Social Cognition in Multiple Sclerosis, From a Study of Eye Movement and Gaze Strategies Using Video-oculography

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

76 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-05-23

Study Completion Date

2019-06-26

Brief Summary

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This study aims to:

* analyze prospectively the prevalence of subclinical oculomotor disorders (OMDs) in different phenotypes of Multiple Sclerosis (MS) and to study correlations with brain MRI T2 data.
* highlight link between modification of visual exploration strategies to decode emotions, and social behavioral disorders, in patients with demyelinating disease, from early to clinically definite stages.

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Detailed Description

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Conditions

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Multiple Sclerosis (MS) Multiple Sclerosis (MS) Relapsing Remitting Multiple Sclerosis (MS) Primary Progressive Multiple Sclerosis (MS) Secondary Progressive Radiologically Isolated Syndrome Clinically Isolated Syndrome Healthy

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Prospective, descriptive, comparative (case-control), monocentric study. Control are healthy volunteers. Pathological groups are Radiologically Isolated Syndrome (RIS), Clinically Isolated Syndrome (CIS), Relapsing-Remitting MS (RRMS), Secondary Progressive MS (SPMS) and Primary Progressive MS (PPMS).

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Radiologically Isolated Syndrome (RIS)

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Clinically Isolated Syndrome (CIS)

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Relapsing-Remitting MS (RRMS)

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Secondary Progressive MS (SPMS)

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Primary Progressive MS (PPMS)

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Healthy volunteer

Group Type EXPERIMENTAL

Video-oculography / Social cognition tasks / Neuropsychological evaluations

Intervention Type OTHER

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Interventions

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Video-oculography / Social cognition tasks / Neuropsychological evaluations

* Recording of eye movements with a video-oculography device during oculomotor paradigms (Fixations, horizontal and vertical reflex saccades, horizontal and vertical smooth pursuit, anti-saccades)
* Recording of eye gaze with a video-oculography device during emotions recognition tasks (Reading the Mind in the Eyes test (Baron-Cohen 2001); Ekman Faces task (1976))
* Neurological evaluation
* Neuropsychological evaluations
* Social cognitions tasks
* Behaviour assessment

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Male or Female.
* 18 years old and above.
* Sufficient written and oral expression in French.
* Covered by a health insurance system
* Written informed consent signed by the patient.
* For the MS group:

\* Patient diagnosed according to diagnostic criteria established by Polman et al. (2010): Radiologically Isolated Syndrome compatible with MS (RIS), Clinically Isolated Syndrome compatible with MS (CIS), Relapsing-Remitting MS, Secondary Progressive MS, or Primary Progressive MS.

\* Hospitalized or coming to perform a consultation.
* For the control group: No cognitive impairment (non pathological Mini-Mental State Examination (MMSE), according to age, gender and socio-cultural level).

Exclusion Criteria

* General anaesthesia within 3 months.
* Ophthalmological problems preventing a video-oculography examination.
* Oculomotor disorders:

* For the control group: "fixation disorders" or "ocular tracking disorders".
* For the MS group: atypical disorders.
* Cognitive disorders of the type: visual agnosia, visuo-spatial disorder, visuo-perceptual disorder or aphasia.
* Other neurological or ophthalmological disorders than MS
* History of stroke.
* Psychotropic drugs consummation.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes