Activation Failure of Knee Extensors After Anterior Cruciate Ligament Rupture Depending on the Contraction Mode

NCT ID: NCT06783062

Last Updated: 2025-01-20

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Total Enrollment: 60 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2025-02-28
• Study Completion Date: 2027-12-31

Brief Summary

The primary objective of the study is to evaluate the impact of ACL injury and ACL reconstruction on voluntary activation during maximal voluntary contraction (measured by neurophysiological parameters) according to the contraction mode.

The goal is to provide elements of knowledge to clinicians about the mechanisms of the activation failure depending on contraction mode, but also the resulting adapted clinical recommendations for conducting rehabilitation, and particularly for the use of different contraction modes.

The main hypothesis is that activation failure is not equal according to the contraction mode during maximal voluntary contractions and neurophysiological parameters will be decreased in comparison with non-injured subjects.

Secondary objectives are:

• To analyze the evolution of neurophysiological parameters between sessions interspaced by several months according to the contraction mode.
• To observe this time evolution depending on the treatment strategy chosen: rehabilitation or surgery plus rehabilitation.

Conditions

ACL - Anterior Cruciate Ligament Rupture; Activation Failure; Contraction Mode

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: PROSPECTIVE

Study Groups

Control

No interventions assigned to this group

ACL - rehabilitation

No interventions assigned to this group

ACL - surgery + rehabilitation

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

A. ACL-injured groups (surgically or conservatively treated):

1. Age between 18 and 50 years

2. Free, informed consent signed by the participant and the investigator.

3. Session 1: Delay of 2 to 6 weeks after injury, with a quiet knee (range of motion 110- 0°, minimal effusion, maximal contraction pain ≤ 2/10)

4. Session 2: Duration of 36 to 42 weeks after injury, with a quiet knee (range of motion 110-0°, minimal effusion, maximal contraction pain ≤ 2/10)

5. Independent person (Unprotected: under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision)

B. ControlGroup:

1. Age between 18 and 50 years

2. Free, informed consent signed by the participant and the investigator.

3. Sport practitioners: at least once per week practicing activities like collective sports, racket sports, combat sports, skiing, or on-loading activities with changing of directions.

4. Independent person (Unprotected: under guardianship, curatorship or other legal protection, deprived of liberty by judicial or administrative decision)

Exclusion Criteria

• 1. Subjects fitted with an implanted electronic device such as a cardiac pacemaker 2. Professional athlete 3. Pregnant women 4. Subject with systemic pathology or treatment affecting the musculoskeletal system 5. Subject with a history of neurological pathology or traumatic pathology, or pathology that required orthopedic treatment and/or surgery of the knee, hip and/or lumbar spine 6. Contraindication to isokinetic testing: incapacitating pain, evolving pathological process, non- healed fracture, unbalanced cardiovascular pathology (angina pectoris, arterial hypertension) 7. Contralateral knee injury 8. Subject inability to follow procedures or insufficient knowledge of project language 9. Data acquisition issue or injury during testing

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 50 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Toulouse NeuroImaging Center (ToNIC - UMR 1214 Inserm/UPS)

UNKNOWN

Sponsor Role: collaborator

La Tour Hospital

OTHER

Sponsor Role: lead

Responsible Party

Simon Barrué-Belou

Physiotherapist PhD., in charge of Biomechanics

Responsibility Role: PRINCIPAL_INVESTIGATOR

Central Contacts

Simon Barrué-Belou, PhD

Role: CONTACT

simon.barruebelou@latour.ch

+41 22 719 78 92

François Fourchet, PhD

Role: CONTACT

francois.fourchet@latour.ch

Other Identifiers

2024-01580

Identifier Type: -

Identifier Source: org_study_id