Evaluation of the Tolerance of Ceftaroline and Ceftobiprole in the Management of BJI / PJI

NCT ID: NCT04409769

Last Updated: 2020-06-05

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

22 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-01

Study Completion Date

2020-05-05

Brief Summary

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Staphyloccous aureus and coagulase negative staphylocci are responsible of a large marjority of PJI. Regarding the high rate of methicillin resistance, current guidelines recommend the use of a glycopeptide, and most frequently vancomycin, as the anti-gram positive agent in empirical therapy, while awaiting the microbiological results. Vancomycin is not considered as a safe antibiotic, and daptomycin is frequently an alternative option.

Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. As some data report a synergistic activity with daptomycin, they could be an option in pandrug-resistant staphylococci BJI, but their use if off label in this indication.

Detailed Description

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Conditions

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Bone and Joint Infection Antibiotic Reaction

Study Design

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Observational Model Type

COHORT

Study Time Perspective

RETROSPECTIVE

Study Groups

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Description of use of ceftaroline and ceftobiprole

description of patients and their PJI/BJI,conditions of use, adverse event

Description of use of ceftaroline and ceftobiprole

Intervention Type OTHER

Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. Description of condition of use of thoses antibiotics in PJI and BJI

Interventions

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Description of use of ceftaroline and ceftobiprole

Ceftaroline and ceftobiprole are the only betalactam active on methicillin-resistant staphylococci. Description of condition of use of thoses antibiotics in PJI and BJI

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* patients having had a PJI or BJI treated whith ceftaroline and/or ceftobiprole

Exclusion Criteria

\-
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Hospices Civils de Lyon

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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Hospices Civils de Lyon

Lyon, , France

Site Status

Countries

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France

Related Links

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Other Identifiers

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20-157

Identifier Type: -

Identifier Source: org_study_id

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