Early Detection of Barrett's Esophagus Through Deep Image Retrieval

NCT ID: NCT04478929

Last Updated: 2020-07-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

300 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-08-31

Study Completion Date

2021-08-31

Brief Summary

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Barrett's oesophagus is a condition in which the area between the oesophagus and stomach no longer closes, allowing acidic contents of the stomach to enter the oesophagus and damage the lining. The project aims to assist clinicians by offering informed biopsy process, in which the system presents the operator with clinical outcomes of patients with visually similar GI tracts. The project goal is to assess the use of artificial intelligence-based similarity detection systems to better inform biopsy placement, increasing the reliability of bi-yearly inspections.

Detailed Description

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The project intention is to acquire secondary endoscopy captured data from clinicians to create a sufficient dataset to train a learning system to achieve the stated objective. The data required will feature footage (images/videos) from inside the oesophagus. The preferred data would contain associated diagnosis notes and description, however, data without diagnosis can still be used. All data can and will be anonymised, as personal information will not be useful in this work.

The data will be labelled by either researchers, or professional clinicians and prepared ready to feed into a chosen learning AI system. Through an iterative learning process, the chosen AI system will learn to discriminate between severity of Barrett's oesophagus and output optimal biopsy target.

Conditions

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Barrett Esophagus

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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gastroscopy clinic patients

NBT gastroscopy clinic invited participants. Patients are already due to attend the clinic, and we are inviting them to share their gastroscopy data with our research study.

Gastroscopy

Intervention Type DIAGNOSTIC_TEST

Routine gastroscopy

Interventions

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Gastroscopy

Routine gastroscopy

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Adult
* Attending Southmead Hospital for on OGD
* Has capacity
* Initially any indication, later patients with known Barrett's oesophagus

Exclusion Criteria

* Children (\<18)
* Patients without capacity
* Urgent and emergency procedures
* Limited English
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Cancer Research UK

OTHER

Sponsor Role collaborator

Leigh Taylor

OTHER

Sponsor Role lead

Responsible Party

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Leigh Taylor

Senior Research Officer

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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NBT, Southmead Hospital

Bristol, Avon, United Kingdom

Site Status

Countries

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United Kingdom

Central Contacts

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Lyndon Winstone, PhD

Role: CONTACT

+4411732 82009

benjamin winstone, PhD

Role: CONTACT

07890080486

Facility Contacts

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leonard griffiths

Role: primary

0117 414 6353 ext. 6353

Other Identifiers

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REDM0227_RP01

Identifier Type: -

Identifier Source: org_study_id

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