Histamine H1/H2 Receptors and Training Adaptations

NCT ID: NCT04450134

Last Updated: 2024-06-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

19 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-10-02

Study Completion Date

2021-04-14

Brief Summary

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Exercise training is beneficial for both health and performance. Histamine has been shown to be involved in the acute exercise response. The current study addresses the role of histamine H1/H2 receptor signaling in the chronic training-induced adaptations. Results from this study will yield more insights into the molecular mechanisms of adaptations to exercise training.

Detailed Description

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Conditions

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Exercise Training Physical Activity

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Placebo + exercise vs histamine blockade + exercise
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors
Double-blind for researchers and participants

Study Groups

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Placebo

6 weeks high-intensity interval training + placebo intake

Group Type PLACEBO_COMPARATOR

Lactose

Intervention Type OTHER

Placebo: Lactose capsules

High-intensity interval training (HIIT)

Intervention Type OTHER

6 weeks HIIT

Blockade

6 weeks high-intensity interval training + histamine H1/H2 receptor blockade

Group Type EXPERIMENTAL

Fexofenadine Hydrochloride

Intervention Type DRUG

H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride

Famotidine

Intervention Type DRUG

H2 receptor antagonist: 40 mg Famotidine

High-intensity interval training (HIIT)

Intervention Type OTHER

6 weeks HIIT

Interventions

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Lactose

Placebo: Lactose capsules

Intervention Type OTHER

Fexofenadine Hydrochloride

H1 receptor antagonist: 540 mg Fexofenadine Hydrochloride

Intervention Type DRUG

Famotidine

H2 receptor antagonist: 40 mg Famotidine

Intervention Type DRUG

High-intensity interval training (HIIT)

6 weeks HIIT

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Sedentary or low levels of physical activity
* Caucasian

Exclusion Criteria

* Chronic diseases
* Medication use
* Smoking
* Excessive alcohol consumption
* Seasonal allergies
Minimum Eligible Age

18 Years

Maximum Eligible Age

50 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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Research Foundation Flanders

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role collaborator

University Ghent

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Department of Movement and Sports Sciences, Ghent University

Ghent, Oost-Vlaanderen, Belgium

Site Status

Countries

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Belgium

Other Identifiers

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HIST-TRAINING (BC-06009)

Identifier Type: -

Identifier Source: org_study_id

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