Can Sensorimotor Function Predict Graft Rupture After ACL Reconstruction
NCT ID: NCT04162613
Last Updated: 2024-01-10
Study Results
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Basic Information
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RECRUITING
200 participants
OBSERVATIONAL
2019-10-01
2026-12-31
Brief Summary
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Detailed Description
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Statistics Separate logistic regression models will be used to elucidate the influence of each muscle sensorimotor function variable on the outcomes (graft rupture, contra-lateral injury, return to sport/activity level failure), adjusted for potential confounders. With the LSI for the single-leg hop test as main outcome, power calculations show that with a re-injury rate of 7%, an estimated odds ratio of 0.95, power=80% and alpha=5 %, at least 174 individuals are needed. Based on this calculation, 200 individuals will be included for the prospective analysis, allowing for an approximate drop-out of 10%.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Patients with ACL reconstruction in Lund and Umeå
Persons who have suffered a unilateral anterior cruciate ligament injury treated with reconstruction
Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation
The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test.
At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.
Interventions
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Different measures of muscle function such as muscle strength, hop tests, postural orientation and muscle activation
The participants will be assessed with a physical test battery at baseline including: Isokinetic knee strength, Isometric strength of trunk and lower extremity, Single-leg hop for distance, side hop, postural orientation (single leg-squat, stair descending, forward lunge, Single-leg hop for distance, side-hop), hip and ankle range of joint motion, muscular activation pattern, 3D movement analysis and proprioception test.
At follow-up (2 years), the participants will be asked to answer a survey about new ACL injuries and return to sport/previous activity level.
Eligibility Criteria
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Inclusion Criteria
* With or without associated injuries to other structures of the knee (e.g., collateral ligament(s), meniscal injury)
* Age 15-35 years.
Exclusion Criteria
* Diseases or disorders overriding the knee condition (e.g., neurological or rheumatological disease)
* Not understanding the languages of interest (any Scandinavian language or English).
15 Years
35 Years
ALL
No
Sponsors
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Lund University
OTHER
Umeå University
OTHER
Responsible Party
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Principal Investigators
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Anna Cronström, PhD
Role: PRINCIPAL_INVESTIGATOR
Umeå University
Charlotte Häger, Professor
Role: STUDY_CHAIR
Umeå University
Locations
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UMotion laboratory
Umeå, , Sweden
Countries
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Central Contacts
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Facility Contacts
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References
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Cronstrom A, Ageberg E, Hager CK. Does sensorimotor function predict graft rupture, contra-lateral injury or failure to return to sports after ACL reconstruction? A protocol for the STOP Graft Rupture study. BMJ Open. 2021 Jan 8;11(1):e042031. doi: 10.1136/bmjopen-2020-042031.
Other Identifiers
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STOP Graft Rupture
Identifier Type: -
Identifier Source: org_study_id
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