Rapid Versus Prolonged Inpatient Up-Titration of Captopril
NCT ID: NCT00742040
Last Updated: 2008-08-27
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE2
50 participants
INTERVENTIONAL
2008-08-31
2009-12-31
Brief Summary
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Detailed Description
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The ultimate goal of this study is to be in a position to provide physicians caring for children with heart disease information about how to safely up-titrate this widely used medication, and by doing so to improve dosing in the wider pediatric population.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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1
Captopril
A rapid 3-day up-titration protocol
2
Captopril
A slower 9-day up-titration protocol
Interventions
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Captopril
A rapid 3-day up-titration protocol
Captopril
A slower 9-day up-titration protocol
Eligibility Criteria
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Inclusion Criteria
* Primary physician has decided to commence ACEi (the division has agreed that our institutional choice will be to start patients on captopril and up-titrate to optimal dose before converting to other ACEi)
* Patients who have been initiated on captopril within the prior 24 hours, but have not yet started up-titration, will be eligible to be randomized
Exclusion Criteria
* Infants on the neonatal intensive care unit
* Treatment with any ACEi for more than 24 hours within the preceding 6 months
* Age \> 18 years
18 Years
ALL
No
Sponsors
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The Hospital for Sick Children
OTHER
Responsible Party
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The Hospital for Sick Children
Principal Investigators
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Paul Kantor, MD
Role: PRINCIPAL_INVESTIGATOR
The Hospital for Sick Children
Locations
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The Hospital for Sick Children
Toronto, Ontario, Canada
Countries
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Facility Contacts
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Paul Kantor, MD
Role: primary
References
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Roche SL, Timberlake K, Manlhiot C, Balasingam M, Wilson J, George K, McCrindle BW, Kantor PF. Angiotensin-Converting Enzyme Inhibitor Initiation and Dose Uptitration in Children With Cardiovascular Disease: A Retrospective Review of Standard Clinical Practice and a Prospective Randomized Clinical Trial. J Am Heart Assoc. 2016 May 20;5(5):e003230. doi: 10.1161/JAHA.116.003230.
Other Identifiers
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1000012229
Identifier Type: -
Identifier Source: org_study_id