Effects of Respiratory Muscle Exercises on Glucose Tolerance in Healthy Adults

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

42 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-20

Study Completion Date

2022-04-21

Brief Summary

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To evaluate the acute effects of respiratory muscle exercises vs. a control intervention on blood glucose kinetics in healthy adults after an oral glucose tolerance test.

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Detailed Description

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Conditions

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Healthy Aging Healthy Diet

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This study consists of four visits to the laboratory, each separated by at least 24 hours and each lasting approximately 2.5h. Total duration for each participant is approximately 2 weeks. The study is conducted in 40 healthy adults (≥ 18 years). The study is a randomized, controlled cross-over trial. We chose a cross-over design in order to test the effects of different respiratory exercises compared to a control intervention in order to minimize variability since each subject serves as his/her own control. Due to the nature of the intervention (respiratory muscle exercises), it is not possible to blind participants to the interventions.

Primary Study Purpose

OTHER

Blinding Strategy

NONE

Study Groups

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Respiratory Muscle Exercises

Two respiratory muscle exercises

Group Type EXPERIMENTAL

5min respiratory muscle exercises

Intervention Type OTHER

5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose

15min respiratory muscle exercises

Intervention Type OTHER

5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose

Control

The control intervention consists of quiet sitting for 15 min

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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5min respiratory muscle exercises

5 min of hyperpnea at a target intensity of 60-80% MVV 15-30min after ingestion of 75g of glucose

Intervention Type OTHER

15min respiratory muscle exercises

5 min of hyperpnea at a target intensity of 60-70% MVV 15-30min after ingestion of 75g of glucose

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years
* Healthy
* Non-smoking
* Body mass index (BMI): 18.5 - 29.9 kg∙m-2
* Normal lung function
* Willing to adhere to study rules

Exclusion Criteria

* Known or suspected non-compliance, drug or alcohol abuse
* Inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc. of the participant
* Previous enrolment into the current study
* Intake of medications affecting metabolism, the cardiovascular or the respiratory system, or sleep
* Acute illness or chronic conditions of the gastrointestinal tract, and health conditions affecting metabolism, the cardiovascular or the respiratory system, or sleep
* Pregnancy, breastfeeding, or intention to become pregnant during the study

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes