Evaluation of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation Using Conventional Laryngoscope Versus C-MAC Video Laryngoscope in Patients Undergoing Elective Coronary Artery Bypass Grafting (CABG) Surgery

NCT ID: NCT04433884

Last Updated: 2020-06-16

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 86 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-06-07
• Study Completion Date: 2021-01-31

Brief Summary

This study is being done to compare hemodynamic response upon endotracheal intubation using either conventional laryngoscopy with Macintosh blade versus C-Mac video laryngoscope in patients undergoing elective coronary artery bypass grafting without anticipated difficult airway.

Detailed Description

Patients will be premeditated with 7.5mg oral midazolam approximately 45-60 minutes prior to anesthesia. The standard monitoring of Electrocardiography for ST analysis and SPO2 will be monitored continuously. Capnography, tidal volume and airway pressure will also be monitored during anesthesia. Arterial line for invasive Blood Pressure monitoring, wide bore IV cannula will be placed before induction of anesthesia. Anesthesia technique will be standardized in both groups. After pre-oxygenation, anesthesia co-induction will be done with midazolam 0.02-0.05 mg/kg, propofol 0.5-1mg/kg and fentanyl 5mcg/kg. Cis-atracurium 0.15mg/kg will be used as muscle relaxant. Patient will be ventilated manually by using isoflurane (1% end tidal) in oxygen using facemask. ETT will be placed orally via direct laryngoscopy by MC and C-MAC blade 3 or 4 when a Train of Four would not be achieved. All intubation will be performed by senior experienced anesthetist having experience of at least 20 intubations using video laryngoscope.

After induction a central venous catheter will be placed for central venous pressure monitoring and a thermo dilution Swan Ganz catheter will be inserted if indicated.

Tracheal intubation will be performed using the standard Macintosh laryngoscope(MC) or C- MAC video laryngoscope (VL) (Karl Storz, Tuttlingen, Germany).

Hemodynamic changes, laryngoscopic view, the number of attempts, the time required for laryngoscopy and tracheal intubation, changes in rhythm, and intraoperative and post operative complications will be recorded. Heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure (DAP) and mean arterial pressure (MAP) along with peripheral oxygen saturation (SpO2), will be recorded before (T1) and after induction (T2), 1 minute after intubation (T3), 5 min (T4) and 10 min (T5)post intubation. End tidal carbon dioxide (EtCO2) will be recorded immediately after induction (T2), immediately after intubation 1 minute (T3), 5 min (T4) and 10 min (T5) post intubation. Measurements obtained after induction of anesthesia when the hemodynamics will be stable (post induction) will be considered as baseline measurements in the study.

Duration of laryngoscopy (DOL) is defined as the time from oral placement of the laryngoscope blade to obtaining the best glottic view. For the evaluation of glottic view during laryngoscopy, modified Cormack and Lehane Scoring System (m CL) and percentage of the glottis opening (POGO) score will be used. Duration of intubation (DOI) is defined as the time interval between oral placement of the ET to the attainment of tracing of 3 EtCO2 waveforms after intubation and initiation of mechanical ventilation. An attempt is defined as the time from introduction of laryngoscope into the oral cavity until its removal. Three attempts at intubation will be allowed for all groups. Failure to intubate will be defined as the inability to intubate after three attempts. An alternative technique will be used in cases of failure as per the discretion of anesthetist. In the case of multiple attempts, the duration of each attempt will be recorded. The duration of laryngoscopy and intubation (DOLI) is defined as the sum of all intubation attempts. The hemodynamic changes after intubation will be evaluated after successful intubation. After the study period, the anesthetic agents will be used as per the patient requirement. A number of unsuccessful attempts of intubation, complications encountered during intubation (bleeding, lacerations, dental injury, etc.,), and optimal laryngeal external manipulation (OLEM) during intubation will be recorded. The management of these complications will be done by primary anaesthesia team as per their feasibility and the costs of management of these complications will be covered under hospital insurance. Difficult intubation will be assessed by using Intubation Difficulty score (Table 1), Thyromental distance and Upper lip bite test.

Adverse effects of A number unsuccessful attempts of intubation, complications encountered during intubation (bleeding, lacerations, dental injury, etc.,), and optimal laryngeal external manipulation (OLEM) during intubation will be recorded.

Conditions

Intubation Complication

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: PREVENTION
• Blinding Strategy: SINGLE

Study Groups

Conventional MAC Laryngoscope

Patients in this group will undergo intubation using conventional macintosh laryngoscope

Group Type: EXPERIMENTAL

Endotracheal intubation using a laryngoscope

Intervention Type: DEVICE

Patients will undergo intubation using 2 different types of laryngoscopes and their hemodynamic response would be recorded

C-MAC Video laryngoscope

Patients in this group will undergo intubation using video C-Mac laryngoscope

Group Type: EXPERIMENTAL

Endotracheal intubation using a laryngoscope

Intervention Type: DEVICE

Patients will undergo intubation using 2 different types of laryngoscopes and their hemodynamic response would be recorded

Interventions

Endotracheal intubation using a laryngoscope

Patients will undergo intubation using 2 different types of laryngoscopes and their hemodynamic response would be recorded

Intervention Type: DEVICE

Eligibility Criteria

Inclusion Criteria

• Age 35-65
• Elective Coronary Artery By Pass Grafting
• American Society Of Anesthesiologist III/IV
• Unanticipated difficult airway
• Mallampati I-II

Exclusion Criteria

• Obese Body Mass Index > 35kg/m2
• Left Main Coronary Artery critical Disease
• Recent MI or unstable Angina
• Left heart failure/ Left ventricular ejection fraction<35%
• Upper lip bite test class III
• Thyromental distance <6.0 cm
• Emergency surgery
• Anticipated difficult airway
• Respiratory Diseases
• Bleeding diathesis
• Neurological deficit
• Limited nuchal Range of motion
• Gastro Esophageal Reflux Disease

• Minimum Eligible Age: 35 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Aga Khan University

OTHER

Sponsor Role: lead

Responsible Party

Sehrish khan

Resident

Responsibility Role: PRINCIPAL_INVESTIGATOR

Locations

Department of Anesthesiology

Karachi, Sindh, Pakistan

Site Status: RECRUITING

Countries

Pakistan

Central Contacts

Sehrish Khan, MBBS

Role: CONTACT

sehrish.khan@aku.edu

923347126366

Khalid Samad, MBBS,FCPS(Anesthesiology)

Role: CONTACT

khalid.samad@aku.edu

923343311603

Facility Contacts

Khalid Samad, MBBS,FCPS(Anesthesiology)

Role: primary

khalid.samad@aku.edu

923343311603

Other Identifiers

2020-3278-9046

Identifier Type: -

Identifier Source: org_study_id