The Effect Of Transcranial Magnetic Stimulation In Patients With Stroke
NCT ID: NCT04562415
Last Updated: 2020-09-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
20 participants
INTERVENTIONAL
2018-10-01
2019-05-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
TRIPLE
Study Groups
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Active rTMS group
chronic ischemic stroke patients receiving active low frequency repetitive transcranial magnetic stimulation therapy and physical therapy
Active Repetitive Transcranial Magnetic Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and inhibitor rTMS was applied with a frequency of 1 Hz consisting of 1200 pulses for 20 minutes. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Active cTBS group
chronic ischemic stroke patients receiving active continuous theta burst stimulation therapy and physical therapy
Active Continuous Theta Burst Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and cTBS was administered for a total of 600 pulses consisting of 3 burst stimulations of 50 Hz repeated every 200 milliseconds for 40 seconds. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Sham cTBS group
chronic ischemic stroke patients receiving sham continuous theta burst stimulation therapy and physical therapy
Sham Continuous Theta Burst Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and sham cTBS was administered for a total of 600 pulses consisting of 3 burst stimulations of 50 Hz repeated every 200 milliseconds for 40 seconds. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Interventions
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Active Repetitive Transcranial Magnetic Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and inhibitor rTMS was applied with a frequency of 1 Hz consisting of 1200 pulses for 20 minutes. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Active Continuous Theta Burst Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and cTBS was administered for a total of 600 pulses consisting of 3 burst stimulations of 50 Hz repeated every 200 milliseconds for 40 seconds. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Sham Continuous Theta Burst Stimulation Therapy
10 sessions of intact hemispheric upper extremity motor area (M1) were targeted and sham cTBS was administered for a total of 600 pulses consisting of 3 burst stimulations of 50 Hz repeated every 200 milliseconds for 40 seconds. In addition, within 30 minutes after TMS sessions, all patients underwent 10 sessions of joint range of motion, stretching, strengthening, balance and coordination exercises, hand rehabilitation and daily living activities.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* aged between 18-80 years
* Mini mental test score ≥ 24
* upper limb Brunnstrom recovery stage 3 to 5
* upper extremity (elbow, wrist and finger) spasticity level Modified Ashworth Scale (MAS) 1+ to 3
Exclusion Criteria
* history of epilepsy
* a cardiac pacemaker
* pregnancy
* history of previous stroke or ischemic attack
* neurological diseases other than stroke
* metallic implant in brain or scalp (including cochlear implant)
* previous brain surgery
* orthopedic disease that prevents upper extremity movements
* poor general health (due to heart failure, chronic obstructive pulmonary disease, severe infection, etc.)
* diagnosis of malignancy
* injections of botulinum toxin in the last 6 months for the affected upper extremity
* drug or dosage changes of anti-spasticity medications in the last 1 month period
18 Years
80 Years
ALL
No
Sponsors
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Gaziler Physical Medicine and Rehabilitation Education and Research Hospital
OTHER
Responsible Party
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Yasin Demir
Clinical Associate Professor
Principal Investigators
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Bilge Yılmaz, Professor,MD
Role: STUDY_DIRECTOR
Gaziler PMR, Training and Research Hospital, Department of PMR
Ömer Kuzu, MD
Role: PRINCIPAL_INVESTIGATOR
Gaziler PMR, Training and Research Hospital, Department of PMR
Locations
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Gaziler PMR, Training and Research Hospital, Department of PMR
Ankara, Çankaya, Turkey (Türkiye)
Countries
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Other Identifiers
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5
Identifier Type: -
Identifier Source: org_study_id
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