Prospective Comparison of Pull-PEG and Pull-PEG With Gastropexy

NCT ID: NCT04476498

Last Updated: 2023-07-13

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

122 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-07-15

Study Completion Date

2022-08-03

Brief Summary

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The study aims to compare the conventional pull-percutaneous endoscopic gastrostomy (pull-PEG) with a pull-PEG with gastropexy suture regarding the peristomal infection rate.

Detailed Description

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Pull-percutaneous endoscopic gastrostomy (Pull-PEG) is currently the standard technique for enteral nutrition in patients with swallowing disorders. Fistula and peristomal infection rates are one of the most common early complications which are caused by bacterial transmission through the oropharyngeal passage of the tube and by bacterial translocation out of the stomach into the abdominal wall. Retrospective data have shown that if pull-PEGs are attached with a gastropexy suture, the abdominal wall and stomach are fixed tightly and peristomal infection rates can be reduced significantly.

This randomised study wants to compare the peristomal infection rate of standard pull-PEGs and pull-PEGs with gastropexy suture. Peristomal infection rate is detected by classical inflammation rates including erythema, exsudates, and induration, development of pus, or focal peritonitis.

Conditions

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Peristomal Infection Rate Postinterventional Bleeding Postinterventional Mortality Rate

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

This study is a randomised prospective monocentric study with a one to one allocation in two different treatment arms.
Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants
The participants don't know which arm they were allocated to.

Study Groups

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Standard pull-PEG

Standard pull-PEG

In this group the participants receive a conventional pull-PEG as firstly described by Ponsky and Gauderer.

Group Type NO_INTERVENTION

No interventions assigned to this group

Pull-PEG with gastropexy

Pull-PEG with gastropexy

In this group the participants firstly receive a gastropexy with the Funada style gastropexy device. Afterwards a conventional pull-PEG will be inserted.

Group Type ACTIVE_COMPARATOR

Pull-PEG with Gastropexy

Intervention Type PROCEDURE

Additionally to a conventional pull-PEG a gastropexy will be performed.

Interventions

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Pull-PEG with Gastropexy

Additionally to a conventional pull-PEG a gastropexy will be performed.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 and over with an indication for a PEG-insertion

Exclusion Criteria

* ASA-classification \>4
* female patients who are pregnant or breast feeding
* existing contraindications for a PEG-implantation
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Johann Wolfgang Goethe University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Georg Dultz

Senior physician

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Mireen Friedrich-Rust, Professor

Role: STUDY_CHAIR

Johann Wolfgang Goethe University Hospital

Locations

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Klinikum der J. W. Goethe-Universität

Frankfurt am Main, Hesse, Germany

Site Status

Countries

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Germany

Other Identifiers

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JWGUHMED1-013

Identifier Type: -

Identifier Source: org_study_id

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