Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
288 participants
OBSERVATIONAL
2015-12-01
2021-12-30
Brief Summary
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Detailed Description
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Preliminary evidence suggest a possible relationship between Neutrophil-Lymphocyte Ratio (NLR) and Platelet-Lymphocyte Ratio (PLR) and perioperative neurocognitive disorders (NCD). We are going to investigate whether the values of NLR and PLR in patients undergoing elective non-cardiac surgery under general anesthesia, are related with increased risk of perioperative NCD.
Conditions
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Study Design
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COHORT
OTHER
Study Groups
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Noncardiac surgery
Calculation of the NLR and PLR in patients undergoing noncardiac surgery under general anesthesia
NLR
Calculation of NLR
PLR
Calculation of PLR
Interventions
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NLR
Calculation of NLR
PLR
Calculation of PLR
Eligibility Criteria
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Inclusion Criteria
* American Society of Anesthesiologists physical status I to III
* elective general, urological, gynecological and orthopedic surgery under general anesthesia
* native speakers of the Greek language
Exclusion Criteria
* had undergone surgery or anesthesia within the last 30 days
* had any prior or current history involving an affliction of the central nervous system
* were diagnosed with severe cognitive decline based on the 16 - item Informant Questionnaire on Cognitive Decline (IQCODE - 16)
* suffered from severe hearing or visual impairment
* any psychiatric disorder
* had a score \>5 in the Geriatric Depression Scale (GDS - 15)
* or a score in females \< 4 males \< 2 in the Lawton - Brody Instrumental Activities of Daily Living Scale (I.A.D.L.)
* reported alcohol consumption \> 35 units/week
* drug dependence
* had undergone previous neuropsychological testing
* Diabetes Mellitus type II with \> 10 years of diagnosis
* Diabetes Mellitus type I
* Hemoglobin A1c (HbA1c) \> 7.5%
* suffered from hemodynamical instability (\> 20% alterations of blood pressure perioperatively)
* or desaturation (one or more events of SpO2 \< 80% for more than 2 minutes) peri-operatively
* or blood loss of more than one unit
45 Years
80 Years
ALL
No
Sponsors
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University Hospital, Ioannina
OTHER
Larissa University Hospital
OTHER
University of Thessaly
OTHER
Responsible Party
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Elena Arnaoutoglou
Professor of Anesthesiology
Principal Investigators
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Eleni Arnaoutoglou, MD, PhD
Role: STUDY_CHAIR
Professor of Anesthesiology
Maria Ntalouka, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Consultant of Anesthesiology
Locations
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University of Thessaly
Larissa, , Greece
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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NLR, PLR and NCD
Identifier Type: -
Identifier Source: org_study_id
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