The Acute Effects Fortified Nutritional Supplementation on Childhood Cognition
NCT ID: NCT02630667
Last Updated: 2016-12-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
113 participants
INTERVENTIONAL
2012-06-30
Brief Summary
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Detailed Description
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The effects of differentially absorbed carbohydrates on brain and cognition are unknown, especially when ingested via a fortified nutritional beverage providing a balanced array of nutrients. The aim of this study is to investigate the acute, transient effect of nutrient supplementation with varied carbohydrate systems in preadolescent children (i.e., 9-10 years).
Participants will be randomized to receive one of three treatment nutritional formulations containing carbohydrates with varying absorption rates along with a non-caloric placebo. Participants will perform a cognitive battery in the fasted condition, shortly after treatment ingestion, and an hour after ingestion. Group differences in performance will be contrasted to assess the effects of different carbohydrate types on children's cognitive function following an overnight fast.
Findings from this study will inform our understanding of the macronutrient profile of breakfast that may potentially improve children's cognitive performance in the morning.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TRIPLE
Study Groups
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SLOW Carbohydrate
Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response.
SLOW Carbohydrate
Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response
MEDIUM Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response.
MEDIUM Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response
FAST Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response.
FAST Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response
Non-Caloric Placebo
Non-caloric placebo consisting of artificial sweeteners
SLOW Carbohydrate
Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response
MEDIUM Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response
FAST Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response
Interventions
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SLOW Carbohydrate
Treatment consists of a carbohydrate blend designed to elicit a slow postprandial glycemic response
MEDIUM Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a medium/moderate postprandial glycemic response
FAST Carbohydrate
Treatment consists of only one carbohydrate source designed to elicit a fast postprandial glycemic response
Eligibility Criteria
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Inclusion Criteria
* Participants must be between the ages of 9-10 years old at the time of testing age
* Normal or corrected-to-normal vision based on the minimal 20/20 standard in order to complete the cognitive task (below 20/20 vision).
* Participants must have an IQ \> 85 (IQ \< 85).
Exclusion Criteria
* Use of anti-psychotic, anti-depressant, anti-anxiety medication, as well as those medications used for ADD/ADHD (use of any anti-psychotic, anti-depressant, anti-anxiety, and ADD/ADHD medications).
* Early pubertal status, as measured by a modified test of the Tanner Staging System (onset of puberty as determined by Tanner).
* Lactose intolerance
* Allergies to milk and/or soy
* Adherence to a strict vegan diet
9 Years
10 Years
ALL
Yes
Sponsors
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Abbott Nutrition
INDUSTRY
University of Illinois at Urbana-Champaign
OTHER
Responsible Party
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Principal Investigators
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Charles Hillman, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Illinois at Urbana-Champaign
Locations
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Department of Kinesiology and Community Health
Urbana, Illinois, United States
Countries
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References
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Walk AM, Raine LB, Kramer AF, Cohen NJ, Hillman CH, Khan NA. Adiposity is related to neuroelectric indices of motor response preparation in preadolescent children. Int J Psychophysiol. 2020 Jan;147:176-183. doi: 10.1016/j.ijpsycho.2019.10.014. Epub 2019 Nov 19.
Other Identifiers
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12641
Identifier Type: -
Identifier Source: org_study_id