Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
75 participants
INTERVENTIONAL
2017-08-16
2020-09-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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NON_RANDOMIZED
PARALLEL
DIAGNOSTIC
NONE
Study Groups
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echocardiographic increase in left atrial pressure
stress CMR
additional stress CMR to the established clinical diagnostics
echocardiographic no increase in left atrial pressure
stress CMR
additional stress CMR to the established clinical diagnostics
Interventions
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stress CMR
additional stress CMR to the established clinical diagnostics
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* bronchial asthma (allergic)
* incompliant patient
* pacemaker, ICD, non MRI-capable devices
* inability to use the ergometer in the MRI
* haemodynamic relevant valvular heart disease
* pulmonary disease (vital capacity or forced expiratory flow \<80% of healthy control)
* angina pectoris
* post cardiac infarction
* anaemia (Hb \<12 g/dl)
* uncontrollable hypertension (\>150 mmHg systolic or \>100 mmHg diastolic)
* age \<18 years
* pregnancy
* claustrophobia
* renal insufficiency
* allergic to gadolinium based contrast agents
18 Years
ALL
No
Sponsors
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Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)
OTHER
University of Göttingen
OTHER
Responsible Party
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Andreas Schuster
PD Dr. med
Principal Investigators
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Andreas Schuster, MD, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Göttingen
Locations
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University Hospital Goettingen
Göttingen, , Germany
Countries
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References
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Backhaus SJ, Schulz A, Lange T, Rosel SF, Schmidt-Schweda LS, Kutty S, Kowallick JT, Treiber J, Rolf A, Sossalla S, Hasenfuss G, Schuster A. Insights from serial cardiovascular magnetic resonance imaging show early progress in diastolic dysfunction relates to impaired right ventricular deformation. Sci Rep. 2025 Feb 3;15(1):4090. doi: 10.1038/s41598-025-87032-5.
Schulz A, Schellinger IN, Backhaus SJ, Adler AS, Lange T, Evertz R, Kowallick JT, Hoffmann A, Matek C, Tsao PS, Hasenfuss G, Raaz U, Schuster A. Association of Cardiac MRI-derived Aortic Stiffness with Early Stages and Progression of Heart Failure with Preserved Ejection Fraction. Radiol Cardiothorac Imaging. 2024 Aug;6(4):e230344. doi: 10.1148/ryct.230344.
Backhaus SJ, Nasopoulou A, Lange T, Schulz A, Evertz R, Kowallick JT, Hasenfuss G, Lamata P, Schuster A. Left Atrial Roof Enlargement Is a Distinct Feature of Heart Failure With Preserved Ejection Fraction. Circ Cardiovasc Imaging. 2024 Jul;17(7):e016424. doi: 10.1161/CIRCIMAGING.123.016424. Epub 2024 Jul 16.
Backhaus SJ, Schulz A, Lange T, Evertz R, Kowallick JT, Hasenfuss G, Schuster A. Rest and exercise-stress estimated pulmonary capillary wedge pressure using real-time free-breathing cardiovascular magnetic resonance imaging. J Cardiovasc Magn Reson. 2024 Summer;26(1):101032. doi: 10.1016/j.jocmr.2024.101032. Epub 2024 Feb 29.
Backhaus SJ, Schulz A, Lange T, Schmidt-Schweda LS, Evertz R, Kowallick J, Hasenfuss G, Schuster A. Real-time cardiovascular magnetic resonance imaging for non-invasive characterisation of heart failure with preserved ejection fraction: final outcomes of the HFpEF stress trial. Clin Res Cardiol. 2024 Mar;113(3):496-508. doi: 10.1007/s00392-023-02363-5. Epub 2024 Jan 3.
Backhaus SJ, Lange T, Schulz A, Evertz R, Frey SM, Hasenfuss G, Schuster A. Cardiovascular magnetic resonance rest and exercise-stress left atrioventricular coupling index to detect diastolic dysfunction. Am J Physiol Heart Circ Physiol. 2023 May 1;324(5):H686-H695. doi: 10.1152/ajpheart.00081.2023. Epub 2023 Mar 10.
Schuster A, Schulz A, Lange T, Evertz R, Hartmann F, Kowallick JT, Hellenkamp K, Uecker M, Seidler T, Hasenfuss G, Backhaus SJ. Concomitant latent pulmonary vascular disease leads to impaired global cardiac performance in heart failure with preserved ejection fraction. Eur J Heart Fail. 2023 Mar;25(3):322-331. doi: 10.1002/ejhf.2781. Epub 2023 Mar 2.
Backhaus SJ, Uzun H, Rosel SF, Schulz A, Lange T, Crawley RJ, Evertz R, Hasenfuss G, Schuster A. Hemodynamic force assessment by cardiovascular magnetic resonance in HFpEF: A case-control substudy from the HFpEF stress trial. EBioMedicine. 2022 Dec;86:104334. doi: 10.1016/j.ebiom.2022.104334. Epub 2022 Nov 21.
Backhaus SJ, Lange T, George EF, Hellenkamp K, Gertz RJ, Billing M, Wachter R, Steinmetz M, Kutty S, Raaz U, Lotz J, Friede T, Uecker M, Hasenfuss G, Seidler T, Schuster A. Exercise Stress Real-Time Cardiac Magnetic Resonance Imaging for Noninvasive Characterization of Heart Failure With Preserved Ejection Fraction: The HFpEF-Stress Trial. Circulation. 2021 Apr 13;143(15):1484-1498. doi: 10.1161/CIRCULATIONAHA.120.051542. Epub 2021 Jan 21.
Other Identifiers
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35/8/15
Identifier Type: -
Identifier Source: org_study_id