Lipid Metabolism in COVID-19 Severe Pneumonia Compared With Severe Pneumonia Caused by Other Pathogen

NCT ID: NCT04435223

Last Updated: 2026-02-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

62 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-04-07

Study Completion Date

2020-05-07

Brief Summary

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SARS-COV 2 infection might be responsible for sever pneumonia. Obesity seems to be a risk factor for severe SARS-COV 2 pneumonia. Lipid metabolism alteration are described with both obesity and sepsis. The aim of the present study was to describe association between lipid metabolism, obesity, sepsis inflammation and clinical outcome in COVID-19 patient with severe pneumonia compared with severe pneumonia caused by other pathogenes.

Detailed Description

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Conditions

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COVID-19 Severe Pneumonia Severe Pneumonia Due to Other Pathogene

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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COVID-19 severe pneumonia

biological assays in particular on the lipid metabolism

Intervention Type BIOLOGICAL

bioassays carried out on samples already collected and conserved

Severe pneumonia due to other pathogene

biological assays in particular on the lipid metabolism

Intervention Type BIOLOGICAL

bioassays carried out on samples already collected and conserved

Interventions

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biological assays in particular on the lipid metabolism

bioassays carried out on samples already collected and conserved

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* 2 of the following criteria: Cough/ Dyspnea/ Spitting/ Thoracic pain/ Hyperthermia (\>=38 °C) Hypothermia (\< 35°C) AND new radiologic pulmonary infiltrate
* At admission or within 48 hours following hospital admission
* With 2 qSOFA criteria: MAP =\< 100 mmHg, Respiratory Rate \>= 22, Glasgow score \< 15 OR on mechanical ventilation OR under vasopressor
* Age \> 18
* affiliated to social security

Exclusion Criteria

* Pregnancy
* immunodepression
* Pathology known to cause severe lymphopenia
* hospitalisation within 3 month before inclusion AND sepsis
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire Dijon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Chu Dijon Bourgogne

Dijon, , France

Site Status

Countries

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France

References

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Nguyen M, Bourredjem A, Piroth L, Bouhemad B, Jalil A, Pallot G, Le Guern N, Thomas C, Pilot T, Bergas V, Choubley H, Quenot JP, Charles PE, Lagrost L, Deckert V, de Barros JP, Guinot PG, Masson D, Binquet C, Gautier T, Blot M; Lymphonie study group. High plasma concentration of non-esterified polyunsaturated fatty acids is a specific feature of severe COVID-19 pneumonia. Sci Rep. 2021 May 24;11(1):10824. doi: 10.1038/s41598-021-90362-9.

Reference Type RESULT
PMID: 34031519 (View on PubMed)

Other Identifiers

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NGUYEN AOIc 2020

Identifier Type: -

Identifier Source: org_study_id

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