Defining the Neural Dynamics of Concept Retrieval Using Electrocorticography

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

4 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-08-02

Study Completion Date

2023-01-31

Brief Summary

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This study will look at the way activity within the brain changes over time while a person is trying to think about certain everyday concepts. To measure brain activity accurately, we will be using electrodes placed on people's brains during awake brain surgery.

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Detailed Description

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This study will measure the dynamics of cortical activity among early modal cortex and multimodal cortical regions during conceptual retrieval using electrocorticography. Participants will be patients undergoing awake temporal lobe craniotomies. During the surgery patients will have multiple high-density grids placed to simultaneously record activity in multiple areas while the patient is performing language tasks. Activity in each of these regions will be tested for timing differences and informational directionality to determine the temporal dynamics.

Conditions

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Aphasia

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Present a behavioral intervention to a single group of participants and measure subsequent electrical activity in the brain.

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Concept Retrieval

Patients will be given behavioral intervention, and their brain activity recorded.

Group Type EXPERIMENTAL

Concepts

Intervention Type BEHAVIORAL

Images and sounds that are characteristic of various common objects.

Interventions

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Concepts

Images and sounds that are characteristic of various common objects.

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Clinically determined to require an awake left temporal resection of a brain lesion with concurrent language testing.
* English as a first language.

Exclusion Criteria

* Significant preoperative neuropsychological deficits in memory or naming.
* Patients with inability to make decisions regarding their participation in this research project.
* Surgeon does not plan to expose the area of interest or determines that recording during the resection will interfere with his surgical plan.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No