Visual Outcomes After Cataract Surgery: Multifocal AcrySof® IQ ReSTOR® Intraocular Lenses Versus Monofocal Intraocular Lenses

NCT ID: NCT01290068

Last Updated: 2018-07-02

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

208 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-04-30

Study Completion Date

2012-10-31

Brief Summary

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The purpose of this study is to assess and compare visual outcomes of the AcrySof® IQ ReSTOR® +3.0 D intraocular lens (IOL) to a commercially available monofocal IOL in cataract patients.

Detailed Description

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This study included subjects with bilateral age-related cataracts and either no preoperative corneal astigmatism, or preoperative regular corneal astigmatism confirmed by autokeratometry of ≤2.5 D.

Conditions

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Cataract

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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ReSTOR +3

AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL, bilateral implantation

Group Type EXPERIMENTAL

AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL

Intervention Type DEVICE

Multifocal IOL with extended secondary focal point implanted for long-term use over the lifetime of the cataract patient

ReSTOR +3 Toric

AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL, model determined by preoperative corneal astigmatism, bilateral implantation, or implanted in 1 eye with AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL in the other eye

Group Type EXPERIMENTAL

AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL

Intervention Type DEVICE

Multifocal IOL with extended secondary focal point implanted for long-term use over the lifetime of the cataract patient

AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL

Intervention Type DEVICE

Multifocal IOL with extended secondary focal point and astigmatism correction implanted for long-term use over the lifetime of the cataract patient

Monofocal

Monofocal IOL, bilateral implantation

Group Type ACTIVE_COMPARATOR

Monofocal IOL

Intervention Type DEVICE

Monofocal IOL implanted for long-term use over the lifetime of the cataract patient

Interventions

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AcrySof® IQ ReSTOR® +3.0 D Multifocal IOL

Multifocal IOL with extended secondary focal point implanted for long-term use over the lifetime of the cataract patient

Intervention Type DEVICE

AcrySof® IQ ReSTOR® +3.0 D Multifocal Toric IOL

Multifocal IOL with extended secondary focal point and astigmatism correction implanted for long-term use over the lifetime of the cataract patient

Intervention Type DEVICE

Monofocal IOL

Monofocal IOL implanted for long-term use over the lifetime of the cataract patient

Intervention Type DEVICE

Other Intervention Names

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SN6AD1 SND1T2, SND1T3, SND1T4, SND1T5

Eligibility Criteria

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Inclusion Criteria

* Willing and able to understand and sign an Informed Consent;
* Willing and able to attend post-operative examinations as per protocol schedule;
* Diagnosis of bilateral, age-related cataracts;
* Planned cataract removal via phacoemulsification with implantation of an IOL;
* Available to undergo second eye surgery within 6 weeks of the first eye surgery;
* Fulfill the recommendations of the "Warnings" and "Precautions" sections of the AcrySof IQ ReSTOR IOL and Monofocal IOL package inserts;
* No preoperative corneal astigmatism or preoperative regular corneal astigmatism ≤2.5D;
* Qualify in both eyes for either AcrySof® IQ ReSTOR® IOL Model SN6AD1 or AcrySof® IQ ReSTOR® Toric IOL Models SND1T2 through SND1T5 as indicated by the AcrySof IQ ReSTOR Multifocal Toric web-based calculator;
* Able to read and understand one of the following languages: Dutch, French, German, Italian, Spanish, English or Catalan.

Exclusion Criteria

* Previous corneal surgery and/or reshaping;
* Any abnormality, disease and/or conditions of the cornea (ie, keratoconus, corneal dystrophy, severe keratitis, corneal scar, etc.), which would clinically contraindicate the implantation of a toric IOL;
* Planned multiple procedures during cataract/IOL implantation surgery;
* Planned limbal relaxing incisions, excimer laser treatment or similar procedures prior to or during the course of the study;
* Pregnant, lactating, or planning pregnancy during the course of study;
Minimum Eligible Age

21 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Alcon Research

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Brand Lead, Surgical, Global Medical Affairs

Role: STUDY_DIRECTOR

Alcon Research

Other Identifiers

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RDG-10-269

Identifier Type: -

Identifier Source: org_study_id

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