prevention programme training components: a systematic review and meta-analysis. Br J Sports Med. 2015 Jan;49(2):79-87. doi: 10.1136/bjsports-2013-092358. Epub 2013 Aug 6.
Yoo JH, Lim BO, Ha M, Lee SW, Oh SJ, Lee YS, Kim JG. A meta-analysis of the effect of neuromuscular training on the prevention of the anterior cruciate ligament injury in female athletes. Knee Surg Sports Traumatol Arthrosc. 2010 Jun;18(6):824-30. doi: 10.1007/s00167-009-0901-2. Epub 2009 Sep 4.
Grimm NL, Jacobs JC Jr, Kim J, Denney BS, Shea KG. Anterior Cruciate Ligament and Knee Injury Prevention Programs for Soccer Players: A Systematic Review and Meta-analysis. Am J Sports Med. 2015 Aug;43(8):2049-56. doi: 10.1177/0363546514556737. Epub 2014 Dec 1.
Stevenson JH, Beattie CS, Schwartz JB, Busconi BD. Assessing the effectiveness of neuromuscular training programs in reducing the incidence of anterior cruciate ligament injuries in female athletes: a systematic review. Am J Sports Med. 2015 Feb;43(2):482-90. doi: 10.1177/0363546514523388. Epub 2014 Feb 25.
Taylor JB, Ford KR, Schmitz RJ, Ross SE, Ackerman TA, Shultz SJ. Sport-specific biomechanical responses to an ACL injury prevention programme: A randomised controlled trial. J Sports Sci. 2018 Nov;36(21):2492-2501. doi: 10.1080/02640414.2018.1465723. Epub 2018 Apr 19.
Neto T, Sayer T, Theisen D, Mierau A. Functional Brain Plasticity Associated with ACL Injury: A Scoping Review of Current Evidence. Neural Plast. 2019 Dec 27;2019:3480512. doi: 10.1155/2019/3480512. eCollection 2019.
Shultz SJ, Schmitz RJ, Cameron KL, Ford KR, Grooms DR, Lepley LK, Myer GD, Pietrosimone B. Anterior Cruciate Ligament Research Retreat VIII Summary Statement: An Update on Injury Risk Identification and Prevention Across the Anterior Cruciate Ligament Injury Continuum, March 14-16, 2019, Greensboro, NC. J Athl Train. 2019 Sep;54(9):970-984. doi: 10.4085/1062-6050-54.084. Epub 2019 Aug 28. No abstract available.
Fox AS, Bonacci J, McLean SG, Spittle M, Saunders N. What is normal? Female lower limb kinematic profiles during athletic tasks used to examine anterior cruciate ligament injury risk: a systematic review. Sports Med. 2014 Jun;44(6):815-32. doi: 10.1007/s40279-014-0168-8.
Kristianslund E, Faul O, Bahr R, Myklebust G, Krosshaug T. Sidestep cutting technique and knee abduction loading: implications for ACL prevention exercises. Br J Sports Med. 2014 May;48(9):779-83. doi: 10.1136/bjsports-2012-091370. Epub 2012 Dec 20.
Hewett TE, Myer GD, Ford KR, Heidt RS Jr, Colosimo AJ, McLean SG, van den Bogert AJ, Paterno MV, Succop P. Biomechanical measures of neuromuscular control and valgus loading of the knee predict anterior cruciate ligament injury risk in female athletes: a prospective study. Am J Sports Med. 2005 Apr;33(4):492-501. doi: 10.1177/0363546504269591. Epub 2005 Feb 8.
Powers CM. The influence of abnormal hip mechanics on knee injury: a biomechanical perspective. J Orthop Sports Phys Ther. 2010 Feb;40(2):42-51. doi: 10.2519/jospt.2010.3337.
Dingenen B, Malfait B, Nijs S, Peers KH, Vereecken S, Verschueren SM, Staes FF. Can two-dimensional video analysis during single-leg drop vertical jumps help identify non-contact knee injury risk? A one-year prospective study. Clin Biomech (Bristol). 2015 Oct;30(8):781-7. doi: 10.1016/j.clinbiomech.2015.06.013. Epub 2015 Jun 26.
Numata H, Nakase J, Kitaoka K, Shima Y, Oshima T, Takata Y, Shimozaki K, Tsuchiya H. Two-dimensional motion analysis of dynamic knee valgus identifies female high school athletes at risk of non-contact anterior cruciate ligament injury. Knee Surg Sports Traumatol Arthrosc. 2018 Feb;26(2):442-447. doi: 10.1007/s00167-017-4681-9. Epub 2017 Aug 24.
Dempsey AR, Lloyd DG, Elliott BC, Steele JR, Munro BJ, Russo KA. The effect of technique change on knee loads during sidestep cutting. Med Sci Sports Exerc. 2007 Oct;39(10):1765-73. doi: 10.1249/mss.0b013e31812f56d1.
Sigward SM, Powers CM. Loading characteristics of females exhibiting excessive valgus moments during cutting. Clin Biomech (Bristol). 2007 Aug;22(7):827-33. doi: 10.1016/j.clinbiomech.2007.04.003. Epub 2007 May 24.
Hewett TE, Myer GD. The mechanistic connection between the trunk, hip, knee, and anterior cruciate ligament injury. Exerc Sport Sci Rev. 2011 Oct;39(4):161-6. doi: 10.1097/JES.0b013e3182297439.
Ford KR, Shapiro R, Myer GD, Van Den Bogert AJ, Hewett TE. Longitudinal sex differences during landing in knee abduction in young athletes. Med Sci Sports Exerc. 2010 Oct;42(10):1923-31. doi: 10.1249/MSS.0b013e3181dc99b1.
Pollard CD, Sigward SM, Powers CM. Limited hip and knee flexion during landing is associated with increased frontal plane knee motion and moments. Clin Biomech (Bristol). 2010 Feb;25(2):142-6. doi: 10.1016/j.clinbiomech.2009.10.005. Epub 2009 Nov 13.
Lawrence RK 3rd, Kernozek TW, Miller EJ, Torry MR, Reuteman P. Influences of hip external rotation strength on knee mechanics during single-leg drop landings in females. Clin Biomech (Bristol). 2008 Jul;23(6):806-13. doi: 10.1016/j.clinbiomech.2008.02.009. Epub 2008 Apr 18.
Nguyen AD, Taylor JB, Wimbish TG, Keith JL, Ford KR. Preferred Hip Strategy During Landing Reduces Knee Abduction Moment in Collegiate Female Soccer Players. J Sport Rehabil. 2018 May 1;27(3):213-217. doi: 10.1123/jsr.2016-0026. Epub 2018 Apr 23.
Sigward SM, Pollard CD, Havens KL, Powers CM. Influence of sex and maturation on knee mechanics during side-step cutting. Med Sci Sports Exerc. 2012 Aug;44(8):1497-503. doi: 10.1249/MSS.0b013e31824e8813.
Stearns KM, Keim RG, Powers CM. Influence of relative hip and knee extensor muscle strength on landing biomechanics. Med Sci Sports Exerc. 2013 May;45(5):935-41. doi: 10.1249/MSS.0b013e31827c0b94.
Zazulak BT, Hewett TE, Reeves NP, Goldberg B, Cholewicki J. Deficits in neuromuscular control of the trunk predict knee injury risk: a prospective biomechanical-epidemiologic study. Am J Sports Med. 2007 Jul;35(7):1123-30. doi: 10.1177/0363546507301585. Epub 2007 Apr 27.
Hewett TE, Ford KR, Xu YY, Khoury J, Myer GD. Utilization of ACL Injury Biomechanical and Neuromuscular Risk Profile Analysis to Determine the Effectiveness of Neuromuscular Training. Am J Sports Med. 2016 Dec;44(12):3146-3151. doi: 10.1177/0363546516656373. Epub 2016 Jul 29.
Griffin LY, Agel J, Albohm MJ, Arendt EA, Dick RW, Garrett WE, Garrick JG, Hewett TE, Huston L, Ireland ML, Johnson RJ, Kibler WB, Lephart S, Lewis JL, Lindenfeld TN, Mandelbaum BR, Marchak P, Teitz CC, Wojtys EM. Noncontact anterior cruciate ligament injuries: risk factors and prevention strategies. J Am Acad Orthop Surg. 2000 May-Jun;8(3):141-50. doi: 10.5435/00124635-200005000-00001.
Mendiguchia J, Ford KR, Quatman CE, Alentorn-Geli E, Hewett TE. Sex differences in proximal control of the knee joint. Sports Med. 2011 Jul 1;41(7):541-57. doi: 10.2165/11589140-000000000-00000.
Myer GD, Brent JL, Ford KR, Hewett TE. A pilot study to determine the effect of trunk and hip focused neuromuscular training on hip and knee isokinetic strength. Br J Sports Med. 2008 Jul;42(7):614-9. doi: 10.1136/bjsm.2007.046086. Epub 2008 Feb 28.
Bonnette S, Diekfuss JA, Grooms DR, Kiefer AW, Riley MA, Riehm C, Moore C, Barber Foss KD, DiCesare CA, Baumeister J, Myer GD. Electrocortical dynamics differentiate athletes exhibiting low- and high- ACL injury risk biomechanics. Psychophysiology. 2020 Apr;57(4):e13530. doi: 10.1111/psyp.13530. Epub 2020 Jan 20.
Swanik CB. Brains and Sprains: The Brain's Role in Noncontact Anterior Cruciate Ligament Injuries. J Athl Train. 2015 Oct;50(10):1100-2. doi: 10.4085/1062-6050-50.10.08. Epub 2015 Sep 4.
Grooms DR, Page SJ, Nichols-Larsen DS, Chaudhari AM, White SE, Onate JA. Neuroplasticity Associated With Anterior Cruciate Ligament Reconstruction. J Orthop Sports Phys Ther. 2017 Mar;47(3):180-189. doi: 10.2519/jospt.2017.7003. Epub 2016 Nov 5.
Needle AR, Lepley AS, Grooms DR. Central Nervous System Adaptation After Ligamentous Injury: a Summary of Theories, Evidence, and Clinical Interpretation. Sports Med. 2017 Jul;47(7):1271-1288. doi: 10.1007/s40279-016-0666-y.
Swanik CB, Covassin T, Stearne DJ, Schatz P. The relationship between neurocognitive function and noncontact anterior cruciate ligament injuries. Am J Sports Med. 2007 Jun;35(6):943-8. doi: 10.1177/0363546507299532. Epub 2007 Mar 16.
Grindstaff TL, Jackson KR, Garrison JC, Diduch DR, Ingersoll CD. Decreased quadriceps activation measured hours prior to a noncontact anterior cruciate ligament tear. J Orthop Sports Phys Ther. 2008 Aug;38(8):508-16. doi: 10.2519/jospt.2008.2761. Epub 2008 Aug 1.
Diekfuss JA, Grooms DR, Yuan W, Dudley J, Barber Foss KD, Thomas S, Ellis JD, Schneider DK, Leach J, Bonnette S, Myer GD. Does brain functional connectivity contribute to musculoskeletal injury? A preliminary prospective analysis of a neural biomarker of ACL injury risk. J Sci Med Sport. 2019 Feb;22(2):169-174. doi: 10.1016/j.jsams.2018.07.004. Epub 2018 Jul 10.
Diekfuss JA, Grooms DR, Nissen KS, Schneider DK, Foss KDB, Thomas S, Bonnette S, Dudley JA, Yuan W, Reddington DL, Ellis JD, Leach J, Gordon M, Lindsey C, Rushford K, Shafer C, Myer GD. Alterations in knee sensorimotor brain functional connectivity contributes to ACL injury in male high-school football players: a prospective neuroimaging analysis. Braz J Phys Ther. 2020 Sep-Oct;24(5):415-423. doi: 10.1016/j.bjpt.2019.07.004. Epub 2019 Jul 17.
Grooms DR, Page S, Onate JA. Brain Activation for Knee Movement Measured Days Before Second Anterior Cruciate Ligament Injury: Neuroimaging in Musculoskeletal Medicine. J Athl Train. 2015 Sep 29. doi: 10.4085/1062-6050-50-10-02. Online ahead of print.
Goossens N, Janssens L, Caeyenberghs K, Albouy G, Brumagne S. Differences in brain processing of proprioception related to postural control in patients with recurrent non-specific low back pain and healthy controls. Neuroimage Clin. 2019;23:101881. doi: 10.1016/j.nicl.2019.101881. Epub 2019 May 28.
Monjo F, Forestier N. Movement unpredictability and temporal constraints affect the integration of muscle fatigue information into forward models. Neuroscience. 2014 Sep 26;277:584-94. doi: 10.1016/j.neuroscience.2014.07.055. Epub 2014 Jul 30.
Peterka RJ. Sensory integration for human balance control. Handb Clin Neurol. 2018;159:27-42. doi: 10.1016/B978-0-444-63916-5.00002-1.
Vuillerme N, Danion F, Marin L, Boyadjian A, Prieur JM, Weise I, Nougier V. The effect of expertise in gymnastics on postural control. Neurosci Lett. 2001 May 4;303(2):83-6. doi: 10.1016/s0304-3940(01)01722-0.
Grooms DR, Onate JA. Neuroscience Application to Noncontact Anterior Cruciate Ligament Injury Prevention. Sports Health. 2016 Mar-Apr;8(2):149-52. doi: 10.1177/1941738115619164.
Koga H, Nakamae A, Shima Y, Bahr R, Krosshaug T. Hip and Ankle Kinematics in Noncontact Anterior Cruciate Ligament Injury Situations: Video Analysis Using Model-Based Image Matching. Am J Sports Med. 2018 Feb;46(2):333-340. doi: 10.1177/0363546517732750. Epub 2017 Oct 12.
Kiers H, Brumagne S, van Dieen J, Vanhees L. Test-retest reliability of muscle vibration effects on postural sway. Gait Posture. 2014;40(1):166-71. doi: 10.1016/j.gaitpost.2014.03.184. Epub 2014 Apr 3.
Eklund G. General features of vibration-induced effects on balance. Ups J Med Sci. 1972;77(2):112-24. doi: 10.1517/03009734000000016. No abstract available.
Roll JP, Vedel JP. Kinaesthetic role of muscle afferents in man, studied by tendon vibration and microneurography. Exp Brain Res. 1982;47(2):177-90. doi: 10.1007/BF00239377.
Claeys K, Brumagne S, Dankaerts W, Kiers H, Janssens L. Decreased variability in postural control strategies in young people with non-specific low back pain is associated with altered proprioceptive reweighting. Eur J Appl Physiol. 2011 Jan;111(1):115-23. doi: 10.1007/s00421-010-1637-x. Epub 2010 Sep 8.
Forestier N, Terrier R, Teasdale N. Ankle muscular proprioceptive signals' relevance for balance control on various support surfaces: an exploratory study. Am J Phys Med Rehabil. 2015 Jan;94(1):20-7. doi: 10.1097/PHM.0000000000000137.
Ivanenko YP, Talis VL, Kazennikov OV. Support stability influences postural responses to muscle vibration in humans. Eur J Neurosci. 1999 Feb;11(2):647-54. doi: 10.1046/j.1460-9568.1999.00471.x.
Related Links
Access external resources that provide additional context or updates about the study.
Laver L, Landreau P, Seil R, Popovic N, éditeurs. Handball Sports Medicine \[Internet\]. Berlin, Heidelberg: Springer Berlin Heidelberg; 2018
Laver L, Myklebust G. Handball Injuries: Epidemiology and Injury Characterization. In: Doral MN, Karlsson J, éditeurs. Sports Injuries: Prevention, Diagnosis, Treatment and Rehabilitation
Other Identifiers
Review additional registry numbers or institutional identifiers associated with this trial.
29BRC20.0288 NEURIBIO
Identifier Type: -
Identifier Source: org_study_id
More Related Trials
Additional clinical trials that may be relevant based on similarity analysis.