Differential Target Multiplexed Spinal Cord Stimulation (DTM-SCS®) Real World Outcomes

NCT ID: NCT04725838

Last Updated: 2024-08-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

255 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-01-29

Study Completion Date

2023-07-01

Brief Summary

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The UPGRADE registry will capture long-term, real-world outcomes to understand the effect of Differential Target Multiplexed (DTM®) programming in the Spinal Cord Stimulation (SCS) implanted population on the management of chronic pain, primarily on its use for trunk and/or limb pain. The clinical study is sponsored by Celéri Health and is funded through a financial grant from Medtronic's External Research Program. The registry study will be conducted across approximately 25 centers in the United States with up to 600 participants enrolled.

Detailed Description

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This clinical investigation is a prospective, observational, open-label, non-randomized, multi-center study. It is designed to collect clinical follow-up data on Differential Target Multiplexed (DTM®) programming that is available in Medtronic's Intellis™ and Vanta™ spinal cord stimulators, which has shown superiority to conventional programming parameters in a randomized controlled trial (NCT03606187).

Participants currently implanted with a permanent neurostimulation system, whom are planned for conversion to DTM® programming as well as newly identified participants planned to undergo a trial of neurostimulation using DTM® will be eligible to participate in this study. Data will be collected at baseline prior to DTM® programming exposure.

Participants who continue to meet eligibility criteria and have had their implanted DTM programming activated will enter a follow-up period for up to 24 months, where participant self-reported questionnaires will be assessed each month with study visits to occur at months 12 and 24.

Throughout the study, objective functional data will be collected automatically as part of the Medtronic device interrogation.

Conditions

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Chronic Pain

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Interventions

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Medtronic Intellis™ and Vanta™

Differential Target Multiplexed (DTM®) programming using Medtronic's Intellis™ or Vanta™ Spinal Cord Stimulation systems

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Participant must provide written informed consent prior to any clinical study-related procedure.
2. Participant is at least 18 years (or the minimum age required by local law to consent for participation in a clinical investigation) or older at the time of enrollment.
3. Participant has a permanent Medtronic Intellis™ neurostimulation system implanted or is planning to be implanted with a Medtronic Intellis™ or Vanta™ neurostimulation system.
4. Participant has access to an iPhone or Android capable device and/or computer with regular internet access for the purposes of electronically completing web-based participant self-reported questionnaires via SMS text or email.

Exclusion Criteria

1. Participant is unable to provide written informed consent or to comply with study-related requirements, procedures, and visits.
2. Participant is a profound responder for all pain areas to existing neurostimulation therapy (≥80% reported relief).
3. Participant is enrolled, or intends to participate, in a clinical drug and/or device study (investigational device, investigational drug, new indication for a device or drug, or additional testing beyond standard of care procedures) which could confound the results of this trial as determined by the investigator.
4. Presence of other anatomic or comorbid conditions, or other medical, social, or psychological conditions that, in the investigator's opinion, could limit the participant's ability to participate in the clinical investigation or to comply with follow-up requirements.
5. Participant is pregnant or nursing.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Medtronic

INDUSTRY

Sponsor Role collaborator

Celéri Health, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michael Fishman, MD

Role: STUDY_DIRECTOR

Chief Medical Officer

Locations

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Neuroversion

Anchorage, Alaska, United States

Site Status

Desert Sky Spine & Sports Medicine

Oro Valley, Arizona, United States

Site Status

Desert Sky Spine & Sports Medicine

Sierra Vista, Arizona, United States

Site Status

NuVation Pain Group - Buena Park

Buena Park, California, United States

Site Status

NuVation Pain Group - Los Angeles

Los Angeles, California, United States

Site Status

Spine and Sports Specialty Medical Group

Orange, California, United States

Site Status

Spine & Nerve Diagnostic Center - Roseville

Roseville, California, United States

Site Status

Florida Pain Medicine - Brandon

Brandon, Florida, United States

Site Status

Jax Spine & Pain Centers - Fleming Island

Fleming Island, Florida, United States

Site Status

Jax Spine & Pain Centers - UF North

Jacksonville, Florida, United States

Site Status

Jax Spine & Pain Centers - Jacksonville

Jacksonville, Florida, United States

Site Status

Florida Spine & Pain Specialists

Riverview, Florida, United States

Site Status

Jax Spine & Pain Centers -St. Augustine

Saint Augustine, Florida, United States

Site Status

Florida Pain Medicine - Wesley Chapel

Wesley Chapel, Florida, United States

Site Status

National Spine and Pain Centers - Winter Park, FL

Winter Park, Florida, United States

Site Status

Centurion Spine & Pain Centers (Jax Spine)

Waycross, Georgia, United States

Site Status

Millennium Pain Center (National Spine and Pain Centers - Bloomington, IL)

Bloomington, Illinois, United States

Site Status

National Spine and Pain Centers - National Harbor (Oxon Hill)

Oxon Hill, Maryland, United States

Site Status

National Spine and Pain Centers - Pikesville, MD

Pikesville, Maryland, United States

Site Status

Comprehensive and Interventional Pain Management

Henderson, Nevada, United States

Site Status

National Spine and Pain Centers - The Pain Management Center - Voorhees

Voorhees Township, New Jersey, United States

Site Status

Carolinas Research Institute - Mallard Creek

Charlotte, North Carolina, United States

Site Status

Carolinas Research Institute - Huntersville

Huntersville, North Carolina, United States

Site Status

Premier Pain Treatment Institute - Hillsboro

Hillsboro, Ohio, United States

Site Status

Premier Pain Treatment Institute - Loveland

Loveland, Ohio, United States

Site Status

Premier Pain Treatment Institute - Mt. Orab

Mount Orab, Ohio, United States

Site Status

Oklahoma Pain Physicians - Norman

Norman, Oklahoma, United States

Site Status

Oklahoma Pain Physicians - Oklahoma City

Oklahoma City, Oklahoma, United States

Site Status

Oklahoma Pain Physicians - Purcell

Purcell, Oklahoma, United States

Site Status

North Texas Orthopedics & Spine Center- Keller/Alliance

Fort Worth, Texas, United States

Site Status

North Texas Orthopedics & Spine Center - Grapevine

Grapevine, Texas, United States

Site Status

Precision Spine Care

Tyler, Texas, United States

Site Status

Valley Pain Consultants

Winchester, Virginia, United States

Site Status

Northwest Pain Care

Spokane, Washington, United States

Site Status

Countries

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United States

Related Links

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Other Identifiers

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UPGRADE

Identifier Type: -

Identifier Source: org_study_id

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