Cryptic Bacteria of the Thyroid Tissue as a Possible Cause of the Pathology of This Organ
NCT ID: NCT04552496
Last Updated: 2020-09-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
120 participants
OBSERVATIONAL
2018-07-05
2022-09-01
Brief Summary
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The thyroid gland is an organ specifically exposed to the microbial environment due to its close location to the mouth microbiome. A number of bacterial phenotypes has been detected in the inflamed thyroid gland. A question raises as to whether bacteria have not already been present in the thyroid gland before the clinical symptoms of goiter became evident.
A problem in thyroid surgery, relatively uncommon but difficult for control, is prolonged thyroidectomy wound healing with skin flap, gland bed inflammation and fibrosis. The causative bacteria may belong to the strains persistently present in the thyroid gland parenchyma. Our objective is to answer questions: a) do the goiter tissue structures contain bacteria, b) if so, which bacterial phenotypes can be identified, c) what are the genetic similarities of the thyroid and periodontal bacterial strains.
Studies are carried out in patients with non-toxic multinodular goiter, toxic multinodular goiter, Graves' disease, single adenoma, Hashimoto's disease, thyroid cancer and recurrent thyroid disease. Tissue harvested during surgery is dissected immediately after thyroidectomy into fragments of parenchyma, arteries, veins and lymph nodes and cultured on Columbia blood agar base for up to 3 weeks. In this method bacteria present in the tissue grow in their natural environment, slowly proliferate and then form the on-plate colonies. It enables detection of even single bacteria usually difficult to be identified in planktonic media. Identification of the isolated bacteria is performed. Their DNA patterns are also compared.
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Detailed Description
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Conditions
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Study Design
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COHORT
RETROSPECTIVE
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* treated with antibiotics over the last 3 months
18 Years
80 Years
ALL
No
Sponsors
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Centre of Postgraduate Medical Education
OTHER
Responsible Party
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Sergiusz Durowicz
Principal Investigator
Principal Investigators
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Sergiusz Durowicz, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre of Postgraduate Medical Education, Warsaw, Poland
Marzanna Zaleska, PhD
Role: PRINCIPAL_INVESTIGATOR
Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
Waldemar L. Olszewski, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Central Clinical Hospital Ministry Interior Administration, Warsaw, Poland
Wiesław Tarnowski, Md, PhD
Role: PRINCIPAL_INVESTIGATOR
Centre of Postgraduate Medical Education, Warsaw, Poland
Ewa Swoboda-Kopeć, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
Medical University of Warsaw, Warsaw, Poland
Locations
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Department of General, Oncological and Gastrointestinal Surgery, Centre of Postgraduate Medical Education
Warsaw, , Poland
Department of Applied Physiology, Mossakowski Medical Research Centre, Polish Academy of Sciences
Warsaw, , Poland
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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85/PB/2018
Identifier Type: -
Identifier Source: org_study_id
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