Effects of Wholegrains on Children's Health (KORN)

NCT ID: NCT04430465

Last Updated: 2021-05-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

55 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-03

Study Completion Date

2021-05-04

Brief Summary

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KORN investigates the effects of wholegrain oat and rye intake on health and cognitive wellbeing in children with overweight.

Detailed Description

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The purpose of KORN is to investigate the effects of wholegrain oat and rye intake on cardiometabolic health in slightly overweight 8-13-year-old children. Moreover, KORN aims to investigate effects on body weight and body composition, inflammatory markers, gastrointestinal wellbeing and cognitive function and explore the potential underlying mechanisms through assessment of changes in the children's gut microbiota as well as potential genotype-dependent and sex-specific effects.

The study has a randomized controlled cross-over design. In two 8-week dietary periods the children will receive grain products (cereals, breads, pasta etc) with either high or low content of wholegrain from oat and rye in random order. Measurements and biological sampling will be performed at 0, 8 and 16 weeks.

Conditions

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Cardiometabolic Health Gastro-intestinal Wellbeing Cognitive Function Overweight

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

PREVENTION

Blinding Strategy

SINGLE

Outcome Assessors
The intervention and data collection will be conducted unmasked. The data set will be masked before data analysis by staff not involved in the study.

Study Groups

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High wholegrain then low wholegrain

Starting with high wholegrain intervention followed by low wholegrain intervention

Group Type EXPERIMENTAL

Grain products high in wholegrains from oat and rye

Intervention Type DIETARY_SUPPLEMENT

A selection of grainproducts high in wholegrain from oat and rye, including cereals, bread, rolls, and pasta is replacing habitual grain products

Grain products low in wholegrains

Intervention Type DIETARY_SUPPLEMENT

A selection of grainproducts low in wholegrain, including cereals, bread, rolls, and pasta is replacing habitual grain products

Low wholegrain then high wholegrain

Starting with low wholegrain intervention followed by high wholegrain intervention

Group Type EXPERIMENTAL

Grain products high in wholegrains from oat and rye

Intervention Type DIETARY_SUPPLEMENT

A selection of grainproducts high in wholegrain from oat and rye, including cereals, bread, rolls, and pasta is replacing habitual grain products

Grain products low in wholegrains

Intervention Type DIETARY_SUPPLEMENT

A selection of grainproducts low in wholegrain, including cereals, bread, rolls, and pasta is replacing habitual grain products

Interventions

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Grain products high in wholegrains from oat and rye

A selection of grainproducts high in wholegrain from oat and rye, including cereals, bread, rolls, and pasta is replacing habitual grain products

Intervention Type DIETARY_SUPPLEMENT

Grain products low in wholegrains

A selection of grainproducts low in wholegrain, including cereals, bread, rolls, and pasta is replacing habitual grain products

Intervention Type DIETARY_SUPPLEMENT

Other Intervention Names

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Wholegrain Refined grain

Eligibility Criteria

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Inclusion Criteria

* Boys and girls 8-13 years of age
* Be overweight i.e. have a parent-reported BMI of at least +1 standard deviation above the median according to the age and sex-standardized Danish growth curves
* Be healthy
* Like grain products and eat them daily
* Speak Danish in order to understand the study procedures
* At least one parent must read and speak Danish, in order to be properly informed about the study procedures
* Parents must have freezer capacity for 2 weeks bread provision

Exclusion Criteria

* Allergy or intolerance to the study foods, including gluten
* Use of dietary fiber supplements (e.g. HUSK) or probiotic supplements
* Dieting or on a special diet
* Serious chronic illnesses and diseases that may interfere with study outcomes
* Use of medication that may affect study outcomes, including use of antibiotics the last month
* Concomitant participation in other studies involving dietary supplements, drugs or blood sampling
* Living in a household with another participating child
Minimum Eligible Age

8 Years

Maximum Eligible Age

13 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Chalmers University of Technology

OTHER

Sponsor Role collaborator

University of Copenhagen

OTHER

Sponsor Role lead

Responsible Party

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Camilla Trab Damsgaard

Associate Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Department of Nutrition, Exercise and Sports, University of Copenhagen

Frederiksberg, , Denmark

Site Status

Countries

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Denmark

References

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Madsen MTB, Landberg R, Nielsen DS, Zhang Y, Anneberg OMR, Lauritzen L, Damsgaard CT. Effects of Wholegrain Compared to Refined Grain Intake on Cardiometabolic Risk Markers, Gut Microbiota, and Gastrointestinal Symptoms in Children: A Randomized Crossover Trial. Am J Clin Nutr. 2024 Jan;119(1):18-28. doi: 10.1016/j.ajcnut.2023.10.025. Epub 2023 Oct 28.

Reference Type DERIVED
PMID: 37898434 (View on PubMed)

Other Identifiers

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D225

Identifier Type: -

Identifier Source: org_study_id

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