Management of Acute Appendicitis at District General Hospital

NCT ID: NCT04707339

Last Updated: 2021-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

200 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-30

Study Completion Date

2021-01-30

Brief Summary

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The Investigators aim to assess;

1. whether the changes in managing patients during COVID has reduced the negative appendicectomy rate?
2. compare the difference in outcomes of conservatively and surgically managed Acute Appendicitis?
3. Whether there uniformity in prescribing postoperative antibiotics with resultant outcomes?
4. Whether the incidence of complicated appendicitis has increased?

Detailed Description

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As acute appendicitis is the most commonly managed emergency presentation for surgeons, the investigators aim to assess whether the changes in managing patients during COVID has reduced the negative appendicectomy rate, to compare the difference in outcomes of conservatively and surgically managed Acute Appendicitis? to assess whether there uniformity in prescribing postoperative antibiotics with resultant outcomes? to assess whether the incidence of complicated appendicitis has increased? This will be a single centre retrospective observational study. All the patients presenting in A\&E department with a diagnosis of acute appendicitis to be included. the only exclusion criteria are the age of participants for less than 5 years. The data will be analysed and calculated using SPSS version 23.

Conditions

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Appendicitis Acute Covid19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Acute Appendicitis pre-COVID management

Audit of Acute appendicitis management in 2017-18

Appendicectomy

Intervention Type PROCEDURE

Laparoscopic or Open Appendicectomy

Acute Appendicitis during COVID management

Audit of Acute appendicitis management in 2020

Appendicectomy

Intervention Type PROCEDURE

Laparoscopic or Open Appendicectomy

Interventions

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Appendicectomy

Laparoscopic or Open Appendicectomy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* All participants reporting in accident and emergency with a diagnosis of acute appendicitis irrespective of age above 5 years, gender and morbidities (this group for conservative management)

Exclusion Criteria

* None
Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Princess Alexandra Hospital NHS Trust

OTHER

Sponsor Role lead

Responsible Party

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Naveed Kirmani

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Naveed Kirmani, FRCS

Role: PRINCIPAL_INVESTIGATOR

The Princess Alexandra Hospital NHS Trust

Locations

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The Princess Alexandra Hospital NHS Trust

Harlow, Essex, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Adeel A Dhahri, MRCS

Role: CONTACT

+447936636920

Naveed Kirmani, FRCS

Role: CONTACT

01279444455

Facility Contacts

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Adeel A Dhahri, MRCS

Role: primary

07936636920

Naveed Kirmani, FRCS

Role: backup

01279444455

References

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Hori T, Machimoto T, Kadokawa Y, Hata T, Ito T, Kato S, Yasukawa D, Aisu Y, Kimura Y, Sasaki M, Takamatsu Y, Kitano T, Hisamori S, Yoshimura T. Laparoscopic appendectomy for acute appendicitis: How to discourage surgeons using inadequate therapy. World J Gastroenterol. 2017 Aug 28;23(32):5849-5859. doi: 10.3748/wjg.v23.i32.5849.

Reference Type BACKGROUND
PMID: 28932077 (View on PubMed)

van den Boom AL, de Wijkerslooth EML, van Rosmalen J, Beverdam FH, Boerma EG, Boermeester MA, Bosmans JWAM, Burghgraef TA, Consten ECJ, Dawson I, Dekker JWT, Emous M, van Geloven AAW, Go PMNYH, Heijnen LA, Huisman SA, Jean Pierre D, de Jonge J, Kloeze JH, Koopmanschap MA, Langeveld HR, Luyer MDP, Melles DC, Mouton JW, van der Ploeg APT, Poelmann FB, Ponten JEH, van Rossem CC, Schreurs WH, Shapiro J, Steenvoorde P, Toorenvliet BR, Verhelst J, Versteegh HP, Wijnen RMH, Wijnhoven BPL. Two versus five days of antibiotics after appendectomy for complex acute appendicitis (APPIC): study protocol for a randomized controlled trial. Trials. 2018 May 2;19(1):263. doi: 10.1186/s13063-018-2629-0.

Reference Type BACKGROUND
PMID: 29720238 (View on PubMed)

Ferguson DM, Parker TD, Arshad SA, Garcia EI, Hebballi NB, Tsao K. Standardized Discharge Antibiotics May Reduce Readmissions in Pediatric Perforated Appendicitis. J Surg Res. 2020 Nov;255:388-395. doi: 10.1016/j.jss.2020.05.086. Epub 2020 Jun 29.

Reference Type BACKGROUND
PMID: 32615311 (View on PubMed)

Javanmard-Emamghissi H, Boyd-Carson H, Hollyman M, Doleman B, Adiamah A, Lund JN, Clifford R, Dickerson L, Richards S, Pearce L, Cornish J, Hare S, Lockwood S, Moug SJ, Tierney GM; COVID: HAREM (Had Appendicitis, Resolved/Recurred Emergency Morbidity/Mortality) Collaborators Group. The management of adult appendicitis during the COVID-19 pandemic: an interim analysis of a UK cohort study. Tech Coloproctol. 2021 Apr;25(4):401-411. doi: 10.1007/s10151-020-02297-4. Epub 2020 Jul 15.

Reference Type BACKGROUND
PMID: 32671661 (View on PubMed)

RIFT Study Group on behalf of the West Midlands Research Collaborative. Appendicitis risk prediction models in children presenting with right iliac fossa pain (RIFT study): a prospective, multicentre validation study. Lancet Child Adolesc Health. 2020 Apr;4(4):271-280. doi: 10.1016/S2352-4642(20)30006-7. Epub 2020 Feb 13.

Reference Type BACKGROUND
PMID: 32200936 (View on PubMed)

Other Identifiers

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3810

Identifier Type: -

Identifier Source: org_study_id

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