Echinocandins Versus Azoles for Candidemia Treatment

NCT ID: NCT03799172

Last Updated: 2020-03-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

79 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-11-01

Study Completion Date

2019-09-01

Brief Summary

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Candidemia is the most frequent invasive fungal disease in intensive care units (ICUs). It remains a major health concern, considering its attributable mortality up to 40% in critically ill patients. Successful clinical outcome requires early diagnosis and effective antifungal therapy. Guidelines for the treatment of candidemia were published by the Infectious Diseases Society of America (IDSA) and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID). According to these guidelines, echinocandins are the preferred first-line therapy for candidemia in critically ill patients. Considering the bibliography supporting this statement, the place of triazoles still needs to be defined in candidemia therapeutic arsenal. In this context, we are setting up a retrospective cohort study using Hospital database to compare the efficacy of echinocandins and azoles for the treatment of candidemia in intensive care units.

Detailed Description

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Conditions

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Candidemia

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Echinocandin group

Echinocandin group is the group of patients who received echinocandins as first-line therapy for candidemia

Echinocandin treatment

Intervention Type DRUG

Patients received echinocandins as a first-line therapy after candidemia diagnosis according to the standard of care

Triazole group

Triazole group is the group of patients who received triazoles as first-line therapy for candidemia

Triazole treatment

Intervention Type DRUG

Patients received triazoles as a first-line therapy after candidemia diagnosis according to the standard of care.

Candidemia was defined as at least one blood culture positive for Candida.

Interventions

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Echinocandin treatment

Patients received echinocandins as a first-line therapy after candidemia diagnosis according to the standard of care

Intervention Type DRUG

Triazole treatment

Patients received triazoles as a first-line therapy after candidemia diagnosis according to the standard of care.

Candidemia was defined as at least one blood culture positive for Candida.

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Patients who had a diagnosis of candidemia during ICU stay and were treated with echinocandins or azoles

Exclusion Criteria

* Patients with neutropenia
* Patients without antifungal treatment
* Patients who received antifungal therapy for more than two days before candidemia diagnosis
* Patients receiving liposomal amphotericin b or multiple antifungal agents as first-line therapy
* Patients who received less than 4 days of antifungal therapy after candidemia diagnosis
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hospices Civils de Lyon, Hôpital de la Croix-Rousse

Lyon, , France

Site Status

Countries

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France

Other Identifiers

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CRC_GHN_2019_001

Identifier Type: -

Identifier Source: org_study_id

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