Root Canal Treatment Outcome in Patients Under Bisphosphonate Therapy

NCT ID: NCT04399720

Last Updated: 2020-05-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

111 participants

Study Classification

OBSERVATIONAL

Study Start Date

2009-01-07

Study Completion Date

2017-12-15

Brief Summary

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The aim of this study was to evaluate the survival rate and healing time of compromised teeth and seriously compromised teeth that were endodontically treated in patients which received bisphosphonate therapy . Clinical complications, success and survival rate was reported. Mean clinical parameters, clinical symptoms and presence of periapical radilucency were recorded.

Detailed Description

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The study was conducted in one University Endodontic Clinical Department - Dental School between January 2009 and December 2017.

Root canal treatment was performed according previously reported operative protocols.

Conditions

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Root Canal Infection Bisphosphonate-Associated Osteonecrosis Periapical Abscess Endodontically Treated Teeth

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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BPS group

patients under Bisphosphonate therapy for at least 24 months

Root canal treatment

Intervention Type PROCEDURE

Root canal treatment using a standard manual k file instrumentation and carrier-based root canal filling technique

healthy patients

healthy patients not assuming with no previous Bisphosphonate assumption

Root canal treatment

Intervention Type PROCEDURE

Root canal treatment using a standard manual k file instrumentation and carrier-based root canal filling technique

Interventions

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Root canal treatment

Root canal treatment using a standard manual k file instrumentation and carrier-based root canal filling technique

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients affected by endodontic disease and able to attend a hygiene recall program

Exclusion Criteria

* inability to attend a recall hygien program
Minimum Eligible Age

40 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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University of Bologna

OTHER

Sponsor Role lead

Responsible Party

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Fausto Zamparini

DDS,MS,PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

References

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Pirani C, Chersoni S, Montebugnoli L, Prati C. Long-term outcome of non-surgical root canal treatment: a retrospective analysis. Odontology. 2015 May;103(2):185-93. doi: 10.1007/s10266-014-0159-0. Epub 2014 Jun 8.

Reference Type RESULT
PMID: 24908421 (View on PubMed)

Prati C, Pirani C, Zamparini F, Gatto MR, Gandolfi MG. A 20-year historical prospective cohort study of root canal treatments. A Multilevel analysis. Int Endod J. 2018 Sep;51(9):955-968. doi: 10.1111/iej.12908. Epub 2018 Mar 7.

Reference Type RESULT
PMID: 29432651 (View on PubMed)

Other Identifiers

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bifosfonendo

Identifier Type: -

Identifier Source: org_study_id

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