Treatment of Angiotensin Peptide (1-7) for COVID-19

NCT ID: NCT04375124

Last Updated: 2022-04-01

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

9 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-25

Study Completion Date

2020-09-30

Brief Summary

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Novel Coronavirus is reported to cause COVID-19, recently. It's known that this virus uses ACE (angiotensin converting enzyme) 2 receptors to enter human cells and also blocks the activity of ACE 2. Upon these data the investigators hypothesize that, mortal hyper-inflammation state which is shown in COVID-19 cases, can be a result of angiotensin peptide (1-7) deficiency. Therefore, the aim of this study is to evaluate the possible effect of angiotensin peptide (1-7) supplementation on treatment of COVID-19 cases.

Detailed Description

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Novel Coronavirus is reported to cause COVID-19, recently. It's known that this virus uses ACE (angiotensin converting enzyme) 2 receptors to enter human cells and also blocks the activity of ACE 2. Upon these data the investigators hypothesize that, mortal hyper-inflammation state which is shown in COVID-19 cases, can be a result of angiotensin peptide (1-7) deficiency. Therefore, the aim of this study is to evaluate the possible effect of plasma derived angiotensin peptide (1-7) supplementation on treatment of COVID-19 cases.

Conditions

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COVID-19

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

This group will receive angiotensin peptide (1-7) during their treatment at hospital.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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non-peptide group

This group will receive routine treatment and care for COVID-19.

Group Type NO_INTERVENTION

No interventions assigned to this group

peptide group

This group will receive angiotensin peptide (1-7) supplementation in addition to routine treatment and care for COVID-19.

Group Type ACTIVE_COMPARATOR

Biological/Vaccine: Angiotensin peptide (1-7) derived plasma

Intervention Type BIOLOGICAL

angiotensin peptide (1-7) derived plasma will be given to COVID-19 positive participants

Interventions

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Biological/Vaccine: Angiotensin peptide (1-7) derived plasma

angiotensin peptide (1-7) derived plasma will be given to COVID-19 positive participants

Intervention Type BIOLOGICAL

Eligibility Criteria

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Inclusion Criteria

* accepted to participate with an informed consent
* proven positive COVID-19

Exclusion Criteria

* declined to participate
* genetic/chromosomal abnormalities
* any kind of history of previous adverse events with transfusion
* diagnosis of immune deficiency
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Kanuni Sultan Suleyman Training and Research Hospital

OTHER

Sponsor Role lead

Responsible Party

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Hasan Onal

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Kanuni Sultan Suleyman Training and Research Hospital

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

Other Identifiers

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KSSEAH--0059

Identifier Type: -

Identifier Source: org_study_id

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