Urine pH and Urinary Tract Infection

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-08-01

Study Completion Date

2021-12-13

Brief Summary

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Urinary tract infections (UTI) affect the urine pH and may lead to salt precipitation such as struvite. Bacteria with urease activity are known to alkalinise urine, but not much is known on how pH is changing over time during UTI.

This study aims at following urine pH progression at the time of diagnosis of UTI and during the treatment phase.

Description of the change in urine pH over time will help understanding the risk of struvite formation and potential timing of intervention.

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Detailed Description

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Adults presenting with UTI symptoms will be screened for infection and instructed to monitor urine pH during the course of treatment and 1 week after. Urine pH will be measured by the patients using calibrated pH-stix. Type of bacteria, antibiotics, and the type of diet will be monitored during the study.

Conditions

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Urinary Tract Infections Urinary Stone

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

PROSPECTIVE

Study Groups

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Cystitis

Patients with lower UTI will be included in this group

No interventions assigned to this group

Pyelonephritis

Patients with higher UTI will be included in this group

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Symptoms of dysuria, pollakiuria, no fever AND
* urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml)

Group 2. Pyelonephritis

* Unilateral flank pain, pollakiuria, dysuria, fever (\>38.5°C) AND
* urine-stix positive for leucocytes OR positive culture (\>10E5 cfu/ml)

Exclusion Criteria

* known urinary tract anatomic abnormalities
* Presence of a urine catheter
* Sepsis - septic shock
* Patient taking drug interfering with urine pH (diuretics, citrate, acetazolamide, topiramate,...)
* Patients with UTI diagnosed in the preceding month
* Patients having received antibiotics during the preceding month
* Male patient with a diagnosis of prostatitis
* Presence of infected kidney cyst
* Patient with diabetes
* Pregnant female
* Patient with obstructive pyelonephritis

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No