A Long-Term Safety and Efficacy Study of Eszopiclone in Elderly With Primary Chronic Insomnia

NCT ID: NCT00386334

Last Updated: 2016-03-14

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

388 participants

Study Classification

INTERVENTIONAL

Study Start Date

2006-10-31

Study Completion Date

2008-02-29

Brief Summary

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To evaluate the long-term safety and efficacy of eszopiclone administered for 12 weeks in elderly subjects with primary chronic insomnia.Administration of eszopiclone 2 mg daily at bedtime for 12 weeks in elderly subjects with a diagnosis of primary chronic insomnia will be safe and well tolerated, improve subjective sleep measures, improve measures of Quality of Life and next day insomnia symptoms, and have no significant withdrawal central nervous system adverse events or rebound insomnia.

Detailed Description

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A double-blind, randomized, placebo controlled, parallel group study of eszopiclone in elderly subjects with primary chronic insomnia. The study will involve up to 9 visits and subject participation will be approximately 18 weeks. This study was previously posted by Sepracor Inc. In October 2009, Sepracor Inc. was acquired by Dainippon Sumitomo Pharma., and in October 2010, Sepracor Inc's name was changed to Sunovion Pharmaceuticals Inc.

Conditions

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Insomnia

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

TRIPLE

Participants Investigators Outcome Assessors

Study Groups

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Placebo

Week -2 to day 0 single blind one tablet placebo in the evening. Double blind period: Day 1 to Week 12 double blind one tablet placebo in the evening. Follow up period: two weeks (Weeks 13-14) single blind one tablet placebo in evening, and two weeks (Weeks 15-16) no drug washout.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Tablet one per day in the evening.

Eszopiclone

Week -2 to day 0 single blind one tablet placebo in evening. Double Blind period: Day 1 to Week 12 double blind one tablet 2 mg of eszopiclone in evening. Follow up period consists of two weeks (Weeks 13-14) single blind one tablet placebo in evening, and two weeks (Weeks 15-16) no drug washout.

Group Type EXPERIMENTAL

Eszopiclone

Intervention Type DRUG

2 mg tablet once per day in the evening

Placebo

Intervention Type DRUG

Tablet one per day in the evening.

Interventions

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Eszopiclone

2 mg tablet once per day in the evening

Intervention Type DRUG

Placebo

Tablet one per day in the evening.

Intervention Type DRUG

Other Intervention Names

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Lunesta

Eligibility Criteria

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Inclusion Criteria

* Male and female subjects with primary chronic insomnia. Subject is otherwise in good general health, based on screening physical examination and medical history.

Exclusion Criteria

* Subject has recent history of known clinically significant abnormal laboratory findings.
Minimum Eligible Age

65 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Sumitomo Pharma America, Inc.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director, CNS

Role: STUDY_CHAIR

Sumitomo Pharma America, Inc.

Locations

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Birmingham, Alabama, United States

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Chandler, Arizona, United States

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Glendale, Arizona, United States

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Tucson, Arizona, United States

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Anaheim, California, United States

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Irvine, California, United States

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La Mesa, California, United States

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Los Angeles, California, United States

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San Diego, California, United States

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San Diego, California, United States

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San Diego, California, United States

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Colorado Springs, Colorado, United States

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Denver, Colorado, United States

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Atlanta, Florida, United States

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Clearwater, Florida, United States

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Coral Springs, Florida, United States

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Delray Beach, Florida, United States

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Fort Myers, Florida, United States

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Gables, Florida, United States

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Jupiter, Florida, United States

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Maitland, Florida, United States

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Naples, Florida, United States

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Orlando, Florida, United States

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Pembroke Pines, Florida, United States

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Pinellas Park, Florida, United States

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Sarasota, Florida, United States

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St. Petersburg, Florida, United States

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St. Petersburg, Florida, United States

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Vero Beach, Florida, United States

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West Palm Beach, Florida, United States

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Stockbridge, Georgia, United States

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Honolulu, Hawaii, United States

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Chicago, Illinois, United States

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Chicago, Illinois, United States

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Vernon Hills, Illinois, United States

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Evansville, Indiana, United States

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Overland Park, Kansas, United States

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Prairie Village, Kansas, United States

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Crestview Hills, Kentucky, United States

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Lexington, Kentucky, United States

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Baton Rouge, Louisiana, United States

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Baltimore, Maryland, United States

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Boston, Massachusetts, United States

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Braintree, Massachusetts, United States

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Newton, Massachusetts, United States

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Florissant, Missouri, United States

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Hamilton, New Jersey, United States

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Albuquerque, New Mexico, United States

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Brooklyn, New York, United States

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Mineola, New York, United States

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New York, New York, United States

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New York, New York, United States

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Rochester, New York, United States

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Cary, North Carolina, United States

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Durham, North Carolina, United States

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Hickory, North Carolina, United States

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New Bern, North Carolina, United States

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Winston-Salem, North Carolina, United States

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Beachwood, Ohio, United States

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Cincinnati, Ohio, United States

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Cleveland, Ohio, United States

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Dayton, Ohio, United States

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Mogadore, Ohio, United States

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Oklahoma City, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Oklahoma City, Oklahoma, United States

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Allentown, Pennsylvania, United States

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Duncansville, Pennsylvania, United States

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Scotland, Pennsylvania, United States

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Warwick, Rhode Island, United States

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Anderson Pharmaceutical Research

Anderson, South Carolina, United States

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Anderson, South Carolina, United States

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Simpsonville, South Carolina, United States

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Dallas, Texas, United States

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Houston, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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San Antonio, Texas, United States

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Wichita Falls, Texas, United States

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Fairfax, Virginia, United States

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Richmond, Virginia, United States

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Spokane, Washington, United States

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Countries

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United States

References

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Ancoli-Israel S, Krystal AD, McCall WV, Schaefer K, Wilson A, Claus R, Rubens R, Roth T. A 12-week, randomized, double-blind, placebo-controlled study evaluating the effect of eszopiclone 2 mg on sleep/wake function in older adults with primary and comorbid insomnia. Sleep. 2010 Feb;33(2):225-34. doi: 10.1093/sleep/33.2.225.

Reference Type RESULT
PMID: 20175406 (View on PubMed)

Other Identifiers

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190-904

Identifier Type: -

Identifier Source: org_study_id

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