SCS Research Study

NCT ID: NCT03763708

Last Updated: 2024-12-31

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

NA

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-12

Study Completion Date

2023-01-13

Brief Summary

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To characterize the effects of stimulation parameters on pain relief and other cohort specific outcomes.

Detailed Description

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Conditions

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Limb Pain Trunk Pain

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Cohort 1: Low Energy - Continuous

Subjects will be programmed to a specific frequency with a long pulse width at various amplitudes

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 2: Interleaving

Determine effects of delivering ping pulses combined with governed pulses while using separate sets of electrodes

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 3: Cycling Evolve

Subjects will be programmed to high dose (HD) stimulation with various cycling parameters

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 4: Low Energy Cycling 1

Effects of decreased pulse widths with increased frequency - with and without cycling parameters

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 5: Low Energy Cycling 2

Effects of decreased pulse widths with increased frequency - with and without cycling parameters (different pulse widths and frequencies than Cohort 4)

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 6: Differential Targeted Multiplexed-Low Energy Spinal Cord Stimulation (DTM-LE SCS)

Effects of decreased frequency and therapy cycling parameters

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 7: Super Cycle

Effects of longer cycle duration

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 8: Differential Targeted Multiplexed (DTM) for Neuro Sense (NS)

Effects of integrating Neuro Sense into DTM programming

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Cohort 9: Diabetic Peripheral Neuropathy (DPN) Flow

Characteristics of vital signs in DPN participants

Group Type EXPERIMENTAL

Spinal Cord Stimulation

Intervention Type DEVICE

Programming

Interventions

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Spinal Cord Stimulation

Programming

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. 22 years of age or older
2. Implanted with a Medtronic rechargeable neurostimulation system, for a labeled indication, for at least 1 month and expected longevity of neurostimulator is at least 5 months
3. Willing and able to provide signed and dated informed consent
4. Capable of comprehending and consenting in English
5. Willing and able to comply with all study procedures, including diary completion, and visits
6. Able to differentiate between pain associated with the indication for SCS implant and other types of pain

Exclusion Criteria

1. Implanted with neurostimulation system for an off-label indication
2. Currently enrolled or planning to enroll in an interventional clinical study that could potentially confound the study results
3. If female, pregnant or is of child-bearing potential and unwilling to use a medically acceptable form of birth control during the study
4. Has untreated major psychiatric comorbidity
5. Has a non-rechargeable neurostimulator where the battery longevity is not able to be estimated with the battery longevity calculator
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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MedtronicNeuro

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Center for Pain and Supportive Care

Phoenix, Arizona, United States

Site Status

Goodman Campbell Brain and Spine

Carmel, Indiana, United States

Site Status

Drez One

Somerset, Kentucky, United States

Site Status

Twin Cities Pain Clinic

Edina, Minnesota, United States

Site Status

Regional Brain and Spine

Cape Girardeau, Missouri, United States

Site Status

Carolinas Research Institute

Huntersville, North Carolina, United States

Site Status

Center for Interventional Pain and Spine

Lancaster, Pennsylvania, United States

Site Status

Pain Diagnostics and Interventional Care

Sewickley, Pennsylvania, United States

Site Status

Northwest Pain Care

Spokane, Washington, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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MDT18036

Identifier Type: -

Identifier Source: org_study_id