Post Approval Study of the AcrySof® IQ ReSTOR® Toric IOLs

NCT ID: NCT03733730

Last Updated: 2023-11-01

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

View full results

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

2449 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-11-27

Study Completion Date

2022-10-14

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This is a prospective, multicenter, post-approval active surveillance study. The purpose of this study is to report the rate of post-surgical intraocular inflammation (based upon a specified case definition) reported within a 180-day post-surgical period following attempted implantation of an ACRYSOF IQ RESTOR Toric or ACRYSOF IQ RESTOR IOL in the US.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

If a second eye will participate in the study, subjects will receive the second eye cataract surgery within 20 days of the first eye surgery. Four postoperative follow-up visits are planned to occur at 1-2 days, 7-14 days, 30-60 days, and 90-180 days, for each enrolled eye. Subject participation in this study is expected to last up to 7 months, including a total of 6 study visits for subjects implanted in one eye and up to 11 visits for subjects implanted in both eyes. Upon completion of the 180 days follow-up visit, subjects will be exited from the study.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Aphakia Presbyopia Astigmatism

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Arm 1 completed prior to the initiation of Arm 2. Within each arm, IOL assignment was parallel.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Cohort 1

ACRYSOF IQ RESTOR Multifocal Toric IOL (+3.0 D or +2.5 D) implanted in at least one eye during cataract surgery, with implantation occurring from November 2018 through July 2020.

Group Type EXPERIMENTAL

ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL

Intervention Type DEVICE

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision, reduction of residual cylinder and increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOL

Intervention Type DEVICE

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision, reduction of residual cylinder and increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

Cataract Surgery

Intervention Type PROCEDURE

Routine small incision cataract surgery with IOL implantation

Cohort 2

ACRYSOF IQ RESTOR +3.0 D Multifocal Toric IOL or ACRYSOF IQ RESTOR +2.5 D Multifocal IOL implanted in at least one eye during cataract surgery, with implantation occurring after July 2020.

Group Type EXPERIMENTAL

ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL

Intervention Type DEVICE

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision, reduction of residual cylinder and increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

ACRYSOF IQ RESTOR +2.5 D Multifocal IOL

Intervention Type DEVICE

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision with increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

Cataract Surgery

Intervention Type PROCEDURE

Routine small incision cataract surgery with IOL implantation

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

ACRYSOF IQ RESTOR +3.0 Multifocal Toric IOL

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision, reduction of residual cylinder and increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

Intervention Type DEVICE

ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOL

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision, reduction of residual cylinder and increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

Intervention Type DEVICE

ACRYSOF IQ RESTOR +2.5 D Multifocal IOL

Intraocular lens (IOL) intended for visual correction of aphakia in adult patients with and without presbyopia, who desire near, intermediate and distance vision with increased spectacle independence. IOLs are implantable medical devices and are intended for long term use over the lifetime of the cataract subject.

Intervention Type DEVICE

Cataract Surgery

Routine small incision cataract surgery with IOL implantation

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Models SND1T3, SND1T4, SND1T5, and SND1T6 Models SV25T3, SV25T4, SV25T5, and SV25T6 Model SV25T0

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Preoperative cataract in the study eye(s)
* Planned implantation in at least one eye with:

* Cohort 1: An ACRYSOF IQ RESTOR +3.0 D Multifocal Toric IOL (Models SND1T3, SND1T4, SND1T5 or SND1T6) or an ACRYSOF IQ RESTOR +2.5 D Multifocal Toric IOLs (Models SV25T3, SV25T4, SV25T5, and SV25T6) in accordance with the product labeling from November 2018 to July 2020
* Cohort 2: An ACRYSOF IQ RESTOR +3.0 D Multifocal Toric IOL (Models SND1T3, SND1T4, SND1T5 or SND1T6), or an ACRYSOF IQ RESTOR +2.5 D Multifocal IOL (Model SV25T0) in accordance with the product labeling after July 2020.
* Able to comprehend and sign a statement of informed consent
* Willing and able to complete all required postoperative visits

Exclusion Criteria

* Eyes with clinically significant ocular, including adnexa, or intraocular infection or inflammation (at the screening visit prior to surgery or on the day of surgery)
* History of any intraocular inflammation within the past 12 months (ex: uveitis, choroiditis)
* Combined procedures introducing an additional medical device during cataract surgery (ex: cataract surgery with implant of glaucoma stent)
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Responsibility Role SPONSOR

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Sr. Clinical Trial Lead, CRD Surgical

Role: STUDY_DIRECTOR

Alcon Research

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Trinity Research Group

Dothan, Alabama, United States

Site Status

Eye Doctors of Arizona

Phoenix, Arizona, United States

Site Status

InSight Vision Center

Fresno, California, United States

Site Status

Harvard Eye Associates

Laguna Hills, California, United States

Site Status

Wolstan Goldberg Eye Associates

Torrance, California, United States

Site Status

Eye Center of Northern Colorado, PC

Fort Collins, Colorado, United States

Site Status

Rand Eye Institute

Deerfield Beach, Florida, United States

Site Status

Central Florida Eye Specialists

DeLand, Florida, United States

Site Status

Mid Florida Eye Center

Mt. Dora, Florida, United States

Site Status

Newsom Eye and Laser Center

Sebring, Florida, United States

Site Status

SightTrust Eye Institute

Sunrise, Florida, United States

Site Status

Gainesville Eye Associates

Gainesville, Georgia, United States

Site Status

Sabates Eye Center

Leawood, Kansas, United States

Site Status

Durrie Vision

Overland Park, Kansas, United States

Site Status

Senior Health Services

Louisville, Kentucky, United States

Site Status

Willis-Knighton Eye Institute South

Shreveport, Louisiana, United States

Site Status

Chu Vision Institute

Bloomington, Minnesota, United States

Site Status

Associated Eye Care

Stillwater, Minnesota, United States

Site Status

Moyes Eye Center

Kansas City, Missouri, United States

Site Status

St. Louis Eye Institute

Town and Country, Missouri, United States

Site Status

Raymond Fong Eye Care

New York, New York, United States

Site Status

Seeta Eye Center

Poughkeepsie, New York, United States

Site Status

Carolina Eye Associates

Southern Pines, North Carolina, United States

Site Status

Bergstrom Eye Research

Fargo, North Dakota, United States

Site Status

Cincinnati Eye Institute

Cincinnati, Ohio, United States

Site Status

Vision for Life

Nashville, Tennessee, United States

Site Status

Kleinman Evangelista Eye Center of Texas

Arlington, Texas, United States

Site Status

Keystone Research

Austin, Texas, United States

Site Status

El Paso Eye Surgeons

El Paso, Texas, United States

Site Status

Chu Eye Institute

Fort Worth, Texas, United States

Site Status

Houston Eye Associates

Houston, Texas, United States

Site Status

Berkeley Eye Center

Houston, Texas, United States

Site Status

Baylor College of Medicine Alkek Eye Center

Houston, Texas, United States

Site Status

The Eye Institute of Utah

Salt Lake City, Utah, United States

Site Status

Piedmont Eye Center

Lynchburg, Virginia, United States

Site Status

Vistar Eye Center

Roanoke, Virginia, United States

Site Status

Northwest Eye Surgeons

Seattle, Washington, United States

Site Status

Centro Oftalmologico Metropolitano

San Juan, , Puerto Rico

Site Status

Countries

Review the countries where the study has at least one active or historical site.

United States Puerto Rico

Provided Documents

Download supplemental materials such as informed consent forms, study protocols, or participant manuals.

Document Type: Study Protocol

View Document

Document Type: Statistical Analysis Plan

View Document

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

P040020

Identifier Type: OTHER

Identifier Source: secondary_id

ILR431b-P001

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.