Characterization of Myocardial Blood Flow During Heat Exposure

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

80 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-25

Study Completion Date

2023-03-31

Brief Summary

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The purpose of this study is to determine the increase in myocardial blood flow during heat exposure and how this response is affected by age and coronary artery disease.

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Detailed Description

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As a result of climate change, heat waves are more frequent and of longer duration. These heat waves are associated with a higher risk of hospitalization and mortality in vulnerable populations such as people with cardiovascular disease or cardiovascular risk factors. It has been hypothesized that this observation may be explained by the cardiovascular demands imposed by heat exposure.

Heat exposure requires increased cardiac work that may place individuals with cardiovascular disease at risk of ischemic events if the metabolic demand is not compensated by adequate blood supply. However, the extent to which cardiac work increases during heat exposure remains unknown. The aim of this study is to test the hypothesis that heat exposure increases myocardial blood flow and that this increase is affected by age and coronary artery disease.

Conditions

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Hot Weather; Adverse Effect Healthy Coronary Artery Disease Aging

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Passive heat exposure

Group Type EXPERIMENTAL

Heat exposure

Intervention Type OTHER

Participants will be exposed to heat exposure via a water-perfused suit to increase internal body temperature by 1.5 degrees Celsius.

Interventions

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Heat exposure

Participants will be exposed to heat exposure via a water-perfused suit to increase internal body temperature by 1.5 degrees Celsius.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age between 18-40 years or 60-80 years
* Non-smoker (≥1 year)
* Non-diabetic
* Normal kidney function
* Body Mass Index \<30 kg/m2
* Resting blood pressure \<140/\<90 mmHg
* Resting heart rate \<100 bpm

* Age between 60-80 years old
* History of angiographic coronary disease (≥70% arterial diameter narrowing of at least one major epicardial coronary artery) and/or prior coronary revascularization and/or documented prior acute coronary syndrome and/or perfusion defect during stress testing
* Stable medications (≥4 weeks) prior to enrollment

Exclusion Criteria

* Diagnosis of heart, vascular, respiratory, neurological or metabolic disease and/or a prescription of medication for the treatment of these diseases
* Pregnancy or lactation
* Dyslipidemia not controlled by medication

* Recent hospitalization (\<3 months) related to coronary artery disease
* Unstable angina (\<3 months)
* Recent coronary artery bypass surgery (\<3 months)
* Left branch block
* Ejection fraction \<40% and/or clinical signs of heart failure
* Severe valvular heart disease
* Hypertension not controlled by medication
* Diabetes not controlled by medication and/or serious complications related to diabetes

Minimum Eligible Age

18 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes