Study of Electroencephalogram (EEG) Measurement During Different Stimulations of the Lower Urinary Tract

NCT ID: NCT01389921

Last Updated: 2019-07-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

83 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-02-28

Study Completion Date

2014-04-30

Brief Summary

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The purpose of this study is to investigate afferent and cortical activities during bladder filling under different stimulations of the lower urinary tract. The participants of the study are healthy test persons and patients with overactive bladder.

Detailed Description

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Conditions

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Healthy Nonneurogenic Neurogenic Bladder Dysfunction Neurogenic Bladder Dysfunction Nos

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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healthy testpersons

Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.

Group Type EXPERIMENTAL

Electroencephalography

Intervention Type OTHER

Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

patients with non-neurogenic OAB

Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome.

Group Type EXPERIMENTAL

Electroencephalography

Intervention Type OTHER

Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

patients with neurogenic OAB

Electroencephalography recording during electrical stimulation of different locations of the lower urinary tract as well as during electrical and heat stimulation at the tibial and pudendal nerve and S3 dermatome

Group Type OTHER

Electroencephalography

Intervention Type OTHER

Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

Interventions

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Electroencephalography

Standard electroencephalography investigation according to the ICS standard Current recording of latency and amplitude of evoked potentials

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Right-handed
* Written informed consent

Exclusion Criteria

* Any psychological diseases
* Any renal, cardiac, and pulmonary diseases
* Pregnancy or breastfeeding
* Problems keeping calm for 60 minutes in the sitting position
* Medication influencing EEG or bladder function
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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NCCR (National Center of Competence in Resaerch, Switzerland)

NETWORK

Sponsor Role collaborator

Ulrich Mehnert

OTHER

Sponsor Role lead

Responsible Party

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Ulrich Mehnert

Executive physician

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Ulrich Mehnert, Dr.

Role: PRINCIPAL_INVESTIGATOR

Neuro-Urology, Spinal Cord Injury Center & Research, University of Zürich, Balgrist University Hospital

Locations

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Spinal Cord Injury & Research, University of Zürich, Balgrist University Hospital

Zurich, , Switzerland

Site Status

Countries

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Switzerland

References

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Gregorini F, Knupfer SC, Liechti MD, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the bladder and urethra in middle-aged women: the effect of age. BJU Int. 2015 Apr;115 Suppl 6:18-25. doi: 10.1111/bju.13066.

Reference Type BACKGROUND
PMID: 25626360 (View on PubMed)

Knupfer SC, Liechti MD, Gregorini F, De Wachter S, Kessler TM, Mehnert U. Sensory function assessment of the human male lower urinary tract using current perception thresholds. Neurourol Urodyn. 2017 Feb;36(2):469-473. doi: 10.1002/nau.22956. Epub 2016 Jan 15.

Reference Type BACKGROUND
PMID: 26773330 (View on PubMed)

Gregorini F, Wollner J, Schubert M, Curt A, Kessler TM, Mehnert U. Sensory evoked potentials of the human lower urinary tract. J Urol. 2013 Jun;189(6):2179-85. doi: 10.1016/j.juro.2012.11.151. Epub 2012 Nov 30.

Reference Type BACKGROUND
PMID: 23206421 (View on PubMed)

Other Identifiers

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25/2009

Identifier Type: -

Identifier Source: org_study_id

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