Additional Long-Term Follow-up for Subjects Implanted With a CyPass® Micro-Stent

NCT ID: NCT04629521

Last Updated: 2024-04-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

54 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-12-21

Study Completion Date

2023-04-05

Brief Summary

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The purpose of this study is to assess long-term (10 years post-CyPass implantation) status of the corneal endothelium in subjects who were implanted with the CyPass Micro-Stent in the COMPASS trial.

Detailed Description

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The COMPASS Trial (TMI-09-01/NCT01085357) was a prospective, randomized, comparative multicenter study to assess the safety and effectiveness of the CyPass Micro-Stent in subjects with primary open angle glaucoma who were undergoing cataract surgery. In the COMPASS Trial, 374 subjects undergoing cataract surgery were randomized to the CyPass group and received the CyPass Micro-Stent, whereas 131 subjects underwent cataract surgery alone. All subjects were to be followed for 2 years postoperatively. Four hundred eighty (480) subjects completed this study.

The COMPASS XT Trial (TMI-09-01E/GLD122b-C001/NCT02700984) was designed to collect safety data beyond 24 months postoperatively for subjects who completed the COMPASS Trial. In COMPASS-XT, clinical data was collected at 36 months, 48 months, and 60 months postoperatively for a total of 5-year follow-up across the 2 studies.

In this trial, COMPASS XXT, clinical data will be collected annually for the subjects who were implanted with the CyPass Micro-Stent in the COMPASS TRIAL until the subject reaches 10 years post-CyPass implantation. For some subjects, the first visit will be at or after 10 years post-CyPass implantation, and therefore the first visit may coincide with the Exit visit.

Conditions

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Primary Open Angle Glaucoma Cataract

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Cataract Surgery + CyPass

CyPass Micro-Stent implanted at the conclusion of cataract surgery (COMPASS trial)

Group Type EXPERIMENTAL

CyPass Micro-Stent

Intervention Type DEVICE

The CyPass Micro-Stent is a small tube with a through-lumen designed to redirect aqueous fluid from the front into the back of the eye. The device is implanted after completion of cataract surgery.

Cataract Surgery

Intervention Type PROCEDURE

Cataract surgery involves the removal of the natural lens, which has become clouded (called a cataract), and insertion of an artificial lens (called an intraocular lens). This procedure is done through a small surgical incision in the eye.

Interventions

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CyPass Micro-Stent

The CyPass Micro-Stent is a small tube with a through-lumen designed to redirect aqueous fluid from the front into the back of the eye. The device is implanted after completion of cataract surgery.

Intervention Type DEVICE

Cataract Surgery

Cataract surgery involves the removal of the natural lens, which has become clouded (called a cataract), and insertion of an artificial lens (called an intraocular lens). This procedure is done through a small surgical incision in the eye.

Intervention Type PROCEDURE

Other Intervention Names

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CyPass® Micro-Stent Model 241-S

Eligibility Criteria

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Inclusion Criteria

* Implantation with a CyPass Micro-Stent as a participant in the COMPASS trial (NCT01085357) (Transcend Medical, Incorporated, Study Number TMI-09-01).
* Able to understand the requirements of the study and willing to follow study instructions, provide written informed consent, and agree to comply with all study requirements, including the required study follow-up visits.

Exclusion Criteria

* Inability to comply with the protocol or required follow-up visit/procedures.
Minimum Eligible Age

45 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Clinical Operations Lead, Surgical

Role: STUDY_DIRECTOR

Alcon Research, LLC

Locations

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Eye Physicians and Surgeons of Arizona

Glendale, Arizona, United States

Site Status

Coastal Vision Medical Group

Orange, California, United States

Site Status

Eye Center of Northern Colorado, PC

Fort Collins, Colorado, United States

Site Status

Cape Coral Eye Center

Cape Coral, Florida, United States

Site Status

Jones Eye Center PC

Sioux City, Iowa, United States

Site Status

Ophthalmology Associates

St Louis, Missouri, United States

Site Status

Eye Associates and SurgiCenter of Vineland

Vineland, New Jersey, United States

Site Status

Cincinnati Eye Institute

Cincinnati, Ohio, United States

Site Status

Associates In Ophthalmology Ltd.

West Mifflin, Pennsylvania, United States

Site Status

University Eye Specialists

Maryville, Tennessee, United States

Site Status

The Vanderbilt Eye Institute

Nashville, Tennessee, United States

Site Status

Ophthalmology Associates

Fort Worth, Texas, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

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GLD122-P004

Identifier Type: -

Identifier Source: org_study_id

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