Analysis of SARS-CoV2 Urine Viral Particles and Association With Proximal Tubular Dysfunction

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

34 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-19

Study Completion Date

2022-07-01

Brief Summary

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The primary goal is to detect Severe Acute Respiratory Syndrome CoronaVirus 2 (SARS-CoV2) urine viral particles in patients in intensive care units, hospitalized for coronavirus Coronavirus Disease-19 (COVID-19) infection, and correlate the presence of the virus in the urine with proximal tubular dysfunction (defined by the association of at least 2 abnormalities: tubular proteinuria, renal phosphate leak, uricosuria, normoglycemic glycosuria, amino aciduria)

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Detailed Description

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Conditions

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SARS-CoV2 Infection Proximal Tubule Dysfunction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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RT-PCR SARS-COV2 in urine

proteinuria/renal phosphate leak/uricosuria/glycosuria/ aminoaciduria)

Intervention Type OTHER

Other Intervention Names

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Proximal tubular dysfunction testing

Eligibility Criteria

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Inclusion Criteria

* Person and / or trustworthy person who has received complete information on the organization of the research and who has not opposed their participation and the use of their data
* Hospitalized for ≥ 48 hours and ≤ 10 days
* SARS-CoV-2 positive nasopharyngeal sample
* Severity criteria: Lung involvement described as compatible with SARS-CoV-2 on radiography or scanner and partial pressure of oxygne (PaO2) / Fraction of inspired oxygen (FiO2) ≤ 300 mmHg and / or respiratory rate (RR) ≥ 30 / min

Exclusion Criteria

* Known chronic kidney disease, or initial Glomerular Filtration Rate (GFR) \<60 ml / min / 1.73m2 or Renal Transplant
* Known proteinuria
* Known proximal tubulopathy
* Treatment with Forxiga

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No