Late Phase II Study of TS-142 in Patients with Insomnia

NCT ID: NCT04469023

Last Updated: 2025-02-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE2

Total Enrollment

179 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-09

Study Completion Date

2021-11-16

Brief Summary

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This is a randomized, double-blind, multi-center, placebo-controlled, parallel-group exploratory study in patients with insomnia.

Detailed Description

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Conditions

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Patients with Insomnia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Caregivers Investigators

Study Groups

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TS-142 2.5 mg

Period in which participants received multiple-dose of 2.5 mg TS-142 prior to bedtime

Group Type EXPERIMENTAL

TS-142

Intervention Type DRUG

Participants received multiple-dose of 2.5, 5, 10 mg of TS-142 or placebo (oral tablet)

TS-142 5 mg

Period in which participants received multiple-dose of 5 mg TS-142 prior to bedtime

Group Type EXPERIMENTAL

TS-142

Intervention Type DRUG

Participants received multiple-dose of 2.5, 5, 10 mg of TS-142 or placebo (oral tablet)

TS-142 10 mg

Period in which participants received multiple-dose of 10 mg TS-142 prior to bedtime

Group Type EXPERIMENTAL

TS-142

Intervention Type DRUG

Participants received multiple-dose of 2.5, 5, 10 mg of TS-142 or placebo (oral tablet)

Placebo

Period in which participants received single placebo prior to bedtime

Group Type EXPERIMENTAL

TS-142

Intervention Type DRUG

Participants received multiple-dose of 2.5, 5, 10 mg of TS-142 or placebo (oral tablet)

Interventions

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TS-142

Participants received multiple-dose of 2.5, 5, 10 mg of TS-142 or placebo (oral tablet)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Japanese male and female age 20 years or older at the time of informed consent
* Outpatients
* Patients who meet the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria for insomnia disorder

Exclusion Criteria

* Patients who meet the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5) criteria excepting insomnia disorder preceding visit 1
* Patients who meet the DSM-5 criteria for Restless legs syndrome at visit 1
* Patients with comorbid psychiatric disorder(s), including depression, schizophrenia, anxiety
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Taisho Pharmaceutical Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Taisho Director

Role: STUDY_DIRECTOR

Taisho Pharmaceutical Co., Ltd.

Locations

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Taisho Pharmaceutical Co., Ltd selected site

Tokyo, , Japan

Site Status

Countries

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Japan

Other Identifiers

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TS142-203

Identifier Type: -

Identifier Source: org_study_id

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