European Study of Cerebral Aspergillosis Treated With Isavuconazole

NCT ID: NCT04486885

Last Updated: 2025-04-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

41 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-08-01

Study Completion Date

2023-03-01

Brief Summary

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Study clinical context Cerebral aspergillosis (CA) is a rare location of invasive aspergillosis (IA), associated with a high morbidity and mortality. Since 2002, voriconazole is the recommended first line treatment of invasive aspergillosis. More recently, isavuconazole appeared to be not less effective than voriconazole in the treatment of filamentous IFI, with a better tolerance profile.

The investigators aim to evaluate better the efficacy and the safety of isavuconazole in the treatment of cerebral aspergillosis by a descriptive, multicentric, international retrospective cohort study.

Detailed Description

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Conditions

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Cerebral Aspergillosis Invasive Aspergillosis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Proven or probable cerebral aspergillosis according to the EORTC criteria modified by adding diabetes in the host criteria
* In child or adult
* Treated by isavuconazole at least 7 days
* Diagnosed between March 2017 and June 2020

Exclusion Criteria

* Possible cerebral aspergillosis
* isavuconazole treatment for less than 7 days
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Imagine Institute

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Fanny Lanternier, MD

Role: PRINCIPAL_INVESTIGATOR

Hôpital Necker

Locations

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Hôpital Necker-Enfants Malades

Paris, , France

Site Status

Countries

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France

Other Identifiers

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hj-20-ESCAI

Identifier Type: -

Identifier Source: org_study_id

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