LDN and tDCS in Fibromyalgia

NCT ID: NCT04502251

Last Updated: 2020-08-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2/PHASE3

Total Enrollment

92 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-08-01

Study Completion Date

2020-07-01

Brief Summary

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Fibromyalgia is a complex generalized and diffuse musculoskeletal chronic pain; and pharmacological approaches are widely used to relieve pain and increase life quality. In this context, low-dose naltrexone (LDN) was able to increase nociceptive threshold in patients with fibromyalgia. Moreover, non-pharmacological techniques, like Transcranial Direct Current Stimulation (tDCS), have been shown effective for pain management. This study aims to evaluate the analgesic and neuromodulatory effect of combined LDN followed by tDCS in fibromyalgia patients. This is a randomized, double-blinded, parallel, placebo/sham-controlled trial, in which 92 (10% loss) women with fibromyalgia will be included included and signed the informed consent. Patients will be allocated into 4 groups: tDCS+LDN (n=21), Sham-tDCS+LDN (n=22), tDCS+Placebo (n=22), and Sham-tDCS+Placebo (n=21). LDN or placebo (p.o.) intervention lasts 26 days, in the last five, tDCS will be applied (sham or active, 20min, 2mA). Questionnaires assessed are: Sociodemographic, Visual Analog Pain Scale (VAS), Pain Catastrophizing Scale (PCS), State-Trait Anxiety Inventory (STAI), Fibromyalgia Impact Questionnaire (FIQ), Beck Depression Inventory (BDI-II), Chronic Pain Profile Scale (CPP). Also, pain measures were taken: Pain Pressure Threshold (PPT) and Conditioned Pain Modulation (CPM). Blood samples will be collected to analyze Brain Derived Neurotrophic Factor (BDNF) serum levels.

Detailed Description

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Conditions

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Fibromyalgia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

A randomized, double-blinded, parallel, controlled with placebo and sham stimulation, clinical trial.
Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
This is a double-blinded study, in which the participants and the outcomes assessor, who is the same as the investigator and the care provider, are blinded

Study Groups

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LDN + tDCS

Low Dose Naltrexone and Transcranial Direct Current Stimulation

Group Type ACTIVE_COMPARATOR

Low-Dose Naltrexone

Intervention Type DRUG

4.5mg daily dose, orally, during 26 days

Transcranial Direct Current Stimulation

Intervention Type DEVICE

An anodal electrode was placed on the scalp above the primary motor cortex (M1), contralateral to the dominant cortex. The cathodal electrode was placed on the supraorbital contralateral area. The current used was 2mA during 20 minutes.

LDN + Sham tDCS

Low Dose Naltrexone and Sham Transcranial Direct Current Stimulation

Group Type SHAM_COMPARATOR

Low-Dose Naltrexone

Intervention Type DRUG

4.5mg daily dose, orally, during 26 days

Sham Transcranial Direct Current Stimulation

Intervention Type DEVICE

Sham-tDCS stimulation consists of an active current during 30 seconds

Placebo + tDCS

Placebo and Transcranial Direct Current Stimulation

Group Type PLACEBO_COMPARATOR

Transcranial Direct Current Stimulation

Intervention Type DEVICE

An anodal electrode was placed on the scalp above the primary motor cortex (M1), contralateral to the dominant cortex. The cathodal electrode was placed on the supraorbital contralateral area. The current used was 2mA during 20 minutes.

Placebo

Intervention Type DRUG

The capsule presented the same format, size and color as LDN capsules, however the excipient used was starch.

Placebo + Sham tDCS

Placebo and Sham Transcranial Direct Current Stimulation

Group Type OTHER

Placebo

Intervention Type DRUG

The capsule presented the same format, size and color as LDN capsules, however the excipient used was starch.

Sham Transcranial Direct Current Stimulation

Intervention Type DEVICE

Sham-tDCS stimulation consists of an active current during 30 seconds

Interventions

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Low-Dose Naltrexone

4.5mg daily dose, orally, during 26 days

Intervention Type DRUG

Transcranial Direct Current Stimulation

An anodal electrode was placed on the scalp above the primary motor cortex (M1), contralateral to the dominant cortex. The cathodal electrode was placed on the supraorbital contralateral area. The current used was 2mA during 20 minutes.

Intervention Type DEVICE

Placebo

The capsule presented the same format, size and color as LDN capsules, however the excipient used was starch.

Intervention Type DRUG

Sham Transcranial Direct Current Stimulation

Sham-tDCS stimulation consists of an active current during 30 seconds

Intervention Type DEVICE

Other Intervention Names

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LDN tDCS Sham tDCS

Eligibility Criteria

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Inclusion Criteria

* signed the consent form
* women from 18 to 65 years
* confirmed diagnosis of fibromyalgia according 2016 American College of Rheumatology criteria
* read and write
* pain higher than 6 in the Visual Analogue Scale (VAS), in the last 3 months
* chronic stable treatment in the last 3 months.

Exclusion Criteria

* in use of opioid drugs;
* pregnancy or not using anticontraceptive
* history of alcohol or drug abuse in the last 6 months
* history of neurological pathologies
* history of arrhythmia
* history of use of drugs that might change vascular response
* history of head trauma
* history of neurosurgery
* decompensated systemic diseases or chronic inflammatory diseases (lupus, rheumatoid arthritis, Sjogren syndrome, Reiter syndrome)
* history of non-compensated hypothyroidism
* personal history of cancer.
Minimum Eligible Age

8 Years

Maximum Eligible Age

65 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Hospital de Clinicas de Porto Alegre

OTHER

Sponsor Role collaborator

Centro Universitario La Salle

OTHER

Sponsor Role lead

Responsible Party

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Andressa de Souza

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Universidade La Salle

Canoas, Rio Grande do Sul, Brazil

Site Status

Countries

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Brazil

References

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Provided Documents

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Document Type: Study Protocol, Statistical Analysis Plan, and Informed Consent Form

View Document

Other Identifiers

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70005317.5.0000.5307

Identifier Type: -

Identifier Source: org_study_id

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