Raman Probe for In-vivo Diagnostics (During Oesophageal) Endoscopy
NCT ID: NCT03468634
Last Updated: 2024-04-25
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
25 participants
INTERVENTIONAL
2023-09-21
2024-04-23
Brief Summary
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Detailed Description
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A miniature probe has been developed that slides through a channel in the endoscope (telescope) to the surface of the oesophagus to make near instant assessments of its condition without the need for expensive and distressing tissue removal (biopsies). This project plans to move this technique from the laboratory to the clinic by demonstrating that the method is safe and reliable for use in real patients.
Conditions
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Study Design
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NON_RANDOMIZED
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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Adenocarcinoma
patients diagnosed with adenocarcinoma
endoscopy
Oesophageal endoscopy with biopsy
Squamous cell cancer
patients diagnosed with squamous cell cancer
endoscopy
Oesophageal endoscopy with biopsy
Other
patients diagnosed with another condition
endoscopy
Oesophageal endoscopy with biopsy
Barrett's oesophagus
patients diagnosed with Barrett's oesophagus
endoscopy
Oesophageal endoscopy with biopsy
Low-grade dysplasia
patients diagnosed with low-grade dysplasia
endoscopy
Oesophageal endoscopy with biopsy
High-grade dysplasia
patients diagnosed with high-grade dysplasia
endoscopy
Oesophageal endoscopy with biopsy
Indefinite for dysplasia
patients where the diagnosis is unclear
endoscopy
Oesophageal endoscopy with biopsy
no dysplasia
patients not diagnosed with any cancer
endoscopy
Oesophageal endoscopy with biopsy
Interventions
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endoscopy
Oesophageal endoscopy with biopsy
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
18 Years
ALL
Yes
Sponsors
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University of Bristol
OTHER
Gloucestershire Hospitals NHS Foundation Trust
OTHER
University of Exeter
OTHER
Responsible Party
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Principal Investigators
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Oliver Old, BMedSc MBChB
Role: PRINCIPAL_INVESTIGATOR
Gloucestershire Hospitals NHS Foundation Trust
Locations
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Gloucestershire Hospitals NHS Foundation Trust
Gloucester, Gloucestershire, United Kingdom
Countries
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References
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Isabelle M, Dorney J, Lewis A, Lloyd GR, Old O, Shepherd N, Rodriguez-Justo M, Barr H, Lau K, Bell I, Ohrel S, Thomas G, Stone N, Kendall C. Multi-centre Raman spectral mapping of oesophageal cancer tissues: a study to assess system transferability. Faraday Discuss. 2016 Jun 23;187:87-103. doi: 10.1039/c5fd00183h.
Kendall C, Stone N, Shepherd N, Geboes K, Warren B, Bennett R, Barr H. Raman spectroscopy, a potential tool for the objective identification and classification of neoplasia in Barrett's oesophagus. J Pathol. 2003 Aug;200(5):602-9. doi: 10.1002/path.1376.
Related Links
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RaPIDE project website
Other Identifiers
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II-LB-0315-20008
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
1516/017/162347
Identifier Type: -
Identifier Source: org_study_id
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