Effect of Left Atrial Appendage Velocity on Left Atrial Structure and Function After Radiofrequency Ablation Combined With Left Atrial Appendage Occlusion

NCT ID: NCT04693871

Last Updated: 2021-03-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2021-01-01

Brief Summary

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Radiofrequency ablation of atrial fibrillation combined with left atrial appendage closure can not only improve symptoms in patients with non-valvular atrial fibrillation, but also prevent left atrial appendage thrombosis. The safety and effectiveness of left atrial appendage occlusion have been confirmed by randomized controlled trials and actual experience. Among patients with different left atrial appendage emptying speeds, there are limited studies on the structure and function of the left atrial appendage after LAA closure. In this study, patients with persistent nonvalvular atrial fibrillation were selected for radiofrequency ablation combined with LAA closure. The sinus rhythm was restored after the operation. According to the different emptying speed of the left atrial appendage, they were divided into a high-flow rate group and a low-flow rate group. The differences in the structure and function of the left atrium between the two groups were analyzed.

Detailed Description

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Conditions

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Left Atrial Appendage Velocity Left Atrial Structure Left Atrial Function

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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high-flow rate group

Transesophageal ultrasound

Intervention Type DEVICE

Patients with nonvalvular atrial fibrillation underwent radiofrequency ablation combined with left atrial appendage closure and recovered to sinus rhythm after the operation. To study the changes of left atrial organization and function of two groups of patients with different left atrial appendage emptying speeds.

low-flow rate group

Transesophageal ultrasound

Intervention Type DEVICE

Patients with nonvalvular atrial fibrillation underwent radiofrequency ablation combined with left atrial appendage closure and recovered to sinus rhythm after the operation. To study the changes of left atrial organization and function of two groups of patients with different left atrial appendage emptying speeds.

Interventions

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Transesophageal ultrasound

Patients with nonvalvular atrial fibrillation underwent radiofrequency ablation combined with left atrial appendage closure and recovered to sinus rhythm after the operation. To study the changes of left atrial organization and function of two groups of patients with different left atrial appendage emptying speeds.

Intervention Type DEVICE

Other Intervention Names

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Radiofrequency ablation of atrial fibrillation combined with left atrial appendage closure

Eligibility Criteria

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Inclusion Criteria

* Patients who received atrial fibrillation radiofrequency ablation combined with left atrial appendage closure.

Exclude Criteria

* Patients with incomplete data.
* Device embolism.
* Residual shunt around the device found by transesophageal echocardiography greater than 5 mm.
* Mitral valve stenosis.
* Artificial valve.
* Atrial septal defect.
* Dilated cardiomyopathy
* Moderate Severe mitral regurgitation
Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The Second Hospital of Hebei Medical University

OTHER

Sponsor Role lead

Responsible Party

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Ruiqin xie

Director of the Department of Cardiology in the Second Hospital of Hebei Medical University

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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The Second Hospital of Hebei Medical University

Shijiazhuang, Hebei, China

Site Status

Countries

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China

Other Identifiers

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XieRuiqinLAAEV

Identifier Type: -

Identifier Source: org_study_id

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