Breathing-Maneuver-Induced Myocardial Oxygenation Reserve Validated by FFR (B-MORE)
NCT ID: NCT04126148
Last Updated: 2024-10-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
350 participants
OBSERVATIONAL
2019-07-04
2024-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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OTHER
PROSPECTIVE
Study Groups
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Age matched Healthy participants (150)
Healthy Participants Age: \> 40y No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system
No interventions assigned to this group
Coronary Artery Disease (CAD) Patients (200)
Coronary Artery Disease (CAD) Patients Age \> 18 y Patients with an Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age: \> 40y
* No known current or pre-existing significant medical problems that would affect the cardiovascular or respiratory system.
CAD Patients
* Age \> 18 y
* Indication for invasive coronary angiography based on symptoms and a test positive for inducible coronary ischemia, or previous coronary angiography.
Exclusion Criteria
* General MRI contraindications: Pacemakers, defibrillating wires, implanted defibrillators, intracranial aneurysm clips, metallic foreign bodies in the eyes, knowledge or suspicion of pregnancy.
* Consumption of caffeine (coffee, tea, cocoa, chocolate, "energy drink") during the 12 hours prior to the exam.
* Regular nicotine consumption during the last 6 months.
Patients only
* Vasoactive medication (e.g. nitro) during the 12 hours prior to the exam Contraindications to adenosine (2nd or 3rd A-V block, sinus node disease, asthma, bronchoconstrictive diseases).
* Acute Coronary Syndrome (ACS), or previous Coronary Artery Bypass Surgery
* Previous myocardial infarction within 1 month
* Clinically unstable condition
* Significant or uncontrolled arrhythmia
18 Years
ALL
Yes
Sponsors
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McGill University Health Centre/Research Institute of the McGill University Health Centre
OTHER
Responsible Party
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Matthias Friedrich
Cardiologist
Principal Investigators
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Matthias G Friedrich, MD
Role: PRINCIPAL_INVESTIGATOR
Reseach Institute of the McGill University health Center
Locations
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McGill University Health Center
Montreal, Quebec, Canada
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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2019-4137
Identifier Type: -
Identifier Source: org_study_id
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